Results 41 to 50 of about 2,161 (168)

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis

Frontiers in Microbiology, 2018
Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested as ...
Lisa M. Hillen, Dorit Rennspiess, Ernst-Jan Speel, Anke M. Haugg, Véronique Winnepenninckx, Axel zur Hausen   +5 more
doaj   +1 more source

Merkel Cell Polyomavirus (MCPyV) and Its Possible Role in Head and Neck Cancers. [PDF]

Biomedicines
Despite significant progress in its prevention, diagnosis, and treatment, head and neck cancer (HNC) remains a major global health issue due to its multifactorial pathogenesis. Indeed, HNCs have been found to be associated with different environmental and lifestyle factors, as well as with infection with oncogenic viruses.
Passerini S, Messina S, Moens U, Pietropaolo V.   +3 more
europepmc   +4 more sources

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Evaluation of Merkel Cell Polyomavirus DNA in Tissue Samples from Italian Patients with Diagnosis of MCC

Viruses, 2021
Because the incidence of Merkel cell carcinoma (MCC) has increased significantly during the last 10 years and it is recognized that Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation represent two different etiological inputs sharing ...
Carla Prezioso, Raffaella Carletti, Francisco Obregon, Francesca Piacentini, Anna Maria Manicone, Giuseppe Soda, Ugo Moens, Cira Di Gioia, Valeria Pietropaolo   +8 more
doaj   +1 more source

A Snapshot of the UK Blood Donor Plasma Virome: A Retrospective Cross‐Sectional Cohort Study

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Estimates of population prevalence and genetic diversity of bloodborne viruses in healthy humans are essential to support population‐scale monitoring for transfusion transmission risk. In the UK and globally, blood donations are routinely screened for a limited number of high‐consequence pathogens, but the full composition of the plasma virome
Kai Kean, Richard M. Mayne, Kaitlin Reid, Shannah Secret, Belinda K. Singleton, Rebecca Rockett, Piya Rajendra, Heli Harvala, Judith Breuer, M. Azim Ansari, Katrina Lythgoe, Peter Simmonds, Tanya Golubchik   +12 more
wiley   +1 more source

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.

PLoS Pathogens, 2021
Circular RNAs (circRNAs) are a conserved class of RNAs with diverse functions, including serving as messenger RNAs that are translated into peptides. Here we describe circular RNAs generated by human polyomaviruses (HPyVs), some of which encode variants ...
Rong Yang, Eunice E Lee, Jiwoong Kim, Joon H Choi, Elysha Kolitz, Yating Chen, Clair Crewe, Nicholas J H Salisbury, Philipp E Scherer, Clay Cockerell, Taylor R Smith, Leslie Rosen, Louisa Verlinden, Denise A Galloway, Christopher B Buck, Mariet C Feltkamp, Christopher S Sullivan, Richard C Wang   +17 more
doaj   +1 more source

Molecular and Phylogenetic Characterization of HTLV‐1 Infection in Patients With Hematological Malignancies in the State of Pará, Northern Brazil

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Human T‐lymphotropic viruses 1 and 2 (HTLV‐1 and HTLV‐2) were first isolated from patients with hematological malignancies. This study was the first to investigate the frequency of HTLV‐1 and its molecular diversity among patients with hematolymphoid cancers who were treated at a leading reference hospital in Pará, northern Brazil.
Gabriel dos Santos Pereira Neto, Ana Vilhena Alves, Bruno José Sarmento Botelho, Andrio Silva da Silva, Debora Monteiro Carneiro, Rommel Mario Rodriguez Burbano, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Izaura Maria Vieira Cayres Vallinoto   +8 more
wiley   +1 more source

Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma.

PLoS Pathogens, 2010
Merkel Cell Polyomavirus (MCPyV) is associated with Merkel Cell carcinoma (MCC), a rare, aggressive skin cancer with neuroendocrine features. The causal role of MCPyV is highly suggested by monoclonal integration of its genome and expression of the viral
Hélène C Laude, Barbara Jonchère, Eve Maubec, Agnès Carlotti, Eduardo Marinho, Benoit Couturaud, Martine Peter, Xavier Sastre-Garau, Marie-Françoise Avril, Nicolas Dupin, Flore Rozenberg   +10 more
doaj   +1 more source

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment.

PLoS ONE, 2020
AimsMerkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection.
María-Dolores Mendoza, Carlos Santonja, Carmen Gonzalez-Vela, Angel Concha, Nicolás Iglesias Pena, Eva-Maria Andrés-Esteban, Jose Pedro Vaque, Laura Cereceda, Raquel Pajares, H Kutzner, Luis Requena, Miguel A Piris   +11 more
doaj   +1 more source