Results 101 to 110 of about 3,161 (168)

MCPyV LT-t is not bound or destabilized by Fbw7.

, 2019
(A) Whole cell lysates of 293A cells transfected with individual or combinations of FLAG-Fbw7 (4.5μg), ΔFbox (3μg), HA-SV40 LT (5μg), MCPyV LT-t (10.5μg), were pulled-down with XT10, and immunoblotted with anti-FLAG.
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Biomedicines
Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses.
Sara Passerini, Giulia Babini, Elisabetta Merenda, Raffaella Carletti, Daniela Scribano, Luigi Rosa, Antonietta Lucia Conte, Ugo Moens, Livia Ottolenghi, Umberto Romeo, Maria Pia Conte, Cira Rosaria Tiziana Di Gioia, Valeria Pietropaolo   +12 more
doaj   +1 more source

Supplemental Figure 2. Kaplan Meier analysis of survival among MCPyV+ and MCPyV- patients according to the density, composition and distribution of the inflammatory infiltrate. from Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

, 2016
Survival according to CD3 density/mm2 at the periphery (left), center (middle), and hotspot (right) in MCPyV+ MCCs (Top row) versus MCPyV- MCCs (Second row).
Jaime Rodriguez-Canales (436827), Victor G. Prieto (4419790), Jennifer S. Ko (14901644), Genevieve Ray-Lyons (15003338), Barbara Mino (7045535), Priyadharsini Nagarajan (267957), Pei-Ling Chen (4255105), Jonathan L. Curry (14997137), Carlos A. Torres-Cabala (15003344), Ignacio I. Wistuba (9603546), Phyu P. Aung (15003341), Laurence Feldmeyer (11975747), Alexandre Reuben (148071), Roland L. Bassett (14984948), Zachary A. Cooper (14916234), Steven D. Billings (14971953), Jennifer A. Wargo (14899857), Courtney W. Hudgens (15003335), Michael T. Tetzlaff (10133735)   +18 more
core   +1 more source

MCPyV genome is episomal in non-pathogenic skin samples.

, 2013
A, Schematic representation of the sequenced regions (overlapping sequences 1 to 9) mapped on MCPyV circular DNA. B, Agarose gel of the PCR products obtained from patient P18 skin sample DNA using the sequencing primer sets targeting sequence 1 to 9; WM,
Sébastien Corre (62241), Na Guo (198794), Alain Fautrel (209374), Laurent Misery (363611), Nicolas Mouchet (186275), Henri Adamski (248466), Eric Watier (248477), Ariane Mogha (149686), Marie-Dominique Galibert (62246)   +8 more
core   +1 more source

Antibody positivity to MCPyV by age and gender in rural Anyang, China, 2007–2009.

, 2014
NOTE. MCPyV: Merkel cell polyomavirus.aP values for trend were derived by logistic regression analyses considering categorical variables as continuous variables.Antibody positivity to MCPyV by age and gender in rural Anyang, China, 2007–2009.
Fangfang Liu (185161), Chuanhai Guo (185167), Qiuju Deng (5660470), Ying Liu (18461), Yongmei Liang (625275), Zhonghu He (185165), Yang Ke (166836), Lixin Zhang (55947), Chanyuan Zhang (625273), Chaoting Zhang (625274), Ruiping Xu (573406), Yaqi Pan (166801), Tao Ning (166806), Hong Cai (166815)   +13 more
core   +1 more source

MCPyV ST increases LT protein levels independently of Fbw7, but dependent on the LSD.

, 2019
(A) A co-immunoprecipitation between MCPyV T antigens (LT, ST, ST ΔLSD) and Fbw7 was performed through pull-down of the T antigens (XT10—common-T antibody) and detection of co-immunoprecipitated Fbw7 (anti-FLAG).
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Replication, gene expression and particle production by a consensus Merkel Cell Polyomavirus (MCPyV) genome.

, 2011
Merkel Cell Polyomavirus (MCPyV) genomes are clonally integrated in tumor tissues of approximately 85% of all Merkel cell carcinoma (MCC) cases, a highly aggressive tumor of the skin which predominantly afflicts elderly and immunosuppressed patients. All
Sophie Borchert, Schmidt Claudia, Hohenberg Heinrich, Friederike Neumann, Fischer Nicole, Adam Grundhoff, Nicole Fischer, Neumann Friederike, Heinrich Hohenberg, Grundhoff Adam, Borchert Sophie, Reimer Rudolph, Rudolph Reimer, Claudia Schmidt   +13 more
core   +1 more source

Role of Merkel cell polyomavirus (MCPyV) T antigens in carcinogenesis [PDF]

Polyomavirus Merkelových buněk (MCPyV) je virus s dvouřetězcovým DNA genomem, který způsobuje nejčastěji bezpříznakovou primární infekci, po které dochází k ustavení perzistence a virus se stává součástí běžné kožní mikroflóry. Za určitých okolností může
Ryšavá, Kateřina
core  

Deciphering Host-Pathogen Interactions Governing Merkel Cell Polyomavirus (MCPyV) Life Cycle and Disease Pathogenesis

This dissertation investigates critical gaps in our understanding of the biology of Merkel Cell Polyomavirus (MCPyV), a recently discovered human polyomavirus (PyV) that causes Merkel cell carcinoma (MCC), an aggressive neuroendocrine skin cancer.
Wang, Karen
core   +1 more source

Merkel Cell Polyomavirus and DNA Damage Response. [PDF]

Int J Mol Sci
Passerini S, Messina S, Moens U, Pietropaolo V.   +3 more
europepmc   +1 more source