Results 11 to 20 of about 3,161 (168)
Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC
Viruses, 2022 Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke +2 more
doaj +2 more sources
The role of MCPyV ST in Merkel cell carcinoma metastasis [PDF]
, 2017 Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity for metastasis via the dermal lymphatic system.
Nwogu, Nnenna Onyinyechi Uchechi
core +6 more sources
The Significance of cGAS-STING Signaling in Response to Oncogenic Viruses. [PDF]
Cell Biochem FunctABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Guo L, Li L, Wang F, Liu W, Zhang Y.
europepmc +2 more sources
Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]
J Med VirolABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S +8 more
europepmc +2 more sources
Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status. [PDF]
Int J CancerWhat's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Fagerstedt KW +6 more
europepmc +2 more sources
Frontiers in Oncology, 2022 The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial.
Wilson A. Wijaya +3 more
doaj +1 more source
Virology Journal, 2012 Background Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (
Imajoh Masayuki +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Merkel cell polyomavirus (MCPyV) is a small DNA tumor virus ubiquitous in humans. MCPyV establishes a clinically asymptomatic lifelong infection in healthy immunocompetent individuals.
Chiara Mazziotta +7 more
doaj +1 more source
, 2021 Background: Merkel cell carcinomas of unknown primary (MCC-UPs) are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent ...
Katarzyna Woznica +11 more
core +1 more source
Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors
Frontiers in Oncology, 2017 Merkel cell polyomavirus (MCPyV) has been detected in 80% of Merkel cell carcinomas (MCC). In the host, the MCPyV reservoir remains elusive. MCPyV DNA sequences were revealed in blood donor buffy coats.
Elisa Mazzoni +8 more
doaj +1 more source