Results 131 to 140 of about 10,319 (179)

The effect of melanocortin-4 receptor agonist drugs on obesity and metabolic risk factors: a systematic review and meta-analysis. [PDF]

Diabetol Metab Syndr
Sun Y, Abed M, Sohouli MH.
europepmc   +1 more source

In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss. [PDF]

Obes Surg
Hany M, ElDeeb MK, Elmongui E, Abouelnasr AA, El-Banna NA, Omer SM, Shaker SA, ElTahan RA.   +7 more
europepmc   +1 more source

Interplay Between Enteroendocrine Hormone (Leptin) and Adipokines (Ghrelin and Adiponectin) with Gastric Expression of FTO and MC4R Genes. [PDF]

Sci Rep
Hany M, ElDeeb MK, Elmongui E, Abouelnasr AA, El-Banna NA, Omer SM, Shaker SA, ElTahan RA.   +7 more
europepmc   +1 more source

The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters. [PDF]

J Cell Sci
Parashara P, Gao L, Riglos A, Lartey D, Sidhu SB, Marks T, Williams C, Siauw G, Lee KJ, Ostrem AIL, Siebold C, Riffle M, Kinnebrew M, Gunn TM, Kong JH.   +14 more
europepmc   +1 more source

Immune System Controls Gut Bacterial and Host Peptide Signals in Appetite Regulation: Towards Specific Immunotherapy of Eating Disorders.

Neuroimmunomodulation
Fetissov SO.
europepmc   +1 more source

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MC4R in Central and Peripheral Systems

Advanced Biology, 2023
AbstractObesity has emerged as a critical and urgent health burden during the current global pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in food intake and energy metabolism regulation through various signaling pathways, has been reported to be the lead genetic factor in severe and early onset obesity and ...
Ran Wei, Danjie Li, Sheng Jia, Yuhong Chen, Jiqiu Wang   +4 more
openaire   +2 more sources

MC4R Agonists: Structural Overview on Antiobesity Therapeutics

Trends in Pharmacological Sciences, 2018
The melanocortin-4 receptor (MC4R) regulates adipose tissue formation and energy homeostasis, and is believed to be a monogenic target for novel antiobesity therapeutics. Several research efforts targeting this receptor have identified potent and selective agonists.
Morten Meldal, Juliana P L Gonçalves, Daniel Palmer   +2 more
exaly   +4 more sources

β-Alanine dipeptides as MC4R agonists

Bioorganic & Medicinal Chemistry Letters, 2003
beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.
Réjean, Ruel, Timothy F, Herpin, Lawrence, Iben, Guanglin, Luo, Alain, Martel, Helen, Mason, Gail, Mattson, Brigitte, Poirier, Edward H, Ruediger, Dan, Shi, Carl, Thibault, Guixue, Yu, Ildiko, Antal Zimanyi, Graham S, Poindexter, John E, Macor   +14 more
openaire   +2 more sources