Results 11 to 20 of about 12,611 (227)

MC1R gene variants involvement in human OCA phenotype

Open Life Sciences, 2016
Oculocutaneous albinism (OCA) is a genetic disorder of melanin synthesis that results in hypopigmentation in hair, skin and eyes. OCA has been reported in individuals from all ethnic backgrounds but it is more common among those with Europeans ancestry ...
Saleha Shamim, Khan Taj Ali, Zafar Shaista   +2 more
doaj   +2 more sources

Pig Coat Color Manipulation by MC1R Gene Editing. [PDF]

Int J Mol Sci, 2022
Black coat color in pigs is determined by the dominant E allele at the MC1R locus. Through comparing MC1R gene sequences between recessive e and dominant ED1 alleles, we identified four missense mutations that could affect MC1R protein function for eumelanin synthesis.
Zhong H, Zhang J, Tan C, Shi J, Yang J, Cai G, Wu Z, Yang H.   +7 more
europepmc   +3 more sources

Polymorphisms in the Melanocortin-1 Receptor (Mc1R) Gene in Vitiligo

Balkan Medical Journal, 2012
Objective: Vitiligo is a progressive skin pigmentation disorder, which may be acquired or hereditary, frequently seen, and may influence every age group. The melanocortin 1 receptor (MC1R) gene is a major determinant of human pigmentation.
Eylem Acar, Gökay Bozkurt, Adnan Görgülü   +2 more
doaj   +5 more sources

Signature of balancing selection at the MC1R gene in Kunming dog populations. [PDF]

PLoS ONE, 2013
Coat color in dog breeds is an excellent character for revealing the power of artificial selection, as it is extremely diverse and likely the result of recent domestication.
Guo-dong Wang, Lu-guang Cheng, Ruo-xi Fan, David M Irwin, Shu-sheng Tang, Jian-guo Peng, Ya-ping Zhang   +6 more
doaj   +4 more sources

Differentiating Pigs from Wild Boars Based on NR6A1 and MC1R Gene Polymorphisms. [PDF]

Animals (Basel), 2021
This preliminary study aimed to differentiate domestic pigs from wild boars based on MC1R and NR6A1 polymorphisms and to identify admixture between these genomes. We studied samples obtained from wild boars from two regions of Poland and five pig breeds: Polish Landrace, Polish Large White, Złotnicka White, Pulawska and Duroc.
Koseniuk A, Smołucha G, Natonek-Wiśniewska M, Radko A, Rubiś D.   +4 more
europepmc   +5 more sources

The MC1R Gene and Youthful Looks [PDF]

Current Biology, 2016
Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for
Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., Heemst, D. van, Murray, P.G., Wollstein, A., Craen, A.J.M. de, Uh, H.W., Zeng, C.Q., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., Gunn, D.A.   +19 more
openaire   +5 more sources

MC1R gene: comparison between different farm animal species [PDF]

Italian Journal of Animal Science, 2005
Coat colour genes in farm animals have only been studied at molecular level over the last ten years, starting with Klungland et al. in 1995. Among the genes involved in pigmentation, MC1R, previously known as Extension locus, revealed polymorphisms related to red and black coat colour in different farm animal species.
P. Crepaldi, F. Fornarelli, M. Marilli
openaire   +2 more sources

Allelic variation of melanocortin-1 receptor locus in Saudi indigenous sheep exhibiting different color coats [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective This study was designed to characterize the DNA polymorphisms of the melanocortin-1 receptor (MC1R) gene in indigenous Saudi Arabian sheep breeds exhibiting different color coats, along with individuals of the Sawaknee breed, an exotic sheep ...
Ahmed H. Mahmoud, Ashraf M. Mashaly, Ahmed M. Rady, Khalid M. Al-Anazi, Amgad A. Saleh   +4 more
doaj   +1 more source

The MC1R gene in the guppy (Poecilia reticulata): Genotypic and phenotypic polymorphisms

BMC Research Notes, 2011
Background The guppy (Poecilia reticulata) is an important model organism for studying sexual selection; male guppies have complex and conspicuous pigmentation, and female guppies exhibit preferences for males with specific color spots. Understanding the
Yokoyama Jun, Yamamoto Hiroaki, Tezuka Ayumi, van Oosterhout Cock, Kawata Masakado   +4 more
doaj   +1 more source

Association of MC1R Variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study [PDF]

, 2010
<p><b>Background</b> Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes,
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core   +2 more sources