Results 191 to 200 of about 16,448 (221)

MC1R CpG island regulates MC1R expression and is methylated in a subset of melanoma tumours

Pigment Cell & Melanoma Research, 2018
AbstractMelanocortin 1 receptor (MC1R) is a G protein‐coupled receptor expressed in melanocytes where it plays an important role in skin pigmentation and in the UV response, and has implications in melanoma development. Here we show that methylation of a CpG island (CGI) within the MC1R gene can control expression of MC1R in melanoma. This CGI overlaps
Timothy Budden, Nikola A. Bowden
openaire   +2 more sources

MC1R and the response of melanocytes to ultraviolet radiation [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the
Ana Luisa Kadekaro, Zalfa A Abdel-Malek
exaly   +3 more sources

mc1rPathway Regulation of Zebrafish Melanosome Dispersion

Zebrafish, 2008
Zebrafish rapidly alter their pigmentation in response to environmental changes. For black melanocytes, this change is due to aggregation or dispersion of melanin in the cell. Dispersion and aggregation are controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, which increase upon stimulation by alpha melanocyte-stimulating hormone ...
Jennifer, Richardson, Pia Rengtved, Lundegaard, Natalie L, Reynolds, Julia R, Dorin, David J, Porteous, Ian J, Jackson, E Elizabeth, Patton   +6 more
openaire   +2 more sources

Melanocortin-1 receptor (MC1R): a review for dermatologists

Italian Journal of Dermatology and Venereology
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin.
Guida S., Puig S., Di Resta C., Sallustio F., Mangano E., Stabile G., Longo C., Pellacani G., Guida G., Rongioletti F.   +9 more
openaire   +5 more sources

[MC1R polymorphisms and facial photoaging].

Annales de dermatologie et de venereologie, 2011
The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.The study population comprised 530 French middle-aged women between 44 and 70 years. A trained dermatologist graded the severity of facial skin photoaging from photographs using Larnier's global scale ...
J, Latreille, K, Ezzedine, A, Elfakir, L, Ambroisine, R, Jdid, P, Galan, S, Hercberg, F, Gruber, D, Malvy, E, Tschachler, C, Guinot   +10 more
openaire   +1 more source

The role of MC1R gene in buffalo coat color

Science China Life Sciences, 2010
Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou ...
YongWang, Miao, GuiSheng, Wu, Lei, Wang, DaLin, Li, ShouKun, Tang, JianPing, Liang, HuaMing, Mao, HuaiRong, Luo, YaPing, Zhang   +8 more
openaire   +2 more sources

Polymorphismes du MC1R et photovieillissement du visage

Annales de Dermatologie et de Vénéréologie, 2011
Resume Introduction L’objectif de cette etude etait d’evaluer l’impact du polymorphisme du gene du recepteur de la melanocortine-1 (MC1R) sur la severite du photovieillissement du visage. Methodes Cinq cent trente femmes residant en ile-de-France, âgees de 44 a 70 ans, ont participe a l’etude.
J. Latreille, K. Ezzedine, A. Elfakir, L. Ambroisine, R. Jdid, P. Galan, S. Hercberg, F. Gruber, D. Malvy, E. Tschachler, C. Guinot   +10 more
openaire   +1 more source

Is MC1R involved in swine melanoma : analysis of MC1R alleles in MeLiM families?

2004
International ...
Créchet, Francoise, Du, Zhi Qiang, Vincent-Naulleau, Silvia, Arnaudeau-Begard, C., Le Roy, Pascale, Frelat, G., Geffrotin, Claudine   +6 more
openaire   +2 more sources

MC1R variant alleles and malignant melanoma risk in Israel

European Journal of Cancer, 2009
To evaluate the contribution of MC1R variants to malignant melanoma risk in Israeli Jews, sequencing of the MC1R gene was performed in 132 melanoma patients and 184 ethnically matched controls. Overall, 22 MC1R variants were detected, two were novel (M73I and 496_497insG).
Gilli, Galore-Haskel, Esther, Azizi, Hamida, Mohamdi, Alon, Scope, Valérie, Chaudru, Yael, Laitman, Frida, Barak, Felix, Pavlotsky, Florence, Demenais, Eitan, Friedman   +9 more
openaire   +2 more sources

Asip and MC1R cDNA polymorphism in alpaca

2011
Agouti signaling protein (Asip) and melanocortin 1 receptor (MC1R) represent key players in coat color determination in mammals. To investigate the role of those genes in coat color variation in alpaca, mRNA purified from skin biopsies of different colored animals were reverse-transcribed into single-stranded cDNAs and the coding sequences (CDS ...
C. Bathrachalam, V. La Manna, RENIERI, Carlo, LA TERZA, Antonietta   +3 more
openaire   +1 more source