Results 1 to 10 of about 2,161 (168)

A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infection [PDF]

Journal of Virology
ABSTRACT Merkel cell polyomavirus (MCPyV) is an oncogenic human polyomavirus that latently infects most adults. Although the causative link between MCPyV and Merkel cell carcinoma is well established, the molecular mechanisms that govern viral latency and prevent oncogenic progression remain ...
Jianxin You
exaly   +4 more sources

Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]

J Med Virol
ABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S, Mariotti D, Messina S, Mazzotta V, Matusali G, Antinori A, Pietropaolo V, Maggi F, Rosa L.   +8 more
europepmc   +2 more sources

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status. [PDF]

Int J Cancer
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Fagerstedt KW, Kilpinen S, Arola J, Sundqvist BZ, Böhling T, Andersson LC, Sihto H.   +6 more
europepmc   +2 more sources

Merkel cell polyomavirus exploits extracellular vesicles for skin infection and host immune evasion through activated Wnt signaling. [PDF]

PLoS Pathogens
Research on small DNA tumor viruses has been limited by the lack of advanced virus culture systems that support robust viral infection. Thus, studies involving Merkel cell polyomavirus (MCPyV), a human oncogenic polyomavirus, primarily rely on model ...
Alexander M Pham, Luz E Ortiz, Han Chen, Neil Christensen, Hyun Jin Kwun   +4 more
doaj   +2 more sources

Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]

Scientific Reports
Merkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema, Charlotte van Gorp, Amanda Macamo, Axel zur Hausen, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Jos L. V. Broers   +6 more
doaj   +2 more sources

RB1 inactivation in cutaneous carcinomas. [PDF]

Histopathology
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Liv T, Touzé A, Schrama D, Guyétant S, Samimi M, Tetzlaff MT, Wood BA, Harms PW, Kervarrec T.   +8 more
europepmc   +2 more sources

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges. [PDF]

Head Neck
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Holley HA, Lyons M, O'Sullivan B, Shine N, Woods R, McArdle O, O'Neill JP.   +6 more
europepmc   +2 more sources

Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy [PDF]

Frontiers in Oncology
Lung cancer (LC) has been recognized as the leading cause of cancer mortality on a global scale. Although tobacco smoking is predominantly associated with LC (~85%), approximately 15-25% of lung cancers occur in non-smokers.
Changlong Zhou, Liang Lu, Maohong Hu, Tetsuro Suzuki, Xianfeng Zhou   +4 more
doaj   +2 more sources

Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study [PDF]

Discover Oncology
Merkel Cell Polyomavirus (MCPyV) is recognized as the major aetiological agent of Merkel Cell Carcinoma (MCC), an aggressive skin tumor. MCPyV-mediated oncogenesis is strictly dependent on viral integration and the expression of a truncated form of the ...
Sara Passerini, Matteo Fracella, Amedeo Ferlosio, Ugo Moens, Carolina Scagnolari, Guido Antonelli, Marco Ciotti, Valeria Pietropaolo   +7 more
doaj   +2 more sources

Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential.

PLoS Pathogens, 2023
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F Yang, Wei Liu, Jianxin You
doaj   +3 more sources