Results 101 to 110 of about 3,812 (207)

Long-Term Sustained Disease Control with Immunotherapy in Chemotherapy-Refractory Merkel Cell Carcinoma

healthbook TIMES. Oncology Hematology, 2019
Merkel cell carcinoma (MCC) is a rare and difficult-to-treat cutaneous malignancy with a poor prognosis. Treatment protocols for localized MCC are well established.
Deborah Zihler, Kathrin Vollmer, Antonio Cozzio   +2 more
doaj   +1 more source

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Emerging Infectious Diseases, 2009
Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62 ...
Ulrike Wieland, Cornelia Mauch, Alexander Kreuter, Thomas Krieg, Herbert Pfister   +4 more
doaj   +1 more source

非小細胞肺がんにおける腫瘍特異的特徴を有するメルケル細胞ポリオーマウイルスの検出 [PDF]

平成27年3月23日授与　甲総医博第27号　橋田　裕美子氏学位申請論文　要約原文掲載： Br J Cancer. 2013 Feb 19;108(3):629-37. doi: 10.1038/bjc.2012.567.
ハシダ,　ユミコ, 橋田,　裕美子   +1 more
core   +1 more source

Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma

Endocrine Pathology
Abstract Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and detection of Merkel cell polyomavirus (MCPyV) using various methods.
Yeni Erdem, Begum, Baykal, Can, Ozluk, Yasemin, Ahmed, Melin A., Kozanoglu, Erol, Saip, Pinar, Buyukbabani, Nesimi, Ozturk Sari, Sule   +7 more
openaire   +2 more sources

Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin

PLoS ONE, 2013
The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown.
Meijden, E. van der, Bialasiewicz, S., Rockett, R.J., Tozer, S.J., Sloots, T.P., Feltkamp, M.C.W.   +5 more
openaire   +7 more sources

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.

PLoS Pathogens
While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV ...
Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, Jianxin You   +7 more
doaj   +1 more source

Increased Detection of Merkel Cell Polyomavirus in Non-Melanoma Skin Cancer and Its Association with Host Immunogenetic Profile

Dermato
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in Merkel cell carcinoma (MCC), yet its role in other cutaneous neoplasms remains under investigation. The impact of the host’s immunogenetic characteristics on the
Leonardo Ribeiro Alves de Souza, Camila Freze Baez, Thiago Rubim Bellott, Milena Siqueira Pereira, Marianna Tavares Venceslau Gonçalves, Maria Angelica Arpon Marandino Guimarães, Flávio Barbosa Luz, Rafael Brandão Varella   +7 more
doaj   +1 more source

Replication, Gene Expression and Particle Production by a Consensus Merkel Cell Polyomavirus (MCPyV) Genome

PLoS ONE, 2011
Merkel Cell Polyomavirus (MCPyV) genomes are clonally integrated in tumor tissues of approximately 85% of all Merkel cell carcinoma (MCC) cases, a highly aggressive tumor of the skin which predominantly afflicts elderly and immunosuppressed patients. All integrated viral genomes recovered from MCC tissue or MCC cell lines harbor signature mutations in ...
Friederike Neumann, Sophie Borchert, Claudia Schmidt, Rudolph Reimer, Heinrich Hohenberg, Nicole Fischer, Adam Grundhoff   +6 more
openaire   +4 more sources

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Journal of Experimental & Clinical Cancer Research, 2019
Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates.
Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay   +6 more
doaj   +1 more source

Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023Capsule Summary

JAAD International
Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.
Maria Vygovska, MD, David Hoyt, BS, Ashley M. Snyder, PhD, MPH, Thorarinn Jonmundsson, MSc, Ashley Khouri, BS, Dev Ram Sahni, MD, MHA, Jonathan Ungar, MD, Jesse M. Lewin, MD, Nicholas Gulati, MD, PhD, Robert G. Phelps, MD, Vikram N. Sahni, MD, Jane M. Grant-Kels, MD, Helgi Sigurdsson, MD, Jon Gunnlaugur Jonasson, MD, Jonas A. Adalsteinsson, MD, PhD   +14 more
doaj   +1 more source