Results 141 to 150 of about 10,319 (179)

MC4R neurons weigh in differently

Nature Neuroscience, 2006
Food intake and energy expenditure were thought to be simultaneously controlled by the same group of neurons, but now new evidence shows that they are independently regulated by an anatomically distinct set of melanocortin neurons.
Allison W Xu, Gregory S Barsh
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Molecular Genetics of Human Obesity‐Associated MC4R Mutations [PDF]

Annals of the New York Academy of Sciences, 2003
Abstract: Heterozygous coding mutations in the melanocortin 4 receptor (MC4R) are implicated in 1 to 6% of early onset or severe adult obesity cases. To better address the problem of the genotype:phenotype relationship within this specific form of obesity, we systematically studied the functional characteristics of 50 different obesity‐associated MC4R
Lubrano-Berthelier, Cecile, Cavazos, Martha, Dubern, Beatrice, Shapiro, Astrid, Stunff, Catherine L E, Zhang, Sumei, Picart, Franck, Govaerts, Cedric, Froguel, Philippe, Bougneres, Pierre, Clement, Karine, Vaisse, Christian   +11 more
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Increased constraints on MC4R during primate and human evolution

Human Genetics, 2008
The melanocortin 4 receptor (MC4R) is routinely investigated for the role it plays in human obesity, as mutations in MC4R are the most common dominantly inherited form of the disease. As little is known about the evolutionary history of this locus, we investigated patterns of variation at MC4R in a worldwide sample of 1,015 humans from 51 populations ...
Johannes Hebebrand, Anke Hinney, Mark Stoneking   +2 more
exaly   +6 more sources

MC4R oligomerizes independently of extracellular cysteine residues

Peptides, 2006
The melanocortin 4 receptor (MC4R) plays an essential role in weight regulation. Recently we could show that the MC4R is able to form receptor dimers. In the present study we investigated the role of extracellular cysteine residues and the structure of the third extracellular loop for receptor dimerization.
Andrea, Elsner, Patrick, Tarnow, Michael, Schaefer, Petra, Ambrugger, Heiko, Krude, Annette, Grüters, Heike, Biebermann   +6 more
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From a Cone Snail Toxin to a Competitive MC4R Antagonist

Journal of Medicinal Chemistry, 2022
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonists, such as setmelanotide used to treat rare forms of genetic obesity.
Reynaud, Steve, Laurin, Suli-Anne, Ciolek, Justyna, Barbe, Peggy, van Baelen, Anne-Cécile, Susset, Michaël, Blondel, Florian, Ghazarian, Marine, Boeri, Julia, Vanden Driessche, Margot, Upert, Grégory, Mourier, Gilles, Kessler, Pascal, Konnert, Laure, Beroud, Rémy, Keck, Mathilde, Servent, Denis, Bouvier, Michel, Gilles, Nicolas   +18 more
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β‐Alanine Dipeptides as MC4R Agonists.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Rejean Ruel, et al. et al.
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Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity

Journal of Medicinal Chemistry, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi P, Nargund, Alison M, Strack, Tung M, Fong   +2 more
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???????????????????? ???????????????????? ???????????? ?????????????? ?????????? ???????????? ???? ???????????? ESR ???? MC4R

2021
The genetic structure of Large White pigs breed of farm ???Kalityansky Bacon??? fromKiev region was analyzed by genes ESR and MC4R during 2006???2009 years. The frequencyof economically beneficial allele by ESR gene, was fluctuated from 0,32 to 0,59. Thefrequency of economically useful allele of the gene MC4R was fluctuated from 0,50 to 0,70.
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Abstract 5933: Identifying MC4R-targeted small molecule to investigate MC4R impact on cachexia progression

Cancer Research
Abstract Background: The melanocortin system participates in energy homeostasis and appetiteregulation. This metabolic system is primarily located in the central nervous system,specifically in the hypothalamus and brainstem region. Within the melanocortin system,there are five established melanocortin receptors (MCR).
Julia Stokes, Dhanir Tailor, Marie Foss, Benedikt Grau, Sanjay Malhotra   +4 more
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Polymorphisms in MC4R gene and correlations with economic traits in cattle

Molecular Biology Reports, 2010
MC4R contributes to the control of food intake and energy expenditure, and single nucleotide polymorphisms (SNPs) in the MC4R gene have clearly been associated with backfat depth, feed intake and growth rate in pig. Our objectives were to scan the complete coding region by sequencing in samples from eight cattle breeds, to estimate the frequency of the
Meng, Huang, Xue, Gao, Jun Ya, Li, Hong Yan, Ren, Jin Bao, Chen, Shang Zhong, Xu   +5 more
openaire   +2 more sources