Results 71 to 80 of about 3,161 (168)

Characterization of self-assembled virus-like particles of Merkel cell polyomavirus.

PLoS ONE, 2015
In our recombinant baculovirus system, VP1 protein of merkel cell polyomavirus (MCPyV), which is implicated as a causative agent in Merkel cell carcinoma, was self-assembled into MCPyV-like particles (MCPyV-LP) with two different sizes in insect cells ...
Tian-Cheng Li, Kenji Iwasaki, Harutaka Katano, Michiyo Kataoka, Noriyo Nagata, Kazumi Kobayashi, Tetsuya Mizutani, Naokazu Takeda, Takaji Wakita, Tetsuro Suzuki   +9 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

ELISA reactivity of MCPyV monoclonal antibodies against MCPyV insertional mutants BC, DE, EF and HI.

, 2015
In order to characterize the epitopes of the MCPyV VP1, the reactivity of mAbs was analyzed using the MCPyV wt VP1 VLPs and the four mutants with insertion within the BC, DE, EF and HI VP1 loops. ELISAs were performed using hybridoma culture supernatants
Jérôme T. J. Nicol (561901), Françoise Arnold (323720), Thierry Moreau (210181), Mahtab Samimi (713207), Hélène Gonneville (713211), Nicolas Combelas (713212), Olivier Mercey (713210), Maxime J. J. Fleury (713206), Jean-Francois Vautherot (5662810), Pierre Coursaget (561903), Antoine Touzé (323722), Raphaelle Ballaire (713209), Gérard Lorette (442136), Raphael Cazal (713208)   +13 more
core   +1 more source

Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Virology Journal, 2021
Background Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and ...
Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens   +2 more
doaj   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Competitive inhibition of seroreactivity between MCPyV, PtvPyV1 and PtvPyV2.

, 2014
ELISA Reactivity against MCPyV, PtvPyV1 and PtvPyV2 was determined for five human (A) and five chimpanzee (B) sera after preincubation with or without MCPyV, PtvPyV1 or PtvPyV VLPs. Percentage of inhibition after preincubation is indicated above bars.
Jérôme T. J. Nicol (561901), Pierre Coursaget (561903), Mauro Tognon (311647), Etienne Liais (561902), Antoine Touzé (323722), Romain Potier (385822), Elisa Mazzoni (407132)   +6 more
core   +1 more source

superT in MCPyV-associated MCC.

, 2022
A. Sanger sequencing of an RT-PCR product from MCC J45_440, showing the superT-specific junction. B. A schematic detailing the MCC 285 MCPyV integration site, showing how it is possible that superT is generated via cis-splicing. C.
Michael J. Imperiale (12334399), Chandreyee Datta (12334396), Gabriel J. Starrett (2741878), Matthew Meyerson (24538), Wei Zou (107458), Thomas C. Frost (12334393), Shobha Vasudevan (8433183), James A. DeCaprio (8597283), Jason Nomburg (8597259)   +8 more
core   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

MCPyV copy number in various skin tumors.

, 2012
(A) Digital PCR software-generated composite heat maps showing chambers with positive signals for both control RNaseP genes (blue) and MCPyV (red). Digital PCR heat maps are indicated in the upper panel for Merkel cell carcinoma case 6, in the middle ...
Yutaka Takazawa (154682), Satoshi Ota (154675), Shumpei Ishikawa (154679), Takeshi Fujii (154686), Ken-ichi Ohashi (154690), Masashi Fukayama (154693), Akiteru Goto (138036)   +6 more
core   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source