Results 241 to 250 of about 124,045 (313)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Fenugreek inhibits cathepsin G activity and suppresses the progression of malignant phenotypes in MCF-7 cells. [PDF]

Biochem Biophys Rep
Tanigawa K, Tanikawa T, Kitamura M, Hayashi Y, Kiriya M, Nakamura Y, Kawashima A, Fujiwara Y, Morimoto-Kamata R, Ohkura N, Yui S, Karasawa K, Nakamura R, Suzuki K.   +13 more
europepmc   +1 more source

Mechanochemical Treatment of Cellulose: A Strategy for Developing Functional Biocomposite Materials

Polymer Engineering &Science, EarlyView.
Mechanochemistry as an integrated approach for combining fiber defibrillation, activation, surface functionalization, and cellulose‐based composite fabrication in a single or reduced number of steps. ABSTRACT Cellulose‐based biocomposites are attracting increasing scientific and industrial interest due to their sustainable origin, biodegradability, and
Murilo O. da Luz, Otávio Bianchi, Sandro Campos Amico, Fernanda T. G. Dias   +3 more
wiley   +1 more source

Naringenin Inhibits Cellular Proliferation, Arrests Cell Cycle and Induces Pro-Apoptotic Autophagy in MCF-7 Breast Cancer Cells. [PDF]

J Cell Mol Med
Mir SA, Bhat BA, Shenoy PS, Hamid L, Nisar N, Dar A, Ray P, Bader GN.   +7 more
europepmc   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Selective apoptosis induction by antimicrobial peptide TP4 in MCF-7 breast cancer cells. [PDF]

Sci Rep
Ardeshir RA, Moarefvand K.
europepmc   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

Synergistic targeting of cancer-related proteins by benzyl isothiocyanate and caffeic acid: MLSD and cytotoxic mechanisms in MCF-7 cells. [PDF]

3 Biotech
Rahaman MHA, Azlan NAA, Alam M, Kadir NHA.   +3 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Exploring the anticancer potential of green silver Nanoparticles-Paclitaxel nanocarrier on MCF-7 breast Cancer cells: an in vitro approach. [PDF]

Sci Rep
Aboul-Nasr MB, Yasien AA, Mohamed SS, Aboul-Nasr YB, Obiedallah M.   +4 more
europepmc   +1 more source