Results 101 to 110 of about 2,946 (205)

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, Volume 2, Issue 2, June 2025.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma

Endocrine Pathology
Abstract Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and detection of Merkel cell polyomavirus (MCPyV) using various methods.
Yeni Erdem, Begum, Baykal, Can, Ozluk, Yasemin, Ahmed, Melin A., Kozanoglu, Erol, Saip, Pinar, Buyukbabani, Nesimi, Ozturk Sari, Sule   +7 more
openaire   +2 more sources

Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin

PLoS ONE, 2013
The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown.
Meijden, E. van der, Bialasiewicz, S., Rockett, R.J., Tozer, S.J., Sloots, T.P., Feltkamp, M.C.W.   +5 more
openaire   +8 more sources

ELISA reactivity of 10 neutralizing anti-MCPyV positive human sera (MCC patients) against MCPyV insertional mutants BC, DE, EF and HI.

, 2015
In order to characterize the epitopes of the MCPyV VP1, the reactivity of the human sera was analyzed from ten patients using the MCPyV wt VP1 VLPs and the four mutants with insertion within the BC, DE, EF and HI VP1 loops.
Jérôme T. J. Nicol (561901), Françoise Arnold (323720), Thierry Moreau (210181), Mahtab Samimi (713207), Hélène Gonneville (713211), Nicolas Combelas (713212), Olivier Mercey (713210), Maxime J. J. Fleury (713206), Jean-Francois Vautherot (5662810), Pierre Coursaget (561903), Antoine Touzé (323722), Raphaelle Ballaire (713209), Gérard Lorette (442136), Raphael Cazal (713208)   +13 more
core   +1 more source

The Rb^ΔL mutation in pRb disrupts its interaction with MCPyV LT but does not affect K14-directed expression of MCPyV T antigens in the skin of mice.

, 2022
A) Co-immunoprecipitation and immunoblot analysis of the MCPyV large T antigen (LT) and pRb. 293FT cells were transfected with pcDNA-dsRed plasmid (none), pRbWT only, pRbΔL only, a MCPyV-168ER expression construct expressing the MCPyV168 early region ...
Ella Ward-Shaw (12542830), Jingwei Cheng (127458), Paul F. Lambert (266676), James A. DeCaprio (8597283), Frederick A. Dick (12542833), Megan E. Spurgeon (12542827)   +5 more
core   +1 more source

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.

PLoS Pathogens
While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV ...
Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, Jianxin You   +7 more
doaj   +1 more source

Increased Detection of Merkel Cell Polyomavirus in Non-Melanoma Skin Cancer and Its Association with Host Immunogenetic Profile

Dermato
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in Merkel cell carcinoma (MCC), yet its role in other cutaneous neoplasms remains under investigation. The impact of the host’s immunogenetic characteristics on the
Leonardo Ribeiro Alves de Souza, Camila Freze Baez, Thiago Rubim Bellott, Milena Siqueira Pereira, Marianna Tavares Venceslau Gonçalves, Maria Angelica Arpon Marandino Guimarães, Flávio Barbosa Luz, Rafael Brandão Varella   +7 more
doaj   +1 more source

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Journal of Experimental & Clinical Cancer Research, 2019
Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates.
Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay   +6 more
doaj   +1 more source

Newly discovered KI, WU, and Merkel cell polyomaviruses: No evidence of mother-to-fetus transmission

Virology Journal, 2010
Background Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown.
Taskinen Helena, Karikoski Riitta, Surcel Heljä-Marja, Kantola Kalle, Chen Tingting, Väisänen Elina, Riipinen Anita, Sadeghi Mohammadreza, Söderlund-Venermo Maria, Hedman Klaus   +9 more
doaj   +1 more source

Supplemental Figure 2. Kaplan Meier analysis of survival among MCPyV+ and MCPyV- patients according to the density, composition and distribution of the inflammatory infiltrate. from Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

, 2016
Survival according to CD3 density/mm2 at the periphery (left), center (middle), and hotspot (right) in MCPyV+ MCCs (Top row) versus MCPyV- MCCs (Second row).
Jaime Rodriguez-Canales (436827), Victor G. Prieto (4419790), Jennifer S. Ko (14901644), Genevieve Ray-Lyons (15003338), Barbara Mino (7045535), Priyadharsini Nagarajan (267957), Pei-Ling Chen (4255105), Jonathan L. Curry (14997137), Carlos A. Torres-Cabala (15003344), Ignacio I. Wistuba (9603546), Phyu P. Aung (15003341), Laurence Feldmeyer (11975747), Alexandre Reuben (148071), Roland L. Bassett (14984948), Zachary A. Cooper (14916234), Steven D. Billings (14971953), Jennifer A. Wargo (14899857), Courtney W. Hudgens (15003335), Michael T. Tetzlaff (10133735)   +18 more
core   +1 more source