Results 31 to 40 of about 3,812 (207)
mBio, 2020 Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes
Svenja Siebels +8 more
doaj +1 more source
PLoS Pathogens, 2022 Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC).
Megan E Spurgeon +5 more
doaj +1 more source
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. [PDF]
, 2014 International audienceBACKGROUND: Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype.
A Kanik +38 more
core +4 more sources
CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors [PDF]
, 2021 ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCPyV) T antigen gene expression, post integration (∼80% cases), or by UV mediated DNA damage. Viral-positive Merkel tumors are not only caused by but also oncogenically addicted to tumor antigen ...
Reety Arora +2 more
openaire +1 more source
The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions [PDF]
, 2018 Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic ...
Andrew P. South +12 more
core +6 more sources
Viruses, 2020 Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCPyV ...
Reety Arora +3 more
doaj +1 more source
Detection and quantification of classic and emerging viruses by skimmed-milk flocculation and PCR in river water from two geographical areas [PDF]
, 2013 Molecular techniques and virus concentration methods have shown that previously unknown viruses are shed by humans and animals, and may be transmitted by sewage-contaminated water.
Bofill Mas, S. +7 more
core +1 more source
Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions
Anais Brasileiros de Dermatologia, 2023 Human Polyomaviruses such as MCPyV and HPyV6 are frequently found as part of healthy skin microbiota and have been associated with Merkel cell carcinoma (MCC), pruritic and dyskeratotic dermatoses, respectively. Their presence in other types of skin conditions varies greatly depending on lesion type and population.To analyse comparatively the presence ...
Marianna T. Venceslau +4 more
openaire +3 more sources
Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]
PLoS Pathogens, 2012 The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu +14 more
doaj +1 more source
Viruses, 2019 Background: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial, and it is still unclear in patients with cystic fibrosis (CF).
Carla Prezioso +8 more
doaj +1 more source