Results 41 to 50 of about 14,419 (248)

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

BadiRate: estimating family turnover rates by likelihood-based methods [PDF]

, 2014
Podeu consultar el programari a: http://hdl.handle.net/2445/53403Motivation: The comparative analysis of gene gain and loss rates is critical for understanding the role of natural selection and adaptation in shaping gene family sizes. Studying complete
Cohen, Csuros, Csuros, De Bie, F. G. Vieira, Hahn, Hahn, J. Rozas, Johnson, Liu, Nei, Nozawa, Ohno, P. Librado, Sanchez-Gracia, Vieira   +15 more
core   +2 more sources

Quantifying the accuracy of ancestral state prediction in a phylogenetic tree under maximum parsimony [PDF]

Journal of Mathematical Biology, 2018
In phylogenetic studies, biologists often wish to estimate the ancestral discrete character state at an interior vertex v of an evolutionary tree T from the states that are observed at the leaves of the tree.
Lina Herbst, Heyang Li, M. Steel
semanticscholar   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Improved gene tree error correction in the presence of horizontal gene transfer [PDF]

, 2014
Motivation: The accurate inference of gene trees is a necessary step in many evolutionary studies. Although the problem of accurate gene tree inference has received considerable attention, most existing methods are only applicable to gene families ...
Bansal, Bapteste, Burleigh, Chen, Choi, David, Delsuc, Doyon, Durand, Eric J. Alm, Felsenstein, Goodman, Guindon, Górecki, Hallett, Harding, Koonin, Lerat, Lerat, Li, Libeskind-Hadas, Liu, Ma, Manolis Kellis, Mukul S. Bansal, Nguyen, Organ, Ovadia, Page, Rambaut, Rasmussen, Rutschmann, Saitou, Salter, Sanderson, Sennblad, Shimodaira, Stamatakis, Stolzer, Storm, Thornton, Tofigh, Tofigh, Vilella, Wapinski, Whelan, Wu, Yang, Yi-Chieh Wu, Yule, Zhaxybayeva, Zhaxybayeva, Åkerborg   +52 more
core   +2 more sources

Ancestral Sequence Reconstruction with Maximum Parsimony [PDF]

Bulletin of Mathematical Biology, 2017
One of the main aims in phylogenetics is the estimation of ancestral sequences based on present-day data like, for instance, DNA alignments. One way to estimate the data of the last common ancestor of a given set of species is to first reconstruct a ...
Lina Herbst, Mareike Fischer
semanticscholar   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

Marinomonas brasilensis sp. nov., isolated from the coral Mussismilia hispida, and reclassification of Marinomonas basaltis as a later heterotypic synonym of Marinomonas communis [PDF]

, 2011
A Gram-negative, aerobic bacterium, designated strain R-40503(T), was isolated from mucus of the reef-builder coral Mussismilia hispida, located in the Sao Sebastiao Channel, Sao Paulo, Brazil.
Alves, Anne Willems, Baumann, Eck, Fabiano L. Thompson, Goris, Ilse Cleenwerck, Luciane A. Chimetto, Marcelo Brocchi, Paul De Vos, Saitou, Savelkoul, Stackebrandt, van Landschoot, Willems   +14 more
core   +2 more sources

Ancient whole genome duplications and the evolution of the gene duplication and loss rate

bioRxiv, 2019
Gene tree - species tree reconciliation methods have been employed for studying ancient whole genome duplication (WGD) events across the eukaryotic tree of life.
A. Zwaenepoel, Y. Van de Peer
semanticscholar   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source