Results 181 to 190 of about 11,568 (220)

MC1R and the response of melanocytes to ultraviolet radiation [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the
François Rouzaud, Ana Luisa Kadekaro, Zalfa A Abdel-Malek   +2 more
exaly   +3 more sources

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MC1R CpG island regulates MC1R expression and is methylated in a subset of melanoma tumours

Pigment Cell & Melanoma Research, 2018
AbstractMelanocortin 1 receptor (MC1R) is a G protein‐coupled receptor expressed in melanocytes where it plays an important role in skin pigmentation and in the UV response, and has implications in melanoma development. Here we show that methylation of a CpG island (CGI) within the MC1R gene can control expression of MC1R in melanoma. This CGI overlaps
Timothy Budden, Nikola A. Bowden
openaire   +2 more sources

The role of MC1R gene in buffalo coat color

Science China Life Sciences, 2010
Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou ...
YongWang, Miao, GuiSheng, Wu, Lei, Wang, DaLin, Li, ShouKun, Tang, JianPing, Liang, HuaMing, Mao, HuaiRong, Luo, YaPing, Zhang   +8 more
openaire   +2 more sources

Novel MC1R variants in Ligurian melanoma patients and controls

Human Mutation, 2004
Several variant forms of the melanocortin-1 receptor gene (MC1R) have been associated with red hair, fair skin and an increased risk for melanoma. Their involvement in melanoma susceptibility is apparently linked both to skin sensitivity and to non-pigmentary pathways. We investigated the frequency of the MC1R variants in the Italian region of Liguria,
Lorenza, Pastorino, Roberto, Cusano, William, Bruno, Francesca, Lantieri, Paola, Origone, Monica, Barile, Sara, Gliori, Graeme A, Shepherd, Richard A, Sturm, Giovanna, Bianchi-Scarra, Giovanna Bianchi, Scarra   +10 more
openaire   +6 more sources

[MC1R polymorphisms and facial photoaging].

Annales de dermatologie et de venereologie, 2011
The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.The study population comprised 530 French middle-aged women between 44 and 70 years. A trained dermatologist graded the severity of facial skin photoaging from photographs using Larnier's global scale ...
J, Latreille, K, Ezzedine, A, Elfakir, L, Ambroisine, R, Jdid, P, Galan, S, Hercberg, F, Gruber, D, Malvy, E, Tschachler, C, Guinot   +10 more
openaire   +1 more source

ADAPTIVE REPTILE COLOR VARIATION AND THE EVOLUTION OF THE MC1R GENE

Evolution, 2004
The wealth of information on the genetics of pigmentation and the clear fitness consequences of many pigmentation phenotypes provide an opportunity to study the molecular basis of an ecologically important trait. The melanocortin-1 receptor (Mc1r) is responsible for intraspecific color variation in mammals and birds.
Rosenblum, Erica Bree, Hoekstra, Hopi, Nachman, Michael W.   +2 more
openaire   +4 more sources

Is MC1R involved in swine melanoma : analysis of MC1R alleles in MeLiM families?

2004
International ...
Créchet, Francoise, Du, Zhi Qiang, Vincent-Naulleau, Silvia, Arnaudeau-Begard, C., Le Roy, Pascale, Frelat, G., Geffrotin, Claudine   +6 more
openaire   +2 more sources

Sequence variation in the Mc1r gene for a group of polymorphic snakes

Gene, 2013
Studying the genetic factors underlying phenotypic traits can provide insight into dynamics of selection and molecular basis of adaptation, but this goal can be difficult for non-model organisms without extensive genomic resources. However, sequencing candidate genes for the trait of interest can facilitate the study of evolutionary genetics in natural
Christian L, Cox, Alison R Davis, Rabosky, Paul T, Chippindale   +2 more
openaire   +2 more sources

Skin colour and skin cancer –MC1R, the genetic link

Melanoma Research, 2002
Pigmentary traits such as red hair, fair skin, lack of tanning ability and propensity to freckle (the RHC phenotype) have been identified as genetic risk factors for both melanoma and non-melanocytic skin cancers when combined with the environmental risk factor of high ultraviolet light exposure.
openaire   +5 more sources

Asip and MC1R cDNA polymorphism in alpaca

2011
Agouti signaling protein (Asip) and melanocortin 1 receptor (MC1R) represent key players in coat color determination in mammals. To investigate the role of those genes in coat color variation in alpaca, mRNA purified from skin biopsies of different colored animals were reverse-transcribed into single-stranded cDNAs and the coding sequences (CDS ...
C. Bathrachalam, V. La Manna, RENIERI, Carlo, LA TERZA, Antonietta   +3 more
openaire   +1 more source