Results 81 to 90 of about 3,161 (168)
, 2022 A) Representative images of MCPyV-RbWT (top) and MCPyV-RbΔL (bottom) mice on the FVB/N genetic background at 6 months of age. The black arrowheads highlight two representative spontaneous skin tumors arising on the skin of MCPyV-RbWT mice.
Ella Ward-Shaw (12542830) +5 more
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The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities
Human Mutation, Volume 2026, Issue 1, 2026.Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou +3 more
wiley +1 more source
MCPyV LT-t and ST do not interact with the E3 ubiquitin ligase Fbw1 (β-TrCP).
, 2019 (A) Fbw1, was assessed for its ability to co-immunoprecipitate MCPyV T antigens. 293A cells co-transfected with individual or combinations of Fbw7 (4.5μg), Fbw1 (3μg), MCPyV LT (5μg), MCPyV LT-t (10.5μg), or MCPyV ST (1μg).
Kristine N. Dye (6270047) +4 more
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Presence of Merkel cell polyomavirus DNA and large-T antigen in keratinocyte carcinomas and its correlation with immunohistochemical markers p16, p53 and ki67 [PDF]
Anais Brasileiros de DermatologiaBackground Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and cutaneous squamous ...
T.R. Bellott +6 more
doaj +1 more source
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Human cytomegalovirus (CMV) and BK polyomavirus are archetypal latent DNA viruses that establish lifelong persistence and cause severe disease upon reactivation in immunocompromised hosts. Although they differ markedly in virion architecture, genome size, and coding capacity, both viruses converge on a shared biological principle: durable persistence ...
Luobin Robin Zheng +3 more
wiley +1 more source
Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma
Emerging Infectious Diseases, 2009 Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62 ...
Ulrike Wieland +4 more
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Distribution of the seroresponses for MCPyV by age and gender.
, 2014 Presented are seroresponses of 5548 healthy adults aged 25–65 years who were enrolled from rural Anyang, China, 2007–2009. The strength of the antibody reactions was plotted against the percentile according to age and gender.
Fangfang Liu (185161) +13 more
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MCPyV VP1 insertional mutants BC, DE, EF and HI.
, 2015 A) MCPyV surface exposed loops model generated using the MKT21 sequence with the VP1 structure information of MCPyV w162 strain (4FMG pdb file) by Swiss-Model.
Jérôme T. J. Nicol (561901) +13 more
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HDACi treatment upregulates MCPyV EP-driven transcription.
, 2023 HEK293 cells were transfected with pTRIPZ MCPyV EP-luciferase, and then treated with DMSO, 1 μM SAHA, 100 nM TSA, 1 μM Belinostat, 100 nM Panobinostat, or 250 nM Romidepsin at 8h post-transfection.
Jianxin You (121729) +2 more
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MCPyV LT is not bound or destabilized by the WD40 domain of Fbw7.
, 2019 (A) MCPyV LT was pulled-down from whole cell lysates of 293A cells transfected with MCPyV LT (5μg), LT-t (10.5μg) and either the FLAG-Fbw7α (4.5μg), or HA-Fbw7α construct (8μg).
Kristine N. Dye (6270047) +4 more
core +1 more source