Results 91 to 100 of about 4,724 (240)

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 673-684, October 2024.
Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing. The use of animal models confronts hurdles related to ethical considerations and the successful translation of findings from animals to humans.
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani   +3 more
wiley   +1 more source

Genomic and phenotypic characterization of the Oropouche virus strain implicated in the 2022–24 large‐scale outbreak in Brazil

Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Abstract The Orthobunyavirus oropoucheense species encompasses a group of arthropod‐borne zoonotic viruses transmitted by biting midges to animals including humans. Several large‐scale human outbreaks caused by the prototype member of this species, Oropouche virus (OROV) have been documented since the 1970s and were primarily confined to the Amazon ...
Elisa de A. N. Azevedo, Alexandre F. da Silva, Verônica G. da Silva, Lais C. Machado, Gustavo B. de Lima, Bruno I. M. Ishigami, Keilla M. Paz e Silva, Mayara M. de O. M. da Costa, Diego A. Falcão, Andreza P. Vasconcelos, Clintiano C. da Silva, Felipe G. Naveca, Matheus F. Bezerra, Tulio de L. Campos, Bartolomeu Acioli‐Santos, Marcelo H. S. Paiva, Clarice N. L. de Morais, Gabriel L. Wallau   +17 more
wiley   +1 more source

Mayaro virus fever: a necessary alert

Revista Habanera de Ciencias Médicas, 2016
Miguel Angel Serra Valdes
doaj   +1 more source

Alpha‐mannosidase‐2 modulates arbovirus infection in a pathogen‐ and Wolbachia‐specific manner in Aedes aegypti mosquitoes

Insect Molecular Biology, Volume 33, Issue 4, Page 362-371, August 2024.
Mosquito genetic background can modulate Wolbachia pathogen‐blocking phenotypes. The alpha‐mannosidase‐2 gene has previously been identified as a potential candidate. αMan2 CRISPR KO mutagenesis suppresses dengue virus titres but increases Mayaro virus titres, in Wolbachia‐uninfected mosquitoes.
Nadya Urakova, Renuka E. Joseph, Allyn Huntsinger, Vanessa M. Macias, Matthew J. Jones, Leah T. Sigle, Ming Li, Omar S. Akbari, Zhiyong Xi, Konstantinos Lymperopoulos, Richard T. Sayre, Elizabeth A. McGraw, Jason L. Rasgon   +12 more
wiley   +1 more source

Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle [PDF]

, 2017
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described.
A Macdonald, A Stankiewicz-Drogoń, AB Cecilio, ACG Jardim, Adélia Cristina Oliveira Cintra, AJ Thompson, Ana Carolina Gomes Jardim, BL Pearlman, C Bon, C Bon, C Sarrazin, C-I Popescu, Carina Machado Pereira, Carsten Zothner, Cintia Bittar, D Fenard, DL Wyles, DL Wyles, E Sugawara, EA Dennis, F Xiao, G Barba, G Faure, G Faure, G Faure, G Wandeler, GH Syed, Guilherme Rodrigues Fernandes Campos, H Breithaupt, H Jin, I-W Park, J Blaising, J Goldwasser, Jacqueline Farinha Shimizu, Jason Blackard, K. H. Slotta, KF Santos, KJ Blight, KJ Helbig, L Zona, M Houghton, M Krawczyk, Mariana Nogueira Batista, Mark Harris, ME Burlone, MJ Sofia, N Calland, N Dabbouseh, P Bailey, P Gastaminza, P Meuleman, Paula Rahal, R a Hendon, R Bartenschlager, R Kini, R Meenakshisundaram, R Talwani, R Yan, S Ciesek, S Sampaio, S Zhang, SD Aird, SH FERREIRA, Suely da Silva, Suely Vilela Sampaio, T Masaki, T Mosmann, T Wakita, VD Menjon Muller, VD Muller, VDM Muller, Victor Hugo Aquino, VL Petricevich, WS Ayoub, Y Miyanari, Y Nahmias, Á Rojas   +76 more
core   +8 more sources

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

mSphere, 2018
Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith, Christine L. Pugh, Emily D. Cisney, Sarah L. Keasey, Carolina Guevara, Julia S. Ampuero, Guillermo Comach, Doris Gomez, Margarita Ochoa-Diaz, Robert D. Hontz, Robert G. Ulrich   +10 more
doaj   +1 more source

Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito‐borne viruses

Insect Science, Volume 31, Issue 3, Page 663-673, June 2024.
Mosquito salivary proteins (MSPs) bear multitudinous functions, embracing facilitating blood feeding and affecting the infection of mosquito‐borne viruses (MBVs) via directly interplaying with MBVs or tuning the homeostasis of host cells. In vivo, MSPs can modulate host's innate and adaptive immunity, which in turn impacts the native infection at the ...
Zhao‐Yang Wang, Kai‐Xiao Nie, Ji‐Chen Niu, Gong Cheng   +3 more
wiley   +1 more source

Structural Relationships to Efficacy for Prazole‐Derived Antivirals

Advanced Science, Volume 11, Issue 18, May 15, 2024.
Characterization of a family of covalent prazole derivative adducts with the Tsg101 UEV domain finds roles for bulk and flexibility in antiviral efficacy and cytotoxicity, while opening avenues for further development of prazole‐based antiviral therapeutics that target Tsg101.
David A. Nyenhuis, Susan Watanabe, Rebecca Bernstein, Rolf E. Swenson, Natarajan Raju, Venkata R. Sabbasani, Chandrasekhar Mushti, Duck‐Yeon Lee, Carol Carter, Nico Tjandra   +9 more
wiley   +1 more source

Studies on the replication of Mayaro virus grown in interferon treated cells

Memorias do Instituto Oswaldo Cruz, 1994
Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells.
M. C. S. Rebello, M. E. F. Fonseca, J. O. Marinho, M. A. Rebello   +3 more
doaj   +1 more source

Integration of Planova filters in manufacturing processes of biologicals improve the virus safety effectively: A review of publicly available data

Biotechnology Progress, Volume 40, Issue 1, January/February 2024.
Abstract The capacity to remove viruses by Planova filters produced by Asahi Kasei, primarily by small virus‐retentive filters, were compiled from data in peer‐reviewed publications and, partly, publicly available data from presentations at conferences (Planova workshops).
Albrecht Gröner
wiley   +1 more source