Results 81 to 90 of about 12,611 (227)

Mechanism of Mitf inhibition and morphological differentiation effects of hirsein A on B16 melanoma cells revealed by DNA microarray [PDF]

, 2012
BackgroundWe have previously reported that hirsein A inhibits melanogenesis in B16 melanoma cells by downregulating the Mitf gene expression.ObjectiveIn this study, microarray was employed to determine the transcriptional response of B16 cells to hirsein
Han Junkyu, Ikuta Kenjiro, Isoda Hiroko, Villareal Myra O., 礒田 博子, 韓 畯奎   +5 more
core   +1 more source

Pigments, Chromatophore Structure, and Gene Expression Underlying Colour Polytypy of a Panamanian Poison Frog

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki, Giselle Tamayo‐Castillo, Víctor Vásquez‐Cháves, Abel Mora‐Machado, William J. Zamora Ramirez, Roberto Ibáñez, Heike Pröhl, Ariel Rodríguez   +7 more
wiley   +1 more source

Commercial Application of Porcine MC1R Gene Polymorphisms to Korean Pork Industry [PDF]

Journal of Animal Science and Technology, 2009
The pork from black-coated pigs is famous among-consumers for better eating quality. The loci affecting black coat color was identified in pig chromosome 6 in which several genetic effects on pork quality have been reported. The melanocortin 1 receptor (MC1R) gene is a major gene which plays a key role in regulation of eumelanin (black/brown) and ...
You-Kyoung Ha, Jung-Suk Choi, Sang-Wook Kim, Yang-Il Choi, Seug-Soo Lee, Jae-Won Choi, Soon-Hong Jeon, Kwan-Suk Kim   +7 more
openaire   +1 more source

A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties

Skin Research and Technology, Volume 32, Issue 1, January 2026.
ABSTRACT Background With increasing life expectancy, the aging population, particularly in Asia, is expanding rapidly. Combined with intense year‐round ultraviolet exposure, this accelerates skin aging. Male skin also exhibits distinct aging characteristics.
Mingkwan Na Takuathung, Kantirat Yaja, Jakkrit Aisara, Preeyaporn Klinjan, Pannita Anek, Ratchanon Inpan, Tattiya Kantasa, Jeeraporn Chitphan, Kankanit Yeerong, Supanimit Teekachunhatean, Nut Koonrungsesomboon   +10 more
wiley   +1 more source

Análise de polimorfismos do gene MC1R associados a fenótipos humanos de pigmentação na população brasileira.

Saúde, Ética & Justiça, 2013
Dentre os genes conhecidos por infl uenciarem a variação normal de pigmentação de olhos, pele e cabelos em humanos, o gene MC1R (receptor de melanocortina 1) é o mais bem caracterizado até o momento.
LA Marano, AL Simões, EA Donadi, CT Mendes-Junior   +3 more
doaj  

A Diagnosis of Dysplastic Naevus has no Clinical Relevance and Unnecessarily Confounds Therapeutic Decision‐Making

JEADV Clinical Practice, Volume 4, Issue 5, Page 969-981, December 2025.
ABSTRACT The term ‘dysplastic naevus’ first introduced in 1980, has since engendered considerable debate regarding its ontological legitimacy, the appropriateness of its nomenclature, and its potential prognostic significance. In this review, we undertake a critical examination of the extant literature, including a focus on the past decade.
Cliff Rosendahl, Simon Clark, Syril Keena T. Que, Denis Moir, Harald Kittler, Jane M. Grant‐Kels   +5 more
wiley   +1 more source

Effects of melanocortin 1 receptor (MC1R) gene polymorphisms on plumage color in mule ducks

Revista Brasileira de Zootecnia
The objective of the present study was to investigate the effect of single nucleotide polymorphism (SNP) of the melanocortin 1 receptor (MC1R) gene on plumage coloration in mule ducks.
Yi-Chen Tu, Liang-Yuan Wei, Yi-Ying Chang, Hsiu-Chou Liu, Hsien-Hsiung Lee, Yu-Hsiang Yu, Ming-Cheng Chen   +6 more
doaj   +1 more source

Six Years of Genetic Diagnosis of Severe Early‐Onset Obesity in a French Cohort

Obesity Science &Practice, Volume 11, Issue 6, December 2025.
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
M. Rama, E. Blond, A. Janin, M. Di‐Filippo, C. Cuerq, O. Marmontel, P. A. Rollat‐Farnier, E. Dieterlen, B. Segrestin, M. Nicolino, E. Disse, K. Perge, D. Collin‐Chavagnac   +12 more
wiley   +1 more source

The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder occurring in women of reproductive age. The disease is caused by a complex interplay of genetic and environmental factors including genes encoding components of the hypothalamic ...
Rongling Wu, Claudia Gragnoli
doaj   +1 more source

Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: a cross-sectional study [PDF]

PeerJ, 2017
Background Early detection and treatment are the most important elements in reducing the incidence of melanoma deaths. Acquired melanocytic naevi (AMN) are well-known precursors of melanoma but most of our knowledge on the clinico-dermoscopic phenotypes ...
Xiaohong Li, Katie J. Lee, David L. Duffy, Dandan Xu, Madhur Eshwar Rao Basude, Ying Hu, Hang Zhang, Kasturee Jagirdar, H. Peter Soyer, Huiting Dong, Richard A. Sturm   +10 more
doaj   +2 more sources