Results 81 to 90 of about 6,406,771 (368)

Gradient Maximum Principle for Minima [PDF]

Journal of Optimization Theory and Applications, 2002
The authors show that the maximum of any component of the gradient of a minimum of the integral functional \[ I(u) =\int_\Omega [f(Du) + g(u)] dx \] must occur on the boundary of the domain \(\Omega\) provided the functional \(I\) is strictly convex. No further regularity (or growth) conditions are assumed. Such results are well known (see, for example,
MARICONDA, CARLO, TREU, GIULIA
openaire   +2 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

The Maximum Principle for Optimal Control Problems with Time Delays

SIAM Journal of Control and Optimization, 2017
: In this paper we present necessary conditions for optimal control problems with time delays. The dynamic constraint is formulated as a control delay differential equation, with time delays occuring in both state and control variables.
Andrea Boccia, R. Vinter
semanticscholar   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

A Clustering Method Based on the Maximum Entropy Principle

Entropy, 2015
Clustering is an unsupervised process to determine which unlabeled objects in a set share interesting properties. The objects are grouped into k subsets (clusters) whose elements optimize a proximity measure.
Edwin Aldana-Bobadilla, Angel Kuri-Morales   +1 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

A principle of maximum ignorance for semiclassical gravity

Journal of High Energy Physics
The principle of maximum ignorance posits that the coarse-grained description of a system is maximally agnostic about its underlying microscopic structure.
Jan de Boer, Diego Liska, Boris Post, Martin Sasieta   +3 more
doaj   +1 more source

Maximum principle and the fourth order boundary value problem

Mathematical Modelling and Analysis, 2011
This paper is devoted to the study the nonlinear boundary value problem . We state a maximum principle related with the operator  and apply it to prove the existence and approximation of solutions to the problem (i), (ii), in presence of properly ordered
Inara Yermachenko
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source