Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC
Viruses, 2022 Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke +2 more
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Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles [PDF]
Cancers, 2021 Background: Merkel cell carcinomas of unknown primary (MCC-UPs) are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent primary tumors of lymph nodes or metastatic cutaneous primaries.
Piotr Donizy +11 more
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Blood, 2011 In this issue of Blood, Pancaldi et al report on the latent presence of large T antigen (LTag) sequences of the Merkel cell polyomavirus (MCPyV) in buffy coats of healthy individuals ...
zur Hausen A, TOGNON, Mauro
core +4 more sources
Prevalence of Merkel Cell Polyomavirus (MCPyV) in the Oral Cavity Biopsies in Northern Iran [PDF]
Asian Pacific Journal of Cancer Prevention, 2021 Infection with human tumor viruses is one of the hypothesized causes of cancer. The current investigation aimed to explore the presence and quantitative analysis of a new human tumor virus, Merkel cell polyomavirus (MCPyV) in tissue samples of 114 patients with oral cavity lesions including oral squamous cell carcinoma (OSCC), oral lichen planus (OLP),
Hasani Estalkhi, Mina +6 more
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Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC) [PDF]
Pathogens, 2023 Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed on primary tumors and regional lymph nodes from two MCC patients: one metastatic and one non ...
Sara Passerini +8 more
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Depicting CREB-Dependent Transcriptome in MCPyV+ and MCPyV- Merkel Cell Carcinoma Cells
, 2021 Merkel Cell Carcinoma (MCC) is a highly malignant neuroendocrine tumor with an increasing incidence and the highest mortality rate amongst skin cancers (30%). They are usually diagnosed at advanced stages and still lack precise markers for diagnosis. MCC has two main etiologies: polyomavirus-positive (MCPyV+) and -negative (MCPyV-).
Basdas, Rumeysa
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Merkel Cell Polyomavirus (MCPyV) and Its Possible Role in Head and Neck Cancers. [PDF]
BiomedicinesDespite significant progress in its prevention, diagnosis, and treatment, head and neck cancer (HNC) remains a major global health issue due to its multifactorial pathogenesis. Indeed, HNCs have been found to be associated with different environmental and lifestyle factors, as well as with infection with oncogenic viruses.
Passerini S +3 more
europepmc +5 more sources
Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome. [PDF]
PLoS ONE, 2017 The aim of this study was to determine the prevalence of MCPyV in Merkel cell carcinoma (MCC) primaries versus lymph node metastasis and to evaluate possible prognostic factors.Samples of MCC primaries and lymph node metastases were stained ...
Georg Haymerle +9 more
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Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]
J Med VirolABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S +8 more
europepmc +2 more sources
Replikace polyomaviru Merkelových buněk (MCPyV) v lidských buněčných kulturách
, 2022 The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus classified as probably carcinogenic to humans and is the causal factor of a rare aggressive skin malignancy the Merkel cell carcinoma (MCC) in around 80% of cases. Nevertheless, in addition to skin the virus was detected in various body tissues. In spite of that an ideal in vitro model
Bučková, Alžbeta
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