Results 81 to 90 of about 3,812 (207)

Characterization of self-assembled virus-like particles of Merkel cell polyomavirus.

PLoS ONE, 2015
In our recombinant baculovirus system, VP1 protein of merkel cell polyomavirus (MCPyV), which is implicated as a causative agent in Merkel cell carcinoma, was self-assembled into MCPyV-like particles (MCPyV-LP) with two different sizes in insect cells ...
Tian-Cheng Li, Kenji Iwasaki, Harutaka Katano, Michiyo Kataoka, Noriyo Nagata, Kazumi Kobayashi, Tetsuya Mizutani, Naokazu Takeda, Takaji Wakita, Tetsuro Suzuki   +9 more
doaj   +1 more source

Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer

Frontiers in Immunology, 2020
Virus positive Merkel cell carcinoma (VP-MCC) is an aggressive but immunogenic skin malignancy driven by Merkel cell polyomavirus (MCPyV) T antigen (TAg). Since adoptive T cell transfer (ACT) can be effective against virus-driven malignancies, we set out
Sarah I. Davies, Sarah I. Davies, Sarah I. Davies, John Barrett, Susan Wong, Mark Jesse Chang, Pawel J. Muranski, Pawel J. Muranski, Isaac Brownell   +8 more
doaj   +1 more source

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma [PDF]

, 2017
BACKGROUND: Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection.
Bohling, T., Kero, M., Knuutila, S., Koljonen, V., Sarhadi, Virinder Kaur, Veija, T.   +5 more
core   +1 more source

The microbiome in cancer

iMeta, Volume 4, Issue 5, October 2025.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source

Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Virology Journal, 2021
Background Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and ...
Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens   +2 more
doaj   +1 more source

Serum IgG antibodies from pregnant women reacting to mimotopes of simian virus 40 large T antigen, the viral oncoprotein [PDF]

, 2017
Simian virus 40 (SV40) large T antigen (LT) coding sequences were revealed in different human samples, whereas SV40 antibodies (Ab) were detected in human sera of cancer patients and healthy individuals, although with a lower prevalence. Previous studies
Casali, Maria V., Destro, Federica, Di Stefano, Mariantonietta, Fiore, Josè R., Greco, Pantaleo, Manfrini, Marco, Martini, Fernanda, Mazzoni, Elisa, Rotondo, John Charles, Scutiero, Gennaro, Tognon, Mauro G., Vesce, Fortunato   +11 more
core   +2 more sources

Cytokeratin and Neuroendocrine Positivity in Cutaneous Small Blue Round Cell Tumor—Is It Always Merkel Cell Carcinoma?

Journal of Cutaneous Pathology, Volume 52, Issue 10, Page 605-610, October 2025.
ABSTRACT We present a case of a 39‐year‐old woman initially diagnosed with Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine carcinoma, due to the presence of cytokeratin and neuroendocrine marker expression. The tumor was dermal based, showing small round blue cells with fine chromatin, scant cytoplasm, and scattered mitotic figures ...
Simon Moubarak, John McAfee, Karen Fritchie, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, Volume 52, Issue 9, Page 554-567, September 2025.
ABSTRACT Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cell with aggressive clinical behavior and involves multiple organ systems, including the skin. LCS is characterized by marked cytologic atypia, frequent mitoses including atypical ones, and expression of CD1a, S100, and langerin (CD207).
Randa Obid, Austin R. Green, Sion W. Jasmine, Rachel P. Kowal, Brooj Abro, Laura M. Warmke, Magdalena B. Czader, Ahmed K. Alomari, Carina A. Dehner   +8 more
wiley   +1 more source

Detection of Malawi polyomavirus sequences in secondary lymphoid tissues from Italian healthy children: a transient site of infection [PDF]

, 2016
BACKGROUND: The novel Malawi polyomavirus (MWPyV) was initially detected in stool specimens from healthy children and children with gastrointestinal symptoms, mostly diarrhea, indicating that MWPyV might play a role in human gastroenteric diseases ...
Comar, M, Knowles, A, Orzan, E, Papa, N, Zanotta, N   +4 more
core   +2 more sources