Results 51 to 60 of about 3,161 (168)

Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma.

PLoS Pathogens, 2010
Merkel Cell Polyomavirus (MCPyV) is associated with Merkel Cell carcinoma (MCC), a rare, aggressive skin cancer with neuroendocrine features. The causal role of MCPyV is highly suggested by monoclonal integration of its genome and expression of the viral
Hélène C Laude, Barbara Jonchère, Eve Maubec, Agnès Carlotti, Eduardo Marinho, Benoit Couturaud, Martine Peter, Xavier Sastre-Garau, Marie-Françoise Avril, Nicolas Dupin, Flore Rozenberg   +10 more
doaj   +1 more source

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment.

PLoS ONE, 2020
AimsMerkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection.
María-Dolores Mendoza, Carlos Santonja, Carmen Gonzalez-Vela, Angel Concha, Nicolás Iglesias Pena, Eva-Maria Andrés-Esteban, Jose Pedro Vaque, Laura Cereceda, Raquel Pajares, H Kutzner, Luis Requena, Miguel A Piris   +11 more
doaj   +1 more source

Merkel cell polyomavirus and associated Merkel cell carcinoma

Tumour Virus Research, 2022
Merkel cell polyomavirus (MCPyV) is a ubiquitous skin infection that can cause Merkel cell carcinoma (MCC), a highly lethal form of skin cancer with a nearly 50% mortality rate.
June F. Yang, Jianxin You
doaj   +1 more source

Merkel cell polyomavirus small T antigen mRNA level is increased following in vivo UV-radiation. [PDF]

PLoS ONE, 2010
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer involving Merkel cells. Recently, a new human polyomavirus was implicated in MCC, being present in 80% of the samples analyzed.
Ariane Mogha, Alain Fautrel, Nicolas Mouchet, Na Guo, Sébastien Corre, Henri Adamski, Eric Watier, Laurent Misery, Marie-Dominique Galibert   +8 more
doaj   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Molecular mechanisms regulating the NCRR-driven transcriptional program of MCPyV.

, 2023
p300/CBP upregulate MCPyV gene expression primarily through acetylation of the p65 subunit of NF-κB, which binds directly to kB site(s) on the NCRR. p300/CBP may also acetylate the histones associated with the viral NCRR to stimulate MCPyV transcription.
Jianxin You (121729), June F. Yang (16907650), Wei Liu (20030)   +2 more
core   +1 more source

A Snapshot of the UK Blood Donor Plasma Virome: A Retrospective Cross‐Sectional Cohort Study

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Estimates of population prevalence and genetic diversity of bloodborne viruses in healthy humans are essential to support population‐scale monitoring for transfusion transmission risk. In the UK and globally, blood donations are routinely screened for a limited number of high‐consequence pathogens, but the full composition of the plasma virome
Kai Kean, Richard M. Mayne, Kaitlin Reid, Shannah Secret, Belinda K. Singleton, Rebecca Rockett, Piya Rajendra, Heli Harvala, Judith Breuer, M. Azim Ansari, Katrina Lythgoe, Peter Simmonds, Tanya Golubchik   +12 more
wiley   +1 more source

The impact of merkel cell polyomavirus positivity on prognosis of merkel cell carcinoma: A systematic review and meta-analysis

Frontiers in Oncology, 2022
IntroductionThere are numerous findings over the past decade have indicated that Merkel cell carcinoma (MCC) may have two pathways of pathogenesis: one related to ultraviolet irradiation and the other to the Merkel cell polyomavirus (MCPyV). However, the
Aimin Yang, Wilson Adrian Wijaya, Lei Yang, Yinhai He, Ying Cen, Junjie Chen   +5 more
doaj   +1 more source

Molecular and Phylogenetic Characterization of HTLV‐1 Infection in Patients With Hematological Malignancies in the State of Pará, Northern Brazil

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Human T‐lymphotropic viruses 1 and 2 (HTLV‐1 and HTLV‐2) were first isolated from patients with hematological malignancies. This study was the first to investigate the frequency of HTLV‐1 and its molecular diversity among patients with hematolymphoid cancers who were treated at a leading reference hospital in Pará, northern Brazil.
Gabriel dos Santos Pereira Neto, Ana Vilhena Alves, Bruno José Sarmento Botelho, Andrio Silva da Silva, Debora Monteiro Carneiro, Rommel Mario Rodriguez Burbano, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Izaura Maria Vieira Cayres Vallinoto   +8 more
wiley   +1 more source

The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal

Virology Journal
Background Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a novel polyomavirus, Merkel Cell Polyomavirus (MCPyV ...
Kaira R. Thevenin, Isabella S. Tieche, Cody E. Di Benedetto, Matt Schrager, Kristine N. Dye   +4 more
doaj   +1 more source