Results 11 to 20 of about 3,812 (207)

Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC

Viruses, 2022
Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke, Paul F. Lambert, Megan E. Spurgeon   +2 more
doaj   +3 more sources

Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]

J Med Virol
ABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S, Mariotti D, Messina S, Mazzotta V, Matusali G, Antinori A, Pietropaolo V, Maggi F, Rosa L.   +8 more
europepmc   +2 more sources

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status. [PDF]

Int J Cancer
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Fagerstedt KW, Kilpinen S, Arola J, Sundqvist BZ, Böhling T, Andersson LC, Sihto H.   +6 more
europepmc   +2 more sources

RB1 inactivation in cutaneous carcinomas. [PDF]

Histopathology
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Liv T, Touzé A, Schrama D, Guyétant S, Samimi M, Tetzlaff MT, Wood BA, Harms PW, Kervarrec T.   +8 more
europepmc   +2 more sources

Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles [PDF]

Cancers, 2021
Background: Merkel cell carcinomas of unknown primary (MCC-UPs) are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent primary tumors of lymph nodes or metastatic cutaneous primaries.
Piotr Donizy, Joanna P. Wróblewska, Dora Dias-Santagata, Katarzyna Woznica, Przemyslaw Biecek, Mark C. Mochel, Cheng-Lin Wu, Janusz Kopczynski, Malgorzata Pieniazek, Janusz Ryś, Andrzej Marszalek, Mai P. Hoang   +11 more
openaire   +2 more sources

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj   +1 more source

Decreased IgG Antibody Response to Viral Protein Mimotopes of Oncogenic Merkel Cell Polyomavirus in Sera From Healthy Elderly Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV) is the main causative agent of Merkel cell carcinoma (MCC), a rare but aggressive skin tumor with a typical presentation age >60 years. MCPyV is ubiquitous in humans.
Chiara Mazziotta, Chiara Mazziotta, Carmen Lanzillotti, Carmen Lanzillotti, Marcello Govoni, Giulia Pellielo, Elisa Mazzoni, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +11 more
doaj   +1 more source

Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens [PDF]

Viruses, 2022
To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS).
Carla Prezioso, Gabriele Brazzini, Sara Passerini, Carlotta Di Fabio, Terenzio Cosio, Sergio Bernardini, Elena Campione, Ugo Moens, Valeria Pietropaolo, Marco Ciotti   +9 more
openaire   +7 more sources

Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China. [PDF]

PLoS ONE, 2014
BACKGROUND: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China ...
Chanyuan Zhang, Fangfang Liu, Zhonghu He, Qiuju Deng, Yaqi Pan, Ying Liu, Chaoting Zhang, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke   +13 more
doaj   +1 more source

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial.
Wilson A. Wijaya, Yu Liu, Yong Qing, Zhengyong Li   +3 more
doaj   +1 more source