Results 111 to 120 of about 2,946 (205)

MCPyV LT-t is not bound or destabilized by Fbw7.

, 2019
(A) Whole cell lysates of 293A cells transfected with individual or combinations of FLAG-Fbw7 (4.5μg), ΔFbox (3μg), HA-SV40 LT (5μg), MCPyV LT-t (10.5μg), were pulled-down with XT10, and immunoblotted with anti-FLAG.
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023Capsule Summary

JAAD International
Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.
Maria Vygovska, MD, David Hoyt, BS, Ashley M. Snyder, PhD, MPH, Thorarinn Jonmundsson, MSc, Ashley Khouri, BS, Dev Ram Sahni, MD, MHA, Jonathan Ungar, MD, Jesse M. Lewin, MD, Nicholas Gulati, MD, PhD, Robert G. Phelps, MD, Vikram N. Sahni, MD, Jane M. Grant-Kels, MD, Helgi Sigurdsson, MD, Jon Gunnlaugur Jonasson, MD, Jonas A. Adalsteinsson, MD, PhD   +14 more
doaj   +1 more source

080 Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy [PDF]

Journal of Investigative Dermatology, 2016
T. Walradt, V. Makarov, R. Doumani, N. Riaz, K. Stafstrom, A. Moshiri, L. Yelistratova, J. Levinsohn, T. Chan, P. Nghiem, R. Lifton, J. Choi   +11 more
openaire   +1 more source

Antibody positivity to MCPyV by age and gender in rural Anyang, China, 2007–2009.

, 2014
NOTE. MCPyV: Merkel cell polyomavirus.aP values for trend were derived by logistic regression analyses considering categorical variables as continuous variables.Antibody positivity to MCPyV by age and gender in rural Anyang, China, 2007–2009.
Fangfang Liu (185161), Chuanhai Guo (185167), Qiuju Deng (5660470), Ying Liu (18461), Yongmei Liang (625275), Zhonghu He (185165), Yang Ke (166836), Lixin Zhang (55947), Chanyuan Zhang (625273), Chaoting Zhang (625274), Ruiping Xu (573406), Yaqi Pan (166801), Tao Ning (166806), Hong Cai (166815)   +13 more
core   +1 more source

Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Biomedicines
Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses.
Sara Passerini, Giulia Babini, Elisabetta Merenda, Raffaella Carletti, Daniela Scribano, Luigi Rosa, Antonietta Lucia Conte, Ugo Moens, Livia Ottolenghi, Umberto Romeo, Maria Pia Conte, Cira Rosaria Tiziana Di Gioia, Valeria Pietropaolo   +12 more
doaj   +1 more source

MCPyV genome is episomal in non-pathogenic skin samples.

, 2013
A, Schematic representation of the sequenced regions (overlapping sequences 1 to 9) mapped on MCPyV circular DNA. B, Agarose gel of the PCR products obtained from patient P18 skin sample DNA using the sequencing primer sets targeting sequence 1 to 9; WM,
Sébastien Corre (62241), Na Guo (198794), Alain Fautrel (209374), Laurent Misery (363611), Nicolas Mouchet (186275), Henri Adamski (248466), Eric Watier (248477), Ariane Mogha (149686), Marie-Dominique Galibert (62246)   +8 more
core   +1 more source

MCPyV-transformed cells exhibit elevated ECAR and sensitivity to MCT1 inhibitors.

, 2016
A) Anchorage-independent growth of IMR90 PH, PHL, PHE and PHEL cells. ****P B) Basal ECAR (mpH/min) measurement of p53DD, PH, PHE and PHE + MYCL (PHEL) cells. **P C) Proliferation of PHEL cells treated with DMSO, CHC (5 mM), SR13800 (100 nM), or SR13801 (
James A. DeCaprio (127469), Christian Berrios (127454), Vadim Molla (3359798), Jingwei Cheng (127458), Soo Mi Lee (3359804), John Quackenbush (1213), Megha Padi (127447), Mark A. Keibler (3359801), Gregory Stephanopoulos (122663), Donglim Esther Park (3359795)   +9 more
core   +1 more source

MCPyV ST increases LT protein levels independently of Fbw7, but dependent on the LSD.

, 2019
(A) A co-immunoprecipitation between MCPyV T antigens (LT, ST, ST ΔLSD) and Fbw7 was performed through pull-down of the T antigens (XT10—common-T antibody) and detection of co-immunoprecipitated Fbw7 (anti-FLAG).
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Time course of expression of MCPyV-VP1.

, 2015
Insect Tn5 cells were infected with AcMCPyV-VP1 and harvested for the indicated time periods. Five microliters of culture medium and samples of lysate from 105 cells were analyzed by SDS-PAGE. Protein bands were visualized by Coomassie blue staining (CB;
Michiyo Kataoka (485324), Tetsuro Suzuki (180340), Noriyo Nagata (389752), Naokazu Takeda (290583), Kenji Iwasaki (352584), Harutaka Katano (249978), Kazumi Kobayashi (691493), Tetsuya Mizutani (58974), Takaji Wakita (109321), Tian-Cheng Li (691492)   +9 more
core   +1 more source

Role of Merkel cell polyomavirus (MCPyV) T antigens in carcinogenesis [PDF]

Polyomavirus Merkelových buněk (MCPyV) je virus s dvouřetězcovým DNA genomem, který způsobuje nejčastěji bezpříznakovou primární infekci, po které dochází k ustavení perzistence a virus se stává součástí běžné kožní mikroflóry. Za určitých okolností může
Ryšavá, Kateřina
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