Results 71 to 80 of about 2,946 (205)

ELISA reactivity of MCPyV monoclonal antibodies against MCPyV insertional mutants BC, DE, EF and HI.

, 2015
In order to characterize the epitopes of the MCPyV VP1, the reactivity of mAbs was analyzed using the MCPyV wt VP1 VLPs and the four mutants with insertion within the BC, DE, EF and HI VP1 loops. ELISAs were performed using hybridoma culture supernatants
Jérôme T. J. Nicol (561901), Françoise Arnold (323720), Thierry Moreau (210181), Mahtab Samimi (713207), Hélène Gonneville (713211), Nicolas Combelas (713212), Olivier Mercey (713210), Maxime J. J. Fleury (713206), Jean-Francois Vautherot (5662810), Pierre Coursaget (561903), Antoine Touzé (323722), Raphaelle Ballaire (713209), Gérard Lorette (442136), Raphael Cazal (713208)   +13 more
core   +1 more source

The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal

Virology Journal
Background Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a novel polyomavirus, Merkel Cell Polyomavirus (MCPyV ...
Kaira R. Thevenin, Isabella S. Tieche, Cody E. Di Benedetto, Matt Schrager, Kristine N. Dye   +4 more
doaj   +1 more source

Prognostic Factors Influencing Oncologic Outcomes in Merkel Cell Carcinoma: A Retrospective Population‐Based Cohort Study

Journal of Skin Cancer, Volume 2026, Issue 1, 2026.
Aim/Objectives Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with a poorly understood etiology and lacking high‐level evidence to guide its management. This study examined the presentation and outcome related to MCC treatment at a Canadian center.
Megan McDonald, Vibhay Pareek, Frances-Claire Eichorn, Arbind Dubey, Alok Pathak, Richa Sharma   +5 more
wiley   +1 more source

The role of MCPyV ST in Merkel cell carcinoma metastasis [PDF]

, 2017
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity for metastasis via the dermal lymphatic system.
Nwogu, Nnenna Onyinyechi Uchechi
core  

MCPyV LT-t and ST do not interact with the E3 ubiquitin ligase Fbw1 (β-TrCP).

, 2019
(A) Fbw1, was assessed for its ability to co-immunoprecipitate MCPyV T antigens. 293A cells co-transfected with individual or combinations of Fbw7 (4.5μg), Fbw1 (3μg), MCPyV LT (5μg), MCPyV LT-t (10.5μg), or MCPyV ST (1μg).
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation

mBio
Merkel cell polyomavirus (MCPyV) is a double-stranded tumor virus that is the main causative agent of Merkel cell carcinoma (MCC). The MCPyV large T antigen (LT), an essential viral DNA replication protein, maintains viral persistence by interacting with
Alexander M. Pham, Hyun Jin Kwun
doaj   +1 more source

Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer

Frontiers in Immunology, 2020
Virus positive Merkel cell carcinoma (VP-MCC) is an aggressive but immunogenic skin malignancy driven by Merkel cell polyomavirus (MCPyV) T antigen (TAg). Since adoptive T cell transfer (ACT) can be effective against virus-driven malignancies, we set out
Sarah I. Davies, Sarah I. Davies, Sarah I. Davies, John Barrett, Susan Wong, Mark Jesse Chang, Pawel J. Muranski, Pawel J. Muranski, Isaac Brownell   +8 more
doaj   +1 more source

superT in MCPyV-associated MCC.

, 2022
A. Sanger sequencing of an RT-PCR product from MCC J45_440, showing the superT-specific junction. B. A schematic detailing the MCC 285 MCPyV integration site, showing how it is possible that superT is generated via cis-splicing. C.
Michael J. Imperiale (12334399), Chandreyee Datta (12334396), Gabriel J. Starrett (2741878), Matthew Meyerson (24538), Wei Zou (107458), Thomas C. Frost (12334393), Shobha Vasudevan (8433183), James A. DeCaprio (8597283), Jason Nomburg (8597259)   +8 more
core   +1 more source

Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases

Journal of Hematology & Oncology, 2012
Background Chronic lymphocytic leukemia (CLL) is the rarest adult leukemia in Japan, whereas it is the most common leukemia in the Western world. Recent studies from the United States and Germany suggest a possible etiological association between Merkel ...
Imajoh Masayuki, Hashida Yumiko, Taniguchi Ayuko, Kamioka Mikio, Daibata Masanori   +4 more
doaj   +1 more source

Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025

The Journal of Dermatology, Volume 52, Issue 11, Page e954-e967, November 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by high rates of recurrence and metastasis. Although rare, the incidence has noticeably increased in recent years. It is also known to be a highly immunogenic tumor, and the use of immune checkpoint inhibitors has begun for advanced cases.
Motoki Nakamura, Kotaro Nagase, Junji Kato, Masahito Yasuda, Natsuo Tomita, Tadahiro Kobayashi, Keitaro Fukuda, Akihiko Yuki, Hiroshi Uchi, Hiroshi Koga, Tomomitsu Miyagaki, Yasuhiro Nakamura   +11 more
wiley   +1 more source