Results 91 to 100 of about 3,812 (207)

Merkel cell polyomavirus (MCPyV) in the context of Immunosuppression. Genetic analysis of noncoding control region (NCCR) variability among a HIV-1-positive population [PDF]

, 2020
Background: Since limited data are available about the prevalence of Merkel cell polyomavirus (MCPyV) and the genetic variability of its noncoding control region (NCCR) in the context of immunosuppression, this study aimed to investigate the distribution
Ambroselli, D, Andreoni, M, Checconi, P, Ciotti, M, Coppola, L, de Vito, C, Nardi, A, Obregon, F, Palamara, AT, Petrolo, S, Pietropaolo, V., Prezioso, C, Rodio, DM, Sarmati, L   +13 more
core   +1 more source

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
wiley   +1 more source

A short intrinsically disordered domain of MCPyV ALTO regulates host TBK1 signaling and MCPyV latency

Abstract Merkel Cell Polyomavirus (MCPyV) is an oncogenic human polyomavirus that latently infects most adults. Although the causative link between MCPyV and Merkel Cell Carcinoma (MCC) is well established, the molecular mechanisms that govern viral latency and prevent oncogenic progression remain poorly understood.
Taylor E. Senay, Xiaomei Li, Sneha G. Shirhattikar, Tiana T. Luo, Jianxin You   +4 more
openaire   +2 more sources

Presence of Merkel cell polyomavirus DNA and large-T antigen in keratinocyte carcinomas and its correlation with immunohistochemical markers p16, p53 and ki67 [PDF]

Anais Brasileiros de Dermatologia
Background Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and cutaneous squamous ...
T.R. Bellott, Flávio Barbosa Luz, Anna Karoline Fausto da Silva, Rafael Brandão Varella, Mayra Carrijo Rochael, Rafaela Elvira Rozza-de-Menezes, Luciana Pantaleão   +6 more
doaj   +1 more source

Pleural Metastasis of Merkel Cell Carcinoma

Diagnostic Cytopathology, Volume 53, Issue 6, Page 308-311, June 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often challenging to diagnose due to its morphological resemblance to other malignancies. Diagnosis is typically confirmed by immunohistochemistry (IHC), with most cases being positive for both neuroendocrine and epithelial markers, particularly the characteristic
Sina Maghsoudlou, Marc Pusztaszeri, Mauro Saieg   +2 more
wiley   +1 more source

Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Cervical cancer (CxCa) is primarily caused by high-risk human papillomaviruses (hrHPV), which disrupt p53 and pRb regulation, leading to uncontrolled growth and progression.
Fatemeh Pakdel, Seyed Masoud Hosseini, Neda Soleimani, Ali Farhadi   +3 more
doaj   +1 more source

Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas [PDF]

, 2014
Merkel cell carcinoma (MCC) is an aggressive, virus-associated, neuroendocrine tumor of the skin mainly affecting immunocompromised patients. Higher intratumoral infiltration with CD3 and CD8 positive T-cells is associated with a better prognosis ...
Behr, Daniel S., Dollt, Claudia, Goebeler, Matthias, Goerdt, Sergij, Hametner, Christian, Houben, Roland, Lasitschka, Felix, Marx, Alexander, Michel, Julia, Peitsch, Wiebke K., Schmieder, Astrid, Schönhaar, Kathrin   +11 more
core  

Animal Viruses, Bacteria, and Cancer: A Brief Commentary [PDF]

, 2014
Animal viruses and bacteria are ubiquitous in the environment. However, little is known about their mode of transmission and etiologic role in human cancers, especially among high-risk groups (e.g., farmers, veterinarians, poultry plant workers, pet ...
Anderson, Ethan J., Davies, Stephen W., Efird, Jimmy T., NC DOCKS at East Carolina University, O’Neal, Wesley T.   +4 more
core   +2 more sources

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, Volume 2, Issue 2, June 2025.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

Depicting CREB-Dependent Transcriptome in MCPyV+ and MCPyV- Merkel Cell Carcinoma Cells

, 2021
Merkel Cell Carcinoma (MCC) is a highly malignant neuroendocrine tumor with an increasing incidence and the highest mortality rate amongst skin cancers (30%). They are usually diagnosed at advanced stages and still lack precise markers for diagnosis. MCC has two main etiologies: polyomavirus-positive (MCPyV+) and -negative (MCPyV-).
openaire   +1 more source