Results 21 to 30 of about 3,812 (207)

Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays for detecting
Chiara Mazziotta, Carmen Lanzillotti, Elena Torreggiani, Lucia Oton-Gonzalez, Maria Rosa Iaquinta, Elisa Mazzoni, Pauline Gaboriaud, Antoine Touzé, Ettore Silvagni, Marcello Govoni, Fernanda Martini, Mauro Tognon, John Charles Rotondo   +12 more
doaj   +1 more source

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges. [PDF]

Head Neck
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Holley HA, Lyons M, O'Sullivan B, Shine N, Woods R, McArdle O, O'Neill JP.   +6 more
europepmc   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer. [PDF]

Mol Oncol
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Jeremian R, Sivachandran S, Galati M, Ramchatesingh B, Rijal H, Hanna J, Netchiporouk E, Chergui M, Redpath M, Abou Setah S, Litvinov IV.   +10 more
europepmc   +2 more sources

Prevalence of Merkel Cell Polyomavirus (MCPyV) in the Oral Cavity Biopsies in Northern Iran [PDF]

Asian Pacific Journal of Cancer Prevention, 2021
Infection with human tumor viruses is one of the hypothesized causes of cancer. The current investigation aimed to explore the presence and quantitative analysis of a new human tumor virus, Merkel cell polyomavirus (MCPyV) in tissue samples of 114 patients with oral cavity lesions including oral squamous cell carcinoma (OSCC), oral lichen planus (OLP),
Hasani Estalkhi, Mina, Seyed Majidi, Maryam, Sadeghi, Farzin, Chehrazi, Mohammad, Zebardast, Arghavan, Hasanzadeh, Ali, Yahyapour, Yousef   +6 more
openaire   +2 more sources

Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients

Virology Journal, 2012
Background Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (
Imajoh Masayuki, Hashida Yumiko, Nemoto Yuiko, Oguri Hiroyoshi, Maeda Nagamasa, Furihata Mutsuo, Fukaya Takao, Daibata Masanori   +7 more
doaj   +1 more source

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Oncotarget, 2015
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To define the genetic basis of MCCs, we performed exome sequencing of 49 MCCs. We show that MCPyV-negative MCCs have a high mutation burden (median of 1121 somatic single nucleotide ...
Goh, Gerald, Walradt, Trent, Markarov, Vladimir, Blom, Astrid, Riaz, Nadeem, Doumani, Ryan, Stafstrom, Krista, Moshiri, Ata, Yelistratova, Lola, Levinsohn, Jonathan, Chan, Timothy A., Nghiem, Paul, Lifton, Richard P., Choi, Jaehyuk   +13 more
openaire   +3 more sources

Significantly Low Levels of IgG Antibodies Against Oncogenic Merkel Cell Polyomavirus in Sera From Females Affected by Spontaneous Abortion

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA tumor virus ubiquitous in humans. MCPyV establishes a clinically asymptomatic lifelong infection in healthy immunocompetent individuals.
Chiara Mazziotta, Chiara Mazziotta, Giulia Pellielo, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +7 more
doaj   +1 more source

Production of recombinant VP1-derived virus-like particles from novel human polyomaviruses in yeast [PDF]

, 2015
Background: Eleven new human polyomaviruses (HPyVs) have been identified in the last decade. Serological studies show that these novel HPyVs sub-clinically infect humans at an early age.
Alma Gedvilaite, Danguole Ziogiene, Egle Mazeike, Jomante Stonyte, Kestutis Sasnauskas, Milda Norkiene   +5 more
core   +1 more source

Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors

Frontiers in Oncology, 2017
Merkel cell polyomavirus (MCPyV) has been detected in 80% of Merkel cell carcinomas (MCC). In the host, the MCPyV reservoir remains elusive. MCPyV DNA sequences were revealed in blood donor buffy coats.
Elisa Mazzoni, John C. Rotondo, Luisa Marracino, Rita Selvatici, Ilaria Bononi, Elena Torreggiani, Antoine Touzé, Fernanda Martini, Mauro G. Tognon   +8 more
doaj   +1 more source

Human polyomaviruses in children undergoing transplantation, United States, 2008-2010 [PDF]

, 2012
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known ...
Bauer, Irma, Canter, Charles, Hmiel, Paul, Holtz, Lori R, Lassa-Claxton, Sherry, Le, Binh-minh, Shenoy, Shalini, Shepherd, Ross, Siebrasse, Erica A, Sweet, Stuart, Turmelle, Yumirle, Wang, David   +11 more
core   +2 more sources