Results 101 to 110 of about 12,611 (227)

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

Pediatric Anesthesia, Volume 35, Issue 12, Page 1053-1062, December 2025.
ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Maddlie Bardol, Yucheng Sheng, Manuel Baarslag, Adriana Ceci, Frank Dörje, Mari‐Liis Ilmoja, Peter Larsson, Per‐Arne Lönnqvist, Tuuli Methsvat, Pavla Pokorna, Wolfgang Rascher, Joost van Rosmalen, Michael Schroth, Alessandra Simonetti, Dick Tibboel, Irmgard Toni, Catherine Tuleu, Thomas M. K. Völkl, Brian J. Anderson, Stefan Wimmer, Joseph F. Standing, Antje Neubert, CloSed Consortium   +22 more
wiley   +1 more source

Polymorphism and Tissue Expression Analysis of TYR and MC1R Genes in Guinea Pigs with Different Coat-Color Phenotypes

Shiyan dongwu yu bijiao yixue
Objective To explore the polymorphism of tyrosinase (TYR) and melanocortin 1 receptor (MC1R) genes and their mRNA expression levels in relation to coat-color phenotypes in guinea pigs, providing genetic markers for locating dominant traits in guinea pigs.
TANG Yingen, FENG Yaxian, ZHONG Min, WEI Zhen, WANG Lie, LIU Diwen   +5 more
doaj   +1 more source

Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. [PDF]

, 2014
Coat colours and patterns are highly variable in cats and are determined mainly by several genes with Mendelian inheritance. A 2-bp deletion in agouti signalling protein (ASIP) is associated with melanism in domestic cats. Bengal cats are hybrids between
Davis, BW, Gershony, LC, Helps, CR, Lyons, LA, Murphy, WJ, Penedo, MCT   +5 more
core   +1 more source

Unmasking the Desert Phantom: Genetic Evidence Does Not Support the Validity of the Enigmatic Boehme's Horned Viper

Zoologica Scripta, Volume 54, Issue 6, Page 817-822, November 2025.
ABSTRACT The viperid genus Cerastes contains four desert‐adapted species distributed throughout the Saharo‐Arabian arid belt that are typically associated with loose sands. Cerastes boehmei is restricted to one locality in Tunisia and is known only from the holotype.
Vojtěch Waldhauser, Theo Busschau, Gabriel Mochales‐Riaño, Sebastian Scholz, Fernando Martínez‐Freiría, Stephane Boissinot, Salvador Carranza, Andreas Schmitz, Jiří Šmíd   +8 more
wiley   +1 more source

MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair

BMC Medical Genetics, 2012
Background Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R,
Pellegrini Cristina, Fargnoli Maria, Suppa Mariano, Peris Ketty   +3 more
doaj   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle, Agarwal, Agrawal, Aladin, Anderson, Andersson, Annunen, Arnold, Ashford, Atkinson, Bandell, Battie, Battie, Bautista, Bejaoui, Berthele, Beyer, Blau, Bond, Brown, Brown, Brown, Campa, Caraco, Carbonell Sala, Carragee, Cascorbi, Cho, Chou, Chou, Cipollone, Collart, Cox, Dalen, Daly, Dawkins, Dayer, Dayer, Diatchenko, Diatchenko, Diatchenko, Dick, Doehring, Eckhardt, Einarsdottir, Fillingim, Foulkes, Fu, Gasche, Goldberg, Grant, Gross, Gursoy, Gutierrez-Roelens, Hamdani, Hartvigsen, Hayashida, Hernandez, Higashino, Hirose, Hoyland, Hummel, Hustmyer, Ikeda, Indo, Irmgard Tegeder, Jayamanne, Jim, Jörn Lötsch, Kales, Kalichman, Karppinen, Karsak, Kawaguchi, Kawaguchi, Kawasaki, Khoromi, Kim, Kim, Kim, Kim, Kirchheiner, Kirchheiner, Klepstad, Knoeringer, Kroslak, Kuisma, Kung, Lafreniere, Landau, Langdahl, Le Maitre, Lee, Lettre, Leyne, Lichtman, Liem, Lorenzo, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lovlie, Lu, Luoma, Lötsch, MacDonald, Macpherson, Madadi, Manning, McNamara, Meeus, Meller, Meller, Mignat, Mio, Miura, Mogil, Mogil, Morrison, Nguyen, Noponen-Hietala, Noponen-Hietala, Oakley, Oertel, Oertel, Oertel, Ofek, Ohtori, Oliveira, Paassilta, Papafili, Pilotto, Pluijm, Poulsen, Racz, Racz, Rakvag, Ralston, Ralston, Reyes-Gibby, Richards, Riviere, Roddier, Romberg, Russo, Sachse, Sakai, Schmidt, Schneider, Seki, Seki, Sindrup, Sipe, Skarke, Skarke, Slade, Slaugenhaupt, Solovieva, Solovieva, Solovieva, Solovieva, Solovieva, Srinivasan, Srinivasan, Stamer, Stamer, Steward, Stohler, Suzuki, Svendsen, Tadic, Takahashi, Tam, Tander, Tegeder, Tegeder, Thieme, Thomas, Trevisani, Uitterlinden, Ujike, van Meurs, Vargas-Alarcon, Verhoeven, Videman, Videman, Virtanen, Voronov, Vree, Wiesinger, Yamada, Yazdanpanah, Zhang, Zhang, Zhang, Zhang, Zubieta, Zuo   +200 more
core   +1 more source

Regulation of Melanogenesis in Skin Epidermal Keratinocytes via Activation of α7 Nicotinic Acetylcholine Receptor on the Expression of α‐Melanocyte‐Stimulating Hormone

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
α7 nAChR modulates UVB‐induced α‐MSH production during melanogenesis. UVB irradiation induces DNA damage in epidermal keratinocytes, causing upregulation of POMC transcription via the increase of its transcription factor p53, which in turn leads to elevated α‐MSH mastering melanin synthesis in epidermal melanocytes.
Maggie Suisui Guo, Xiaoyang Wang, Yingjie Xia, Jiahui Wu, Ajiaikebaier Dilidaer, Jin Gao, Tina Tingxia Dong, Karl Wah Keung Tsim   +7 more
wiley   +1 more source

Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-Backcross Charolais x Holstein population [PDF]

, 2007
Background: In cattle, the gene coding for the melanocortin receptor 1 (MCIR) is known to be the main regulator of the switch between the two coat colour pigments: eumelanin (black pigment) and phaeomelanin (red pigment).
Gutierrez-Gil, Beatriz, Wiener, Pamela, Williams, John L.   +2 more
core   +2 more sources

Epistatic interactions between at least three loci determine the “rat-tail” phenotype in cattle [PDF]

, 2016
BACKGROUND: The “rat-tail” syndrome (RTS) is an inherited hypotrichosis in cattle, which is exclusively expressed in diluted coloured hair. The affected animals also suffer from disturbed thermoregulation, which impairs their health and growth ...
Christa Kuehn, Frieder Hadlich, Jacqueline Knaust, Rosemarie Weikard   +3 more
core   +6 more sources

Melanocortin 1 Receptor: Structure, Function and Regulation

Frontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell, Mary Catherine Boulanger, John August D'orazio   +2 more
doaj   +1 more source