T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. [PDF]
PLoS ONE, 2011 The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral ...
Arun Kumar +6 more
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Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study [PDF]
Discover OncologyMerkel Cell Polyomavirus (MCPyV) is recognized as the major aetiological agent of Merkel Cell Carcinoma (MCC), an aggressive skin tumor. MCPyV-mediated oncogenesis is strictly dependent on viral integration and the expression of a truncated form of the ...
Sara Passerini +7 more
doaj +4 more sources
Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]
Scientific ReportsMerkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema +6 more
doaj +2 more sources
Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]
PLoS Pathogens, 2016 Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios +9 more
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The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment. [PDF]
PLoS ONE, 2020 AimsMerkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection.
María-Dolores Mendoza +11 more
doaj +3 more sources
Evaluation of Merkel Cell Polyomavirus DNA in Tissue Samples from Italian Patients with Diagnosis of MCC [PDF]
Viruses, 2021 Because the incidence of Merkel cell carcinoma (MCC) has increased significantly during the last 10 years and it is recognized that Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation represent two different etiological inputs sharing ...
Carla Prezioso +8 more
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Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy [PDF]
Frontiers in OncologyLung cancer (LC) has been recognized as the leading cause of cancer mortality on a global scale. Although tobacco smoking is predominantly associated with LC (~85%), approximately 15-25% of lung cancers occur in non-smokers.
Changlong Zhou +4 more
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PLoS Pathogens, 2023 Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F Yang, Wei Liu, Jianxin You
doaj +3 more sources
A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infection [PDF]
Journal of VirologyJianxin You
exaly +2 more sources
Frontiers in Oncology, 2022 Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma (MCC), TLSs have only been examined in MCPyV-positive cases.
Motoki Nakamura +5 more
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