A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infection [PDF]
Journal of VirologyABSTRACT Merkel cell polyomavirus (MCPyV) is an oncogenic human polyomavirus that latently infects most adults. Although the causative link between MCPyV and Merkel cell carcinoma is well established, the molecular mechanisms that govern viral latency and prevent oncogenic progression remain ...
Xiaomei Li, Jianxin You
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Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]
Scientific ReportsMerkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema +6 more
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Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy [PDF]
Frontiers in OncologyLung cancer (LC) has been recognized as the leading cause of cancer mortality on a global scale. Although tobacco smoking is predominantly associated with LC (~85%), approximately 15-25% of lung cancers occur in non-smokers.
Changlong Zhou +4 more
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Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study [PDF]
Discover OncologyMerkel Cell Polyomavirus (MCPyV) is recognized as the major aetiological agent of Merkel Cell Carcinoma (MCC), an aggressive skin tumor. MCPyV-mediated oncogenesis is strictly dependent on viral integration and the expression of a truncated form of the ...
Sara Passerini +7 more
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PLoS Pathogens, 2023 Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F Yang, Wei Liu, Jianxin You
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Frontiers in Oncology, 2022 Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma (MCC), TLSs have only been examined in MCPyV-positive cases.
Motoki Nakamura +5 more
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T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. [PDF]
PLoS ONE, 2011 The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral ...
Arun Kumar +6 more
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Frontiers in Immunology, 2021 Merkel cell polyomavirus (MCPyV) is the main causative agent of Merkel cell carcinoma (MCC), a rare but aggressive skin tumor with a typical presentation age >60 years. MCPyV is ubiquitous in humans.
Chiara Mazziotta +11 more
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Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China. [PDF]
PLoS ONE, 2014 BACKGROUND: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China ...
Chanyuan Zhang +13 more
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From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis
Frontiers in Microbiology, 2021 Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
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