Results 41 to 50 of about 3,812 (207)

Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes [PDF]

, 2016
It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV.
Akonkwa, DBM, Akoua-Koffi, C, Bergl, RA, Boesch, C, Calvignac-Spencer, S, Eckardt, W, Ehlers, B, Fruth, B, Gillespie, TR, Gray, M, Hohmann, G, Karhemere, S, Kujirakwinja, D, Langergraber, K, Leendertz, FH, Madinda, NF, Muyembe, J-J, Nishuli, R, Pauly, M, Peeters, M, Petrzelkova, KJ, Robbins, MM, Schubert, G, Stoinski, TS, Todd, A, Wertheim, JO, Wittig, RM, Zuberbuhler, K   +27 more
core   +2 more sources

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

Thoracic Cancer, 2019
Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic ...
Emil Chteinberg, Faisal Klufah, Dorit Rennspiess, Mick F. Mannheims, Myrurgia A. Abdul‐Hamid, Mario Losen, Marlies Keijzers, Marc H. De Baets, Anna Kordelia Kurz, Axel zur Hausen   +9 more
doaj   +1 more source

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility [PDF]

, 2018
Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K⁺ and Cl⁻ channels now being ...
Adrian Whitehouse, Andrew Macdonald, Balkwill, Baquero-Pérez, Becker, Berrios, Feng, Fernández-Salas, G. Eric Blair, Gabrielė Stakaitytė, Griffiths, Harms, Hodgson, Houben, Houben, Hover, Huber, Hughes, Igloi, Jackson, Jamel Mankouri, James R. Boyne, Jiang, Jonathan D. Lippiat, Knight, Knips, Krzysztof Poterlowicz, Kwun, Lang, Li, Malik, Mao, McLaughlin-Drubin, Moens, Nnenna Nwogu, Peretti, Ritchie, Royle, Schumann, Shuda, Smith, Srinivasan, Stakaityt, Stakaityte, Starrett, Wang, Wheat, Yao, Zhao, Zheng   +49 more
core   +2 more sources

Comparison of Quantitative Real-Time PCR and Digital PCR to Detect the Polyomavirus in Merkel Cell Carcinoma

Viruses, 2022
Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR techniques using formalin-fixed, paraffin-embedded (FFPE) tissues. The aim of this
Martina Barchitta, Andrea Maugeri, Elisabetta Campisi, Roberta Magnano San Lio, Giuliana Favara, Hector Jose Soto Parra, Lucia Salvatorelli, Gaetano Magro, Guido Basile, Antonella Agodi   +9 more
doaj   +1 more source

Merkel Cell Polyomavirus (MCPyV) and Its Possible Role in Head and Neck Cancers. [PDF]

Biomedicines
Despite significant progress in its prevention, diagnosis, and treatment, head and neck cancer (HNC) remains a major global health issue due to its multifactorial pathogenesis. Indeed, HNCs have been found to be associated with different environmental and lifestyle factors, as well as with infection with oncogenic viruses.
Passerini S, Messina S, Moens U, Pietropaolo V.   +3 more
europepmc   +4 more sources

Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel cell carcinoma [PDF]

Oncotarget, 2022
ABSTRACT Background Merkel cell carcinoma (MCC) is an aggressive skin cancer, related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. Immune checkpoint inhibitors provide sustained benefit in about half of MCC patients with advanced disease.
Muralidharan, Sujatha, Kervarrec, Thibault, Weiss, Glen J., Samimi, Mahtab   +3 more
openaire   +2 more sources

Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer

Scientific Reports, 2021
Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC ...
Monir Ghanghareh, Jalal Mosayebi Amroabadi, Seyed Mohammad Tavangar, Shiva Irani, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh   +8 more
doaj   +1 more source

MISSEL: a method to identify a large number of small species-specific genomic subsequences and its application to viruses classification [PDF]

, 2016
Continuous improvements in next generation sequencing technologies led to ever-increasing collections of genomic sequences, which have not been easily characterized by biologists, and whose analysis requires huge computational effort.
Babakir Mina, Muhammed, Bertolazzi, Paola, Cella, Eleonora, Ciccozzi, Massimo, Ciotti, Marco, Felici, Giovanni, Fiscon, Giulia, Giovanetti, Marta, Lo Presti, Alessandra, Pierangeli, Alessandra, Weitschek, Emanuel   +10 more
core   +2 more sources

Mutational Analysis of Merkel Cell Carcinoma [PDF]

, 2014
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy that is associated with a poor prognosis. The pathogenesis of MCC is not well understood, and despite a recent plethora of mutational analyses, we have yet to find a set of ...
Cusack, James C., Erstad, Derek J.
core   +2 more sources

Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC)

Pathogens, 2023
Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed on primary tumors and regional lymph nodes from two MCC patients: one metastatic and one non ...
Sara Passerini, Carla Prezioso, Giulia Babini, Amedeo Ferlosio, Terenzio Cosio, Elena Campione, Ugo Moens, Marco Ciotti, Valeria Pietropaolo   +8 more
openaire   +5 more sources