Results 31 to 40 of about 2,946 (205)
Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges. [PDF]
Head NeckABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Holley HA +6 more
europepmc +2 more sources
CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors [PDF]
, 2021 ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCPyV) T antigen gene expression, post integration (∼80% cases), or by UV mediated DNA damage. Viral-positive Merkel tumors are not only caused by but also oncogenically addicted to tumor antigen ...
Reety Arora +2 more
openaire +1 more source
PLoS Pathogens, 2022 Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC).
Megan E Spurgeon +5 more
doaj +1 more source
mBio, 2020 Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes
Svenja Siebels +8 more
doaj +1 more source
Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer. [PDF]
Mol OncolThis study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Jeremian R +10 more
europepmc +2 more sources
Viruses, 2020 Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCPyV ...
Reety Arora +3 more
doaj +1 more source
Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]
PLoS Pathogens, 2012 The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu +14 more
doaj +1 more source
Viruses, 2019 Background: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial, and it is still unclear in patients with cystic fibrosis (CF).
Carla Prezioso +8 more
doaj +1 more source
Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors
Thoracic Cancer, 2019 Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic ...
Emil Chteinberg +9 more
doaj +1 more source
Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions
Anais Brasileiros de Dermatologia, 2023 Human Polyomaviruses such as MCPyV and HPyV6 are frequently found as part of healthy skin microbiota and have been associated with Merkel cell carcinoma (MCC), pruritic and dyskeratotic dermatoses, respectively. Their presence in other types of skin conditions varies greatly depending on lesion type and population.To analyse comparatively the presence ...
Marianna T. Venceslau +4 more
openaire +3 more sources