Results 21 to 30 of about 3,161 (168)

Inhibition of the ATR-CHK1 signaling pathway sensitizes MCPyV-positive Merkel cell carcinoma to gemcitabine. [PDF]

BMC Cancer
Merkel cell carcinoma (MCC) is the primary cutaneous neuroendocrine carcinoma with a mortality rate higher than that of melanoma and other common skin cancers.
Proctor EV, Elsawa SF, Walker SR, Cheng J.   +3 more
europepmc   +2 more sources

Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner

mBio, 2020
Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes
Svenja Siebels, Manja Czech-Sioli, Michael Spohn, Claudia Schmidt, Juliane Theiss, Daniela Indenbirken, Thomas Günther, Adam Grundhoff, Nicole Fischer   +8 more
doaj   +1 more source

A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infection. [PDF]

Journal of Virology
Jianxin You
exaly   +2 more sources

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

PLoS Pathogens, 2022
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC).
Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert   +5 more
doaj   +1 more source

Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study. [PDF]

J Med Virol
ABSTRACT This multicentre study investigated the utility of next‐generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/mL). 23 HBV DNA‐positive plasma samples of genotypes A‐E and one HBV‐negative control sample were assayed blindly via 9 established NGS methods from 6 ...
Fu MX, Perdomo MF, Lumley SF, Ringlander J, Kean K, Reid K, Mayne R, Montaguth OET, Forrest L, Buddle S, Botha JC, Stenbäck JB, Dickson Z, Kent C, Chai H, Byott M, Hannolainen L, Secret S, Airey G, Hedman K, Andersson MI, Ansari MA, Nastouli E, Breuer J, Matthews PC, Golubchik T, Irving WL, Simmonds P, Harvala H.   +28 more
europepmc   +2 more sources

Merkel Cell Polyomavirus DNA Detection in Respiratory Samples: Study of a Cohort of Patients Affected by Cystic Fibrosis

Viruses, 2019
Background: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial, and it is still unclear in patients with cystic fibrosis (CF).
Carla Prezioso, Federica Maria Di Lella, Donatella Maria Rodio, Camilla Bitossi, Maria Trancassini, Annamaria Mele, Corrado de Vito, Guido Antonelli, Valeria Pietropaolo   +8 more
doaj   +1 more source

Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Integration Sites and Involvement of the KMT2D Tumor Suppressor Gene

Viruses, 2020
Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCPyV ...
Reety Arora, Jae Eun Choi, Paul W. Harms, Pratik Chandrani   +3 more
doaj   +1 more source

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]

PLoS Pathogens, 2012
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu, Holger Hengel, Bärbel S Blaum, Rachel M Schowalter, Dennis Macejak, Michel Gilbert, Warren W Wakarchuk, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Niklas Arnberg, Robert L Garcea, Thomas Peters, Christopher B Buck, Thilo Stehle   +14 more
doaj   +1 more source

RB1 inactivation in cutaneous carcinomas. [PDF]

Histopathology
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Liv T, Touzé A, Schrama D, Guyétant S, Samimi M, Tetzlaff MT, Wood BA, Harms PW, Kervarrec T.   +8 more
europepmc   +2 more sources

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

Thoracic Cancer, 2019
Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic ...
Emil Chteinberg, Faisal Klufah, Dorit Rennspiess, Mick F. Mannheims, Myrurgia A. Abdul‐Hamid, Mario Losen, Marlies Keijzers, Marc H. De Baets, Anna Kordelia Kurz, Axel zur Hausen   +9 more
doaj   +1 more source