Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel cell carcinoma [PDF]
Oncotarget, 2022 ABSTRACT Background Merkel cell carcinoma (MCC) is an aggressive skin cancer, related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. Immune checkpoint inhibitors provide sustained benefit in about half of MCC patients with advanced disease.
Muralidharan, Sujatha +3 more
openaire +2 more sources
Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer
Scientific Reports, 2021 Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC ...
Monir Ghanghareh +8 more
doaj +1 more source
MCPyV LT and 57kT bind Fbw7α independently of its WD40 domain and MCPyV LT S239.
, 2019 (A, B) MCPyV LT was pulled-down with XT10 from whole cell lysates of 293A cells transfected with individual or combinations of full-length MCPyV LT S239A (5μg), MCPyV LT-t (10.5μg), MCPyV 57kT (5μg), Fbw7 (4.5μg), ΔFbox (3μg), or R505L (3μg), and ...
Kristine N. Dye (6270047) +4 more
core +1 more source
Viruses, 2022 Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR techniques using formalin-fixed, paraffin-embedded (FFPE) tissues. The aim of this
Martina Barchitta +9 more
doaj +1 more source
Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung. [PDF]
PLoS ONE, 2009 BACKGROUND: A new virus called the Merkel Cell Polyomavirus (MCPyV) has recently been found in Merkel Cell Carcinoma (MCC). MCC is a rare aggressive small cell neuroendocrine carcinoma primarily derived from the skin, morphologically indistinguishable ...
Charlotte T A H Wetzels +5 more
doaj +1 more source
MCPyV genome sequence coverage versus MCPyV viral load in the six samples.
, 2012 Genome coverage is expressed as number of reads per nucleotide and viral load is in genome copies per ng of whole DNA. Coefficient of correlation is: R2 = 0.894; and best fit regression equation is: [MCPyV viral load] = 4.1 [MCPyV coverage]- 28,850.
Charles Hebert (157006) +11 more
core +1 more source
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
Emerging Infectious Diseases, 2010 To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 ...
Sonia Toracchio +6 more
doaj +1 more source
Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]
PLoS Pathogens, 2016 Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios +9 more
doaj +1 more source
Molecular mechanisms regulating the NCRR-driven transcriptional program of MCPyV.
, 2023 p300/CBP upregulate MCPyV gene expression primarily through acetylation of the p65 subunit of NF-κB, which binds directly to kB site(s) on the NCRR. p300/CBP may also acetylate the histones associated with the viral NCRR to stimulate MCPyV transcription.
Jianxin You (121729) +2 more
core +1 more source
Heterogeneous MAL3-101 sensitivity of MCPyV-positive and MCPyV-negative tumor cell lines.
, 2014 Cell lines were seeded with 10000 cells in 96-well plates and incubated for 24 h before they were treated for 72 h with the indicated concentrations of MAL3-101. Cell viability was determined by the trypan blue exclusion assay (A, B).
Peter Wipf (134666) +6 more
core +1 more source