Results 91 to 100 of about 3,161 (168)

Characterization of immune responses to human polyomavirus MCPyV. [PDF]

, 2013
Characterization of immune responses to human polyomavirus MCPyV There have been considerable increase in number of known human polyomaviruses in recent years; currently we register twelve of them.
Vochozková, Petra
core  

Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions()

, 2023
BACKGROUND: Human Polyomaviruses such as MCPyV and HPyV6 are frequently found as part of healthy skin microbiota and have been associated with Merkel cell carcinoma (MCC), pruritic and dyskeratotic dermatoses, respectively.
Luz, Flavio B., Costa, Gabriella R.M. da, Guimarães, Maria Angelica A.M., Varella, Rafael B., Venceslau, Marianna T.   +4 more
core   +1 more source

Inhibition of NF-κB activity represses MCPyV EP-driven viral oncogene expression, which is lethal in MCPyV+ MCC.

, 2023
(A) HEK293 cells stably expressing an MCPyV EP-luciferase reporter were treated with DMSO or 25 μM JSH-23 for 72h before EP-driven luciferase expression was measured by luciferase assay. (B) PETA and (C) MKL-1 cells were treated with DMSO or 25 μM JSH-23
Jianxin You (121729), June F. Yang (16907650), Wei Liu (20030)   +2 more
core   +1 more source

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.

PLoS Pathogens
While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV ...
Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, Jianxin You   +7 more
doaj   +1 more source

Increased Detection of Merkel Cell Polyomavirus in Non-Melanoma Skin Cancer and Its Association with Host Immunogenetic Profile

Dermato
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in Merkel cell carcinoma (MCC), yet its role in other cutaneous neoplasms remains under investigation. The impact of the host’s immunogenetic characteristics on the
Leonardo Ribeiro Alves de Souza, Camila Freze Baez, Thiago Rubim Bellott, Milena Siqueira Pereira, Marianna Tavares Venceslau Gonçalves, Maria Angelica Arpon Marandino Guimarães, Flávio Barbosa Luz, Rafael Brandão Varella   +7 more
doaj   +1 more source

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Journal of Experimental & Clinical Cancer Research, 2019
Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates.
Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay   +6 more
doaj   +1 more source

Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study

Discover Oncology
Merkel Cell Polyomavirus (MCPyV) is recognized as the major aetiological agent of Merkel Cell Carcinoma (MCC), an aggressive skin tumor. MCPyV-mediated oncogenesis is strictly dependent on viral integration and the expression of a truncated form of the ...
Sara Passerini, Matteo Fracella, Amedeo Ferlosio, Ugo Moens, Carolina Scagnolari, Guido Antonelli, Marco Ciotti, Valeria Pietropaolo   +7 more
doaj   +1 more source

Newly discovered KI, WU, and Merkel cell polyomaviruses: No evidence of mother-to-fetus transmission

Virology Journal, 2010
Background Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown.
Taskinen Helena, Karikoski Riitta, Surcel Heljä-Marja, Kantola Kalle, Chen Tingting, Väisänen Elina, Riipinen Anita, Sadeghi Mohammadreza, Söderlund-Venermo Maria, Hedman Klaus   +9 more
doaj   +1 more source

Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023Capsule Summary

JAAD International
Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.
Maria Vygovska, MD, David Hoyt, BS, Ashley M. Snyder, PhD, MPH, Thorarinn Jonmundsson, MSc, Ashley Khouri, BS, Dev Ram Sahni, MD, MHA, Jonathan Ungar, MD, Jesse M. Lewin, MD, Nicholas Gulati, MD, PhD, Robert G. Phelps, MD, Vikram N. Sahni, MD, Jane M. Grant-Kels, MD, Helgi Sigurdsson, MD, Jon Gunnlaugur Jonasson, MD, Jonas A. Adalsteinsson, MD, PhD   +14 more
doaj   +1 more source

ELISA reactivity of 10 neutralizing anti-MCPyV positive human sera (MCC patients) against MCPyV insertional mutants BC, DE, EF and HI.

, 2015
In order to characterize the epitopes of the MCPyV VP1, the reactivity of the human sera was analyzed from ten patients using the MCPyV wt VP1 VLPs and the four mutants with insertion within the BC, DE, EF and HI VP1 loops.
Jérôme T. J. Nicol (561901), Françoise Arnold (323720), Thierry Moreau (210181), Mahtab Samimi (713207), Hélène Gonneville (713211), Nicolas Combelas (713212), Olivier Mercey (713210), Maxime J. J. Fleury (713206), Jean-Francois Vautherot (5662810), Pierre Coursaget (561903), Antoine Touzé (323722), Raphaelle Ballaire (713209), Gérard Lorette (442136), Raphael Cazal (713208)   +13 more
core   +1 more source