Results 21 to 30 of about 2,161 (168)

Prevalence of Merkel Cell Polyomavirus (MCPyV) in the Oral Cavity Biopsies in Northern Iran [PDF]

Asian Pacific Journal of Cancer Prevention, 2021
Infection with human tumor viruses is one of the hypothesized causes of cancer. The current investigation aimed to explore the presence and quantitative analysis of a new human tumor virus, Merkel cell polyomavirus (MCPyV) in tissue samples of 114 patients with oral cavity lesions including oral squamous cell carcinoma (OSCC), oral lichen planus (OLP),
Hasani Estalkhi, Mina, Seyed Majidi, Maryam, Sadeghi, Farzin, Chehrazi, Mohammad, Zebardast, Arghavan, Hasanzadeh, Ali, Yahyapour, Yousef   +6 more
openaire   +2 more sources

Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients

Virology Journal, 2012
Background Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (
Imajoh Masayuki, Hashida Yumiko, Nemoto Yuiko, Oguri Hiroyoshi, Maeda Nagamasa, Furihata Mutsuo, Fukaya Takao, Daibata Masanori   +7 more
doaj   +1 more source

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Oncotarget, 2015
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To define the genetic basis of MCCs, we performed exome sequencing of 49 MCCs. We show that MCPyV-negative MCCs have a high mutation burden (median of 1121 somatic single nucleotide ...
Goh, Gerald, Walradt, Trent, Markarov, Vladimir, Blom, Astrid, Riaz, Nadeem, Doumani, Ryan, Stafstrom, Krista, Moshiri, Ata, Yelistratova, Lola, Levinsohn, Jonathan, Chan, Timothy A., Nghiem, Paul, Lifton, Richard P., Choi, Jaehyuk   +13 more
openaire   +3 more sources

Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors

Frontiers in Oncology, 2017
Merkel cell polyomavirus (MCPyV) has been detected in 80% of Merkel cell carcinomas (MCC). In the host, the MCPyV reservoir remains elusive. MCPyV DNA sequences were revealed in blood donor buffy coats.
Elisa Mazzoni, John C. Rotondo, Luisa Marracino, Rita Selvatici, Ilaria Bononi, Elena Torreggiani, Antoine Touzé, Fernanda Martini, Mauro G. Tognon   +8 more
doaj   +1 more source

Significantly Low Levels of IgG Antibodies Against Oncogenic Merkel Cell Polyomavirus in Sera From Females Affected by Spontaneous Abortion

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA tumor virus ubiquitous in humans. MCPyV establishes a clinically asymptomatic lifelong infection in healthy immunocompetent individuals.
Chiara Mazziotta, Chiara Mazziotta, Giulia Pellielo, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +7 more
doaj   +1 more source

CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors [PDF]

, 2021
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCPyV) T antigen gene expression, post integration (∼80% cases), or by UV mediated DNA damage. Viral-positive Merkel tumors are not only caused by but also oncogenically addicted to tumor antigen ...
Reety Arora, Komal Gupta, Anjali Vijaykumar   +2 more
openaire   +1 more source

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

PLoS Pathogens, 2022
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC).
Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert   +5 more
doaj   +1 more source

Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner

mBio, 2020
Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes
Svenja Siebels, Manja Czech-Sioli, Michael Spohn, Claudia Schmidt, Juliane Theiss, Daniela Indenbirken, Thomas Günther, Adam Grundhoff, Nicole Fischer   +8 more
doaj   +1 more source

Merkel Cell Polyomavirus DNA Detection in Respiratory Samples: Study of a Cohort of Patients Affected by Cystic Fibrosis

Viruses, 2019
Background: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial, and it is still unclear in patients with cystic fibrosis (CF).
Carla Prezioso, Federica Maria Di Lella, Donatella Maria Rodio, Camilla Bitossi, Maria Trancassini, Annamaria Mele, Corrado de Vito, Guido Antonelli, Valeria Pietropaolo   +8 more
doaj   +1 more source

Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Integration Sites and Involvement of the KMT2D Tumor Suppressor Gene

Viruses, 2020
Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCPyV ...
Reety Arora, Jae Eun Choi, Paul W. Harms, Pratik Chandrani   +3 more
doaj   +1 more source