Results 91 to 100 of about 12,611 (227)

Germline MC1R status influences somatic mutation burden in melanoma [PDF]

, 2016
The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene.
A Ozola, A Yates, C Wilks, CM Olsen, D Mitra, DL Duffy, DT Bishop, E Healy, E Hodis, E Pasquali, ED Pleasance, H Ikehata, I Adzhubei, J Cao, JA Newton-Bishop, JC García-Borrón, JE Hauser, JJ Latimer, JR Davies, JS Más, K Cibulskis, K Jagirdar, KA Beaumont, KA Beaumont, L Denat, LB Alexandrov, M Krauthammer, M Krauthammer, MF Berger, P Shriber, P Valverde, PB Cassidy, PC Ng, PF Williams, RA Sturm, S Raimondi, S van Buuren, SA Forbes, SG Jarrett, SG Jarrett, T Dwyer, TH Nasti, V Swope, YW Teh, Z Zhang, ZA Abdel-Malek   +45 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman   +206 more
wiley   +1 more source

Anti‐melanogenic effects of Medicago sativa seed extracts on melanocytes

International Journal of Cosmetic Science, Volume 47, Issue 6, Page 1005-1016, December 2025.
Our study demonstrated that two types of alfalfa seed extract: alfalfa ethanol precipitate (AEP) and alfalfa ethanol supernatant (AES) inhibited melanogenesis through the downregulation of tyrosinase expression, following the inactivation of CREB, b‐catenin and ERK signalling pathway in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16F10 mouse ...
Chae Rin Kim, Jung Woo, Kyu Lim Kim, Minah Choi, Hee Jung Shin, Junoh Kim, Kyung Min Lim, Chang‐Seok Lee   +7 more
wiley   +1 more source

Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

PLoS ONE, 2010
BackgroundResponse to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled
Ada Delaney, Margaret Keighren, Susan M Fleetwood-Walker, Ian J Jackson   +3 more
doaj   +1 more source

Hierarchical modeling of melanocortin 1 receptor variants with skin cancer risk [PDF]

, 2018
The human MC1R gene is highly polymorphic among lightly pigmented populations, and several variants in the MC1R gene have been associated with increased risk of both melanoma and nonmelanoma skin cancers. The functional consequences of MC1R gene variants
Han, Jiali, Joshi, Amit D., Kraft, Peter, Li, Xin   +3 more
core   +1 more source

The Alpaca Melanocortin 1 Receptor: Gene Mutations, Transcripts, and Relative Levels of Expression in Ventral Skin Biopsies

The Scientific World Journal, 2015
The objectives of the present study were to characterize the MC1R gene, its transcripts and the single nucleotide polymorphisms (SNPs) associated with coat color in alpaca. Full length cDNA amplification revealed the presence of two transcripts, named as
Bathrachalam Chandramohan, Carlo Renieri, Vincenzo La Manna, Antonietta La Terza   +3 more
doaj   +1 more source

Evolution of the melanocortin-1 receptor gene (MC1R) in chamois (Rupicapra spp.)

Molecular Phylogenetics and Evolution, 2013
The taxonomy of chamois and the effects of historical and evolutionary events on its diversification are still under discussion given that different morphological and genetic features presented partially discordant views. One of the morphological features that differentiate the two currently considered species, Rupicapra pyrenaica (southern chamois ...
Pérez Méndez, María Trinidad, Essler, Sabine E., Palacios Alberti, Borja, Albornoz Álvarez, Jesús de, Domínguez Sanjurjo, Ana María   +4 more
openaire   +3 more sources

A Genomic Exploration of the Possible De‐Extirpation of the Zanzibar Leopard

Molecular Ecology, Volume 34, Issue 23, December 2025.
ABSTRACT The recently extirpated Zanzibar leopard was the only known African leopard (Panthera pardus spp.) population restricted exclusively to a major island habitat. Although its demise was driven through habitat change and conflict with humans, given its role as a keystone species for the Zanzibar Archipelago, its successful potential ...
Xin Sun, Emily Louisa Cavill, Ashot Margaryan, Jianqing Lin, Søren Thingaard, Tamrini A. Said, Shyam Gopalakrishnan, M. Thomas P. Gilbert   +7 more
wiley   +1 more source

Identifying the Degree of Gene Reuse During Repeated Adaptation

Molecular Ecology, Volume 34, Issue 24, December 2025.
ABSTRACT The degree or extent of gene reuse during repeated adaptation offers key insights into the genomic constraints on evolution. Although many studies have identified signs of genomic repeatability, a thorough synthesis of methods for detecting gene reuse and estimating its extent is missing. In this review, we first propose a simple framework for
Samridhi Chaturvedi, Lakshmi Vineesha Digumarthi, Garima Setia   +2 more
wiley   +1 more source

Histologic and phenotypic factors and MC1R status associated with BRAF(V600E), BRAF(V600K), and NRAS mutations in a community-based sample of 414 cutaneous melanomas [PDF]

, 2016
Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes.
Green, Adele C., Hacker, Elke, Hayward, Nicholas K., Kvaskoff, Marina, Mortimore, Rohan, Olsen, Catherine M., Pandeya, Nirmala, Triscott, Joe, Whiteman, David C., Williamson, Richard M., Wood, Dominic, Yeo, Abrey   +11 more
core   +2 more sources