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Carcinome de Merkel : valeur pronostique et intérêt clinique de la sérologie contre MCPyV
Annales de Dermatologie et de Vénéréologie, 2014Introduction Le carcinome neuroendocrine primitif cutane ou carcinome de Merkel (CM), est un cancer cutane rare mais agressif, avec une mortalite de 46 %. Il n’existe pas de marqueurs biologiques pour le suivi des patients. 80 % des CM presentent l’integration clonale du polyomavirus des cellules de Merkel (MCPyV) et l’expression de l’oncoproteine ...
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Replikace polyomaviru Merkelových buněk (MCPyV) v lidských buněčných kulturách
2022The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus classified as probably carcinogenic to humans and is the causal factor of a rare aggressive skin malignancy the Merkel cell carcinoma (MCC) in around 80% of cases. Nevertheless, in addition to skin the virus was detected in various body tissues. In spite of that an ideal in vitro model
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Charakterizace imunitní odpovědi proti lidskému polyomaviru MCPyV.
2013Characterization of immune responses to human polyomavirus MCPyV There have been considerable increase in number of known human polyomaviruses in recent years; currently we register twelve of them. Presumably, majority of human polyomaviruses cause lifelong persistent infection. Primary infection is usually asymptomatic and is followed by appearance of
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Role T antigenů polyomaviru Merkelových buněk (MCPyV) v kancerogenezi
Merkel cell polyomavirus (MCPyV) is a virus with double-stranded DNA genome that mostly causes an asymptomatic primary infection, followed by the establishment of viral persistence, making this virus a part of normal skin microbiota. Under certain circumstances, mutations of the viral genome may occur, which are associated with its integration into theopenaire +1 more source

