Results 91 to 100 of about 2,946 (205)

An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, Volume 52, Issue 9, Page 554-567, September 2025.
ABSTRACT Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cell with aggressive clinical behavior and involves multiple organ systems, including the skin. LCS is characterized by marked cytologic atypia, frequent mitoses including atypical ones, and expression of CD1a, S100, and langerin (CD207).
Randa Obid, Austin R. Green, Sion W. Jasmine, Rachel P. Kowal, Brooj Abro, Laura M. Warmke, Magdalena B. Czader, Ahmed K. Alomari, Carina A. Dehner   +8 more
wiley   +1 more source

HDACi treatment upregulates MCPyV EP-driven transcription.

, 2023
HEK293 cells were transfected with pTRIPZ MCPyV EP-luciferase, and then treated with DMSO, 1 μM SAHA, 100 nM TSA, 1 μM Belinostat, 100 nM Panobinostat, or 250 nM Romidepsin at 8h post-transfection.
Jianxin You (121729), June F. Yang (16907650), Wei Liu (20030)   +2 more
core   +1 more source

Structural Analysis of Merkel Cell Polyomavirus (MCPyV) Viral Capsid Protein (VP1) in HIV-1 Infected Individuals [PDF]

, 2020
Merkel cell polyomavirus (MCPyV) viral protein 1 (VP1) is the capsid protein that mediates virus attachment to host cell receptors and is the major immune target.
Carla Prezioso, Palamara, Anna Teresa, Moens, Ugo, Anna Teresa Palamara, Sarmati, Loredana, Marco Ciotti, Loredana Sarmati, Valeria Pietropaolo, Pascarella, Stefano, Obregon, Francisco, Stefano Pascarella, Francisco Obregon, Bianchi, Martina, Martina Bianchi, Ugo Moens, Pietropaolo, Valeria, Ciotti, Marco, Prezioso, Carla, Andreoni, Massimo, Massimo Andreoni   +19 more
core   +1 more source

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
wiley   +1 more source

A short intrinsically disordered domain of MCPyV ALTO regulates host TBK1 signaling and MCPyV latency

Abstract Merkel Cell Polyomavirus (MCPyV) is an oncogenic human polyomavirus that latently infects most adults. Although the causative link between MCPyV and Merkel Cell Carcinoma (MCC) is well established, the molecular mechanisms that govern viral latency and prevent oncogenic progression remain poorly understood.
Taylor E. Senay, Xiaomei Li, Sneha G. Shirhattikar, Tiana T. Luo, Jianxin You   +4 more
openaire   +2 more sources

MCPyV LT is not bound or destabilized by the WD40 domain of Fbw7.

, 2019
(A) MCPyV LT was pulled-down from whole cell lysates of 293A cells transfected with MCPyV LT (5μg), LT-t (10.5μg) and either the FLAG-Fbw7α (4.5μg), or HA-Fbw7α construct (8μg).
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Presence of Merkel cell polyomavirus DNA and large-T antigen in keratinocyte carcinomas and its correlation with immunohistochemical markers p16, p53 and ki67 [PDF]

Anais Brasileiros de Dermatologia
Background Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and cutaneous squamous ...
T.R. Bellott, Flávio Barbosa Luz, Anna Karoline Fausto da Silva, Rafael Brandão Varella, Mayra Carrijo Rochael, Rafaela Elvira Rozza-de-Menezes, Luciana Pantaleão   +6 more
doaj   +1 more source

Pleural Metastasis of Merkel Cell Carcinoma

Diagnostic Cytopathology, Volume 53, Issue 6, Page 308-311, June 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often challenging to diagnose due to its morphological resemblance to other malignancies. Diagnosis is typically confirmed by immunohistochemistry (IHC), with most cases being positive for both neuroendocrine and epithelial markers, particularly the characteristic
Sina Maghsoudlou, Marc Pusztaszeri, Mauro Saieg   +2 more
wiley   +1 more source

Characterization of immune responses to human polyomavirus MCPyV. [PDF]

, 2013
Characterization of immune responses to human polyomavirus MCPyV There have been considerable increase in number of known human polyomaviruses in recent years; currently we register twelve of them.
Vochozková, Petra
core  

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Emerging Infectious Diseases, 2009
Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62 ...
Ulrike Wieland, Cornelia Mauch, Alexander Kreuter, Thomas Krieg, Herbert Pfister   +4 more
doaj   +1 more source