Results 31 to 40 of about 3,161 (168)

Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer

Scientific Reports, 2021
Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC ...
Monir Ghanghareh, Jalal Mosayebi Amroabadi, Seyed Mohammad Tavangar, Shiva Irani, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh   +8 more
doaj   +1 more source

Depicting CREB-Dependent Transcriptome in MCPyV+ and MCPyV- Merkel Cell Carcinoma Cells

, 2021
Merkel Cell Carcinoma (MCC) is a highly malignant neuroendocrine tumor with an increasing incidence and the highest mortality rate amongst skin cancers (30%). They are usually diagnosed at advanced stages and still lack precise markers for diagnosis. MCC
Basdas, Rumeysa
core  

Comparison of Quantitative Real-Time PCR and Digital PCR to Detect the Polyomavirus in Merkel Cell Carcinoma

Viruses, 2022
Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR techniques using formalin-fixed, paraffin-embedded (FFPE) tissues. The aim of this
Martina Barchitta, Andrea Maugeri, Elisabetta Campisi, Roberta Magnano San Lio, Giuliana Favara, Hector Jose Soto Parra, Lucia Salvatorelli, Gaetano Magro, Guido Basile, Antonella Agodi   +9 more
doaj   +1 more source

MCPyV LT and 57kT bind Fbw7α independently of its WD40 domain and MCPyV LT S239.

, 2019
(A, B) MCPyV LT was pulled-down with XT10 from whole cell lysates of 293A cells transfected with individual or combinations of full-length MCPyV LT S239A (5μg), MCPyV LT-t (10.5μg), MCPyV 57kT (5μg), Fbw7 (4.5μg), ΔFbox (3μg), or R505L (3μg), and ...
Kristine N. Dye (6270047), Denise A. Galloway (153118), Markus Welcker (49712), Bruce E. Clurman (49715), Ann Roman (6270050)   +4 more
core   +1 more source

Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC) [PDF]

, 2023
Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed
Terenzio Cosio, Cosio, T, Valeria Pietropaolo, Ferlosio, A, Prezioso, C, Ferlosio, Amedeo, Moens, U, Pietropaolo, V, Pietropaolo, Valeria, Babini, G, Ciotti, Marco, Cosio, Terenzio, Elena Campione, Carla Prezioso, Sara Passerini, Moens, Ugo, Ciotti, M, Passerini, Sara, Babini, Giulia, Marco Ciotti, Giulia Babini, Ugo Moens, Passerini, S, Campione, Elena, Campione, E, Prezioso, Carla, Amedeo Ferlosio   +26 more
core   +1 more source

Heterogeneous MAL3-101 sensitivity of MCPyV-positive and MCPyV-negative tumor cell lines.

, 2014
Cell lines were seeded with 10000 cells in 96-well plates and incubated for 24 h before they were treated for 72 h with the indicated concentrations of MAL3-101. Cell viability was determined by the trypan blue exclusion assay (A, B).
Peter Wipf (134666), David Schrama (273819), Christian Adam (545902), Anne Baeurle (332558), Jeffrey L. Brodsky (351261), Roland Houben (96277), Jürgen Christian Becker (545903)   +6 more
core   +1 more source

MCPyV genome sequence coverage versus MCPyV viral load in the six samples.

, 2012
Genome coverage is expressed as number of reads per nucleotide and viral load is in genome copies per ng of whole DNA. Coefficient of correlation is: R2 = 0.894; and best fit regression equation is: [MCPyV viral load]  = 4.1 [MCPyV coverage]- 28,850.
Charles Hebert (157006), Valérie Caro (157050), Virginie Sauvage (157001), Meriadeg Ar Gouilh (157022), Olivier Dereure (157011), Michel Segondy (81333), Jean-Claude Manuguerra (157041), Marc Eloit (157053), Vincent Foulongne (156996), Kevin Pariente (157026), Justine Cheval (157016), Ana Burguière (157034)   +11 more
core   +1 more source

Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada

Emerging Infectious Diseases, 2010
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 ...
Sonia Toracchio, Annette Foyle, Vojtech Sroller, Jon A. Reed, Jun Wu, Claudia A. Kozinetz, Janet S. Butel   +6 more
doaj   +1 more source

Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung. [PDF]

PLoS ONE, 2009
BACKGROUND: A new virus called the Merkel Cell Polyomavirus (MCPyV) has recently been found in Merkel Cell Carcinoma (MCC). MCC is a rare aggressive small cell neuroendocrine carcinoma primarily derived from the skin, morphologically indistinguishable ...
Charlotte T A H Wetzels, Jolanda G M Hoefnagel, Judith M J E Bakkers, Henry B P M Dijkman, Willeke A M Blokx, Willem J G Melchers   +5 more
doaj   +1 more source

MCPyV DNA copy number.

, 2013
Relative quantification by QPCR of MCPyV DNA copies in eleven non irradiated skin samples from patient P18; normalization with GAPDH gene. Comparable results have been obtained with irradiated skin samples (data not shown).
Sébastien Corre (62241), Na Guo (198794), Alain Fautrel (209374), Laurent Misery (363611), Nicolas Mouchet (186275), Henri Adamski (248466), Eric Watier (248477), Ariane Mogha (149686), Marie-Dominique Galibert (62246)   +8 more
core   +1 more source