Results 11 to 20 of about 2,161 (168)
Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC
Viruses, 2022 Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke +2 more
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Frontiers in Oncology, 2022 Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma (MCC), TLSs have only been examined in MCPyV-positive cases.
Motoki Nakamura +5 more
doaj +1 more source
T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. [PDF]
PLoS ONE, 2011 The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral ...
Arun Kumar +6 more
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Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles [PDF]
Cancers, 2021 Background: Merkel cell carcinomas of unknown primary (MCC-UPs) are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent primary tumors of lymph nodes or metastatic cutaneous primaries.
Piotr Donizy +11 more
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Frontiers in Immunology, 2021 Merkel cell polyomavirus (MCPyV) is the main causative agent of Merkel cell carcinoma (MCC), a rare but aggressive skin tumor with a typical presentation age >60 years. MCPyV is ubiquitous in humans.
Chiara Mazziotta +11 more
doaj +1 more source
Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens [PDF]
Viruses, 2022 To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS).
Carla Prezioso +9 more
openaire +7 more sources
Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China. [PDF]
PLoS ONE, 2014 BACKGROUND: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China ...
Chanyuan Zhang +13 more
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From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis
Frontiers in Microbiology, 2021 Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj +1 more source
Frontiers in Immunology, 2021 Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays for detecting
Chiara Mazziotta +12 more
doaj +1 more source
Frontiers in Oncology, 2022 The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial.
Wilson A. Wijaya +3 more
doaj +1 more source