Results 181 to 190 of about 16,448 (221)

Az α-melanocita stimuláló hormon gyulladáscsökkentő hatása biológiai gátrendszerek tenyészetes modelljein [PDF]

, 2018
Harazin András
core  

Dynamic changes in genes and metabolites during embryonic development of Jiangshan black-bone chickens. [PDF]

Poult Sci
Niu Y, Qiu Z, Zhou Y, Li S, Wu Y, Zhao A, Wang Z.   +6 more
europepmc   +1 more source

Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway. [PDF]

Sci Rep
Zhang J, Liu S, Guo W, Huang Y, Li N.
europepmc   +1 more source

<i>MC1R</i> and <i>IRF4</i> Gene Variants Are Associated with p16INK4a-Positive Epidermal Cells. [PDF]

JID Innov
Murdoch JV, Noordam R, Slagboom PE, van Heemst D, Gunn DA.   +4 more
europepmc   +1 more source

Palmitoylation-dependent activation of MC1R prevents melanomagenesis [PDF]

Nature, 2017
The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and enhances DNA repair after ultraviolet irradiation.
Shuyang Chen, Chengqian Yin, Chunying Li
exaly   +6 more sources

Evidence for Variable Selective Pressures at MC1R [PDF]

American Journal of Human Genetics, 2000
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation. Here we investigate MC1R polymorphism in several populations, for evidence of selection. We conclude that
Eugene Healy, Antti Sajantila, Ian J Jackson   +2 more
exaly   +5 more sources

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]

Nature Communications, 2019
AbstractSome genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether increasing MC1R palmitoylation represents a ...
Shuyang Chen, Xiao Miao, Chengqian Yin
exaly   +5 more sources

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Red hair is the null phenotype of MC1R

Human Mutation, 2008
The Melanocortin-1 Receptor (MC1R) is a G-protein coupled receptor, which is responsible for production of the darker eumelanin pigment and the tanning response. The MC1R gene has many polymorphisms, some of which have been linked to variation in pigmentation phenotypes within human populations.
Kimberley A Beaumont, Richard A Sturm, David L Duffy   +2 more
exaly   +4 more sources