Results 31 to 40 of about 2,161 (168)

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]

PLoS Pathogens, 2012
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu, Holger Hengel, Bärbel S Blaum, Rachel M Schowalter, Dennis Macejak, Michel Gilbert, Warren W Wakarchuk, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Niklas Arnberg, Robert L Garcea, Thomas Peters, Christopher B Buck, Thilo Stehle   +14 more
doaj   +1 more source

Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions

Anais Brasileiros de Dermatologia, 2023
Human Polyomaviruses such as MCPyV and HPyV6 are frequently found as part of healthy skin microbiota and have been associated with Merkel cell carcinoma (MCC), pruritic and dyskeratotic dermatoses, respectively. Their presence in other types of skin conditions varies greatly depending on lesion type and population.To analyse comparatively the presence ...
Marianna T. Venceslau, Gabriella R.M. da Costa, Maria Angelica A.M. Guimarães, Rafael B. Varella, Flavio B. Luz   +4 more
openaire   +3 more sources

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

Thoracic Cancer, 2019
Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic ...
Emil Chteinberg, Faisal Klufah, Dorit Rennspiess, Mick F. Mannheims, Myrurgia A. Abdul‐Hamid, Mario Losen, Marlies Keijzers, Marc H. De Baets, Anna Kordelia Kurz, Axel zur Hausen   +9 more
doaj   +1 more source

Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel cell carcinoma [PDF]

Oncotarget, 2022
ABSTRACT Background Merkel cell carcinoma (MCC) is an aggressive skin cancer, related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. Immune checkpoint inhibitors provide sustained benefit in about half of MCC patients with advanced disease.
Muralidharan, Sujatha, Kervarrec, Thibault, Weiss, Glen J., Samimi, Mahtab   +3 more
openaire   +2 more sources

Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer

Scientific Reports, 2021
Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC ...
Monir Ghanghareh, Jalal Mosayebi Amroabadi, Seyed Mohammad Tavangar, Shiva Irani, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh   +8 more
doaj   +1 more source

Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC)

Pathogens, 2023
Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed on primary tumors and regional lymph nodes from two MCC patients: one metastatic and one non ...
Sara Passerini, Carla Prezioso, Giulia Babini, Amedeo Ferlosio, Terenzio Cosio, Elena Campione, Ugo Moens, Marco Ciotti, Valeria Pietropaolo   +8 more
openaire   +5 more sources

Comparison of Quantitative Real-Time PCR and Digital PCR to Detect the Polyomavirus in Merkel Cell Carcinoma

Viruses, 2022
Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR techniques using formalin-fixed, paraffin-embedded (FFPE) tissues. The aim of this
Martina Barchitta, Andrea Maugeri, Elisabetta Campisi, Roberta Magnano San Lio, Giuliana Favara, Hector Jose Soto Parra, Lucia Salvatorelli, Gaetano Magro, Guido Basile, Antonella Agodi   +9 more
doaj   +1 more source

Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung. [PDF]

PLoS ONE, 2009
BACKGROUND: A new virus called the Merkel Cell Polyomavirus (MCPyV) has recently been found in Merkel Cell Carcinoma (MCC). MCC is a rare aggressive small cell neuroendocrine carcinoma primarily derived from the skin, morphologically indistinguishable ...
Charlotte T A H Wetzels, Jolanda G M Hoefnagel, Judith M J E Bakkers, Henry B P M Dijkman, Willeke A M Blokx, Willem J G Melchers   +5 more
doaj   +1 more source

Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada

Emerging Infectious Diseases, 2010
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 ...
Sonia Toracchio, Annette Foyle, Vojtech Sroller, Jon A. Reed, Jun Wu, Claudia A. Kozinetz, Janet S. Butel   +6 more
doaj   +1 more source

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]

PLoS Pathogens, 2016
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio   +9 more
doaj   +1 more source