Results 51 to 60 of about 12,611 (227)

Multiple origins of melanism in two species of North American tree squirrel (Sciurus)

BMC Evolutionary Biology, 2019
Background While our understanding of the genetic basis of convergent evolution has improved there are still many uncertainties. Here we investigate the repeated evolution of dark colouration (melanism) in eastern fox squirrels (Sciurus niger; hereafter “
Helen R. McRobie, Nancy D. Moncrief, Nicholas I. Mundy   +2 more
doaj   +1 more source

<i>MC1R</i> and <i>IRF4</i> Gene Variants Are Associated with p16INK4a-Positive Epidermal Cells. [PDF]

JID Innov
Basal cell carcinoma (BCC) cases in sun-protected skin are estimated to be between 20 and 33% of total cases, highlighting a non-UVR influence on BCC incidence. In this study, we tested the hypothesis that BCC risk is associated with cell senescence in sun-protected skin by comparing senescence marker p16INK4a cell counts in skin biopsies from ...
Murdoch JV, Noordam R, Slagboom PE, van Heemst D, Gunn DA.   +4 more
europepmc   +4 more sources

Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in South Europeans [PDF]

, 2013
In humans, the geographical apportionment of the coding diversity of the pigmentary locus melanocortin-1 receptor (MC1R) is, unusually, higher in Eurasians than in Africans.
Alonso, Santos, Boyano, Dolores, de la Rúa, Concepción, Flores, Carlos, García de Galdeano, Alicia, García, Oscar, Gardeazabal, Jesús, Ibarrola-Villava, Maider, Izagirre, Neskuts, López, Saioa, Martinez-Cadenas, Conrado, Pino-Yanes, M ., Ribas, Gloria, Sevilla, Arrate, Smith-Zubiaga, I.   +14 more
core   +2 more sources

Molecular and functional basis of phenotypic convergence in white lizards at White Sands [PDF]

, 2014
There are many striking examples of phenotypic convergence in nature, in some cases associated with changes in the same genes. But even mutations in the same gene may have different biochemical properties and thus different evolutionary consequences ...
Hoekstra, Hopi E., Rompler, H., Rosenblum, E. B., Schoneberg, T.   +3 more
core   +1 more source

Global consensus on the management of melanin hyperpigmentation disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A global Delphi consensus of 10 dermatology experts established evidence‐based recommendations for melanin hyperpigmentation disorders, providing unified classification, photoprotection guidance and treatment algorithms. This framework harmonizes terminology and supports individualized management across diverse skin types and health systems.
Thierry Passeron, Seemal R. Desai, Marwa Abdallah, Firas Al‐Niaimi, Ncoza Dlova, Pearl E. Grimes, Jorge Ocampo‐Candiani, Rashmi Sarkar, Leihong Flora Xiang, Helio Amante Miot   +9 more
wiley   +1 more source

Polymorphism in MC1R, TYR and ASIP genes in different colored feather chickens [PDF]

3 Biotech, 2019
Coat color genetics successfully adapted and applied to different animal species, which provides a good demonstration of the concept of comparative genetics. In this study, we sequenced 945 bp fragments of melanocortin 1 receptor (MC1R) gene, 421 bp fragments of exon 1 of tyrosinase (TYR) gene and 266 bp fragments of exon 3 of agouti signaling protein (
Chao-Wu, Yang, Jin-Shan, Ran, Chun-Lin, Yu, Mo-Han, Qiu, Zeng-Rong, Zhang, Hua-Rui, Du, Qing-Yun, Li, Xia, Xiong, Xiao-Yan, Song, Bo, Xia, Chen-Ming, Hu, Yi-Ping, Liu, Xiao-Song, Jiang   +12 more
openaire   +2 more sources

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, EarlyView.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: Study design and methods for pooling results of genetic epidemiological studies [PDF]

, 2012
Background: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease.
Cornelius, Lynn, et al,
core   +9 more sources

A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk. [PDF]

, 2017
Despite the recent identification of some novel risk genes for Alzheimer's disease (AD), the genetic etiology of late-onset Alzheimer's disease (LOAD) remains largely unknown.
Alcolea, Daniel, Antonell, Anna, Badenas Orquin, Celia, Clarimón, Jordi, Fernandez-Santiago, Rubén, Fortea Ormaechea, Juan, Lladó Plarrumaní, Albert, Lleó Bisa, Alberto, Molinuevo, José Luis, Plana, Estel, Potrony Mateu, Míriam, Puig Butillé, Joan Anton, Puig i Sardà, Susana, Sánchez del Valle Díaz, Raquel, Tell Martí, Gemma   +14 more
core   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source