Results 81 to 90 of about 2,946 (205)

Distribution of the seroresponses for MCPyV by age and gender.

, 2014
Presented are seroresponses of 5548 healthy adults aged 25–65 years who were enrolled from rural Anyang, China, 2007–2009. The strength of the antibody reactions was plotted against the percentile according to age and gender.
Fangfang Liu (185161), Chuanhai Guo (185167), Qiuju Deng (5660470), Ying Liu (18461), Yongmei Liang (625275), Zhonghu He (185165), Yang Ke (166836), Lixin Zhang (55947), Chanyuan Zhang (625273), Chaoting Zhang (625274), Ruiping Xu (573406), Yaqi Pan (166801), Tao Ning (166806), Hong Cai (166815)   +13 more
core   +1 more source

Characterization of self-assembled virus-like particles of Merkel cell polyomavirus.

PLoS ONE, 2015
In our recombinant baculovirus system, VP1 protein of merkel cell polyomavirus (MCPyV), which is implicated as a causative agent in Merkel cell carcinoma, was self-assembled into MCPyV-like particles (MCPyV-LP) with two different sizes in insect cells ...
Tian-Cheng Li, Kenji Iwasaki, Harutaka Katano, Michiyo Kataoka, Noriyo Nagata, Kazumi Kobayashi, Tetsuya Mizutani, Naokazu Takeda, Takaji Wakita, Tetsuro Suzuki   +9 more
doaj   +1 more source

The microbiome in cancer

iMeta, Volume 4, Issue 5, October 2025.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source

Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Virology Journal, 2021
Background Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and ...
Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens   +2 more
doaj   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source

MCPyV copy number in various skin tumors.

, 2012
(A) Digital PCR software-generated composite heat maps showing chambers with positive signals for both control RNaseP genes (blue) and MCPyV (red). Digital PCR heat maps are indicated in the upper panel for Merkel cell carcinoma case 6, in the middle ...
Yutaka Takazawa (154682), Satoshi Ota (154675), Shumpei Ishikawa (154679), Takeshi Fujii (154686), Ken-ichi Ohashi (154690), Masashi Fukayama (154693), Akiteru Goto (138036)   +6 more
core   +1 more source

The interaction between pRb and the MCPyV large T antigen is required for spontaneous tumor development in murine skin.

, 2022
A) Representative images of MCPyV-RbWT (top) and MCPyV-RbΔL (bottom) mice on the FVB/N genetic background at 6 months of age. The black arrowheads highlight two representative spontaneous skin tumors arising on the skin of MCPyV-RbWT mice.
Ella Ward-Shaw (12542830), Jingwei Cheng (127458), Paul F. Lambert (266676), James A. DeCaprio (8597283), Frederick A. Dick (12542833), Megan E. Spurgeon (12542827)   +5 more
core   +1 more source

Cytokeratin and Neuroendocrine Positivity in Cutaneous Small Blue Round Cell Tumor—Is It Always Merkel Cell Carcinoma?

Journal of Cutaneous Pathology, Volume 52, Issue 10, Page 605-610, October 2025.
ABSTRACT We present a case of a 39‐year‐old woman initially diagnosed with Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine carcinoma, due to the presence of cytokeratin and neuroendocrine marker expression. The tumor was dermal based, showing small round blue cells with fine chromatin, scant cytoplasm, and scattered mitotic figures ...
Simon Moubarak, John McAfee, Karen Fritchie, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

MCPyV VP1 insertional mutants BC, DE, EF and HI.

, 2015
A) MCPyV surface exposed loops model generated using the MKT21 sequence with the VP1 structure information of MCPyV w162 strain (4FMG pdb file) by Swiss-Model.
Jérôme T. J. Nicol (561901), Françoise Arnold (323720), Thierry Moreau (210181), Mahtab Samimi (713207), Hélène Gonneville (713211), Nicolas Combelas (713212), Olivier Mercey (713210), Maxime J. J. Fleury (713206), Jean-Francois Vautherot (5662810), Pierre Coursaget (561903), Antoine Touzé (323722), Raphaelle Ballaire (713209), Gérard Lorette (442136), Raphael Cazal (713208)   +13 more
core   +1 more source

Inhibition of NF-κB activity represses MCPyV EP-driven viral oncogene expression, which is lethal in MCPyV+ MCC.

, 2023
(A) HEK293 cells stably expressing an MCPyV EP-luciferase reporter were treated with DMSO or 25 μM JSH-23 for 72h before EP-driven luciferase expression was measured by luciferase assay. (B) PETA and (C) MKL-1 cells were treated with DMSO or 25 μM JSH-23
Jianxin You (121729), June F. Yang (16907650), Wei Liu (20030)   +2 more
core   +1 more source