Results 1 to 10 of about 3,161 (168)

Merkel cell polyomavirus exploits extracellular vesicles for skin infection and host immune evasion through activated Wnt signaling. [PDF]

PLoS Pathogens
Research on small DNA tumor viruses has been limited by the lack of advanced virus culture systems that support robust viral infection. Thus, studies involving Merkel cell polyomavirus (MCPyV), a human oncogenic polyomavirus, primarily rely on model ...
Alexander M Pham, Luz E Ortiz, Han Chen, Neil Christensen, Hyun Jin Kwun   +4 more
doaj   +2 more sources

Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]

Scientific Reports
Merkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema, Charlotte van Gorp, Amanda Macamo, Axel zur Hausen, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Jos L. V. Broers   +6 more
doaj   +2 more sources

Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy [PDF]

Frontiers in Oncology
Lung cancer (LC) has been recognized as the leading cause of cancer mortality on a global scale. Although tobacco smoking is predominantly associated with LC (~85%), approximately 15-25% of lung cancers occur in non-smokers.
Changlong Zhou, Liang Lu, Maohong Hu, Tetsuro Suzuki, Xianfeng Zhou   +4 more
doaj   +2 more sources

Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential

PLoS Pathogens, 2023
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F. Yang, Wei Liu, Jianxin You
doaj   +3 more sources

Tertiary Lymphoid Structures and Chemokine Landscape in Virus-Positive and Virus-Negative Merkel Cell Carcinoma

Frontiers in Oncology, 2022
Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma (MCC), TLSs have only been examined in MCPyV-positive cases.
Motoki Nakamura, Tetsuya Magara, Shinji Kano, Akihiro Matsubara, Hiroshi Kato, Akimichi Morita   +5 more
doaj   +1 more source

T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. [PDF]

PLoS ONE, 2011
The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral ...
Arun Kumar, Tingting Chen, Sari Pakkanen, Anu Kantele, Maria Söderlund-Venermo, Klaus Hedman, Rauli Franssila   +6 more
doaj   +1 more source

Decreased IgG Antibody Response to Viral Protein Mimotopes of Oncogenic Merkel Cell Polyomavirus in Sera From Healthy Elderly Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV) is the main causative agent of Merkel cell carcinoma (MCC), a rare but aggressive skin tumor with a typical presentation age >60 years. MCPyV is ubiquitous in humans.
Chiara Mazziotta, Chiara Mazziotta, Carmen Lanzillotti, Carmen Lanzillotti, Marcello Govoni, Giulia Pellielo, Elisa Mazzoni, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +11 more
doaj   +1 more source

Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China. [PDF]

PLoS ONE, 2014
BACKGROUND: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China ...
Chanyuan Zhang, Fangfang Liu, Zhonghu He, Qiuju Deng, Yaqi Pan, Ying Liu, Chaoting Zhang, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke   +13 more
doaj   +1 more source

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj   +1 more source

Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays for detecting
Chiara Mazziotta, Carmen Lanzillotti, Elena Torreggiani, Lucia Oton-Gonzalez, Maria Rosa Iaquinta, Elisa Mazzoni, Pauline Gaboriaud, Antoine Touzé, Ettore Silvagni, Marcello Govoni, Fernanda Martini, Mauro Tognon, John Charles Rotondo   +12 more
doaj   +1 more source