Results 91 to 100 of about 57,512 (227)

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]

, 2017
The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin, Cox, Eric, Krammer, Florian, Mancera Gracia, José Carlos, Qiu, Yu, Sys, Lieve, Trus, Ivan, Van Reeth, Kristien, Versnaeyen, Han   +8 more
core   +2 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Tracking cholesterol/sphingomyelin-rich membrane domains with the ostreolysin A-mCherry protein.

PLoS ONE, 2014
Ostreolysin A (OlyA) is an ∼15-kDa protein that has been shown to bind selectively to membranes rich in cholesterol and sphingomyelin. In this study, we investigated whether OlyA fluorescently tagged at the C-terminal with mCherry (OlyA-mCherry) labels ...
Matej Skočaj, Nataša Resnik, Maja Grundner, Katja Ota, Nejc Rojko, Vesna Hodnik, Gregor Anderluh, Andrzej Sobota, Peter Maček, Peter Veranič, Kristina Sepčić   +10 more
doaj   +1 more source

Polarized secretion of apoA-I and apoA-II by transfected MDCK cells.

Journal of Lipid Research, 1995
Apolipoproteins (apo) are secreted preferentially from the basolateral surface of hepatocytes and enterocytes. The polarized secretion of proteins is either mediated by a protein-dependent sorting signal or by a cell-dependent default pathway.
A T Remaley, J M Hoeg
doaj   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Surfactants as microbicides and contraceptive agents: a systematic in vitro study. [PDF]

PLoS ONE, 2008
BACKGROUND: The urgent need for cheap and easy-to-use protection against both unwanted pregnancies and sexually transmitted diseases has stimulated considerable interest in the use of surfactants as microbicides, anti-viral, and contraceptive agents in ...
Otilia V Vieira, Diego O Hartmann, Carla M P Cardoso, Daniel Oberdoerfer, Marta Baptista, Manuel A S Santos, Luis Almeida, João Ramalho-Santos, Winchil L C Vaz   +8 more
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance [PDF]

, 2016
Influenza viruses cause annual seasonal epidemics and occasional pandemics. It is important to elucidate the stringency of bottlenecks during transmission to shed light on mechanisms that underlie the evolution and propagation of antigenic drift, host ...
Ashcroft, J, Barclay, W, Bradley, K, Donnelly, C, Elderfield, R, Fernandez-Alonso, M, Frise, R, Galiano, M, Lackenby, A, Miah, S, Roberts, K, Stilwell, P, Van Doremalen, N   +12 more
core   +1 more source

Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8+ resident memory T cells

Immunology &Cell Biology, EarlyView.
Abstract Tissue‐resident memory (Trm) CD8+ T cells in the upper and lower respiratory tract play an instrumental role in combatting influenza virus. While CD8+ Trm populations in these compartments differ in longevity and developmental requirements, it remains unclear whether they share clonotypes, indicating a common origin, or are seeded by distinct ...
Thi H O Nguyen, Hayley A McQuilten, Angela Pizzolla, Sneha Sant, Kim L Harland, Jessica Braverman, Katherine Kedzierska, Linda M Wakim   +7 more
wiley   +1 more source

Protective essential oil attenuates influenza virus infection: An in vitro study in MDCK cells

BMC Complementary and Alternative Medicine, 2010
Background Influenza is a significant cause of morbidity and mortality. The recent pandemic of a novel H1N1 influenza virus has stressed the importance of the search for effective treatments for this disease. Essential oils from aromatic plants have been
Metcalf Jordan P, Booth Leland J, Patel Krupa B, Wu Shuhua, Lin Hsueh-Kung, Wu Wenxin   +5 more
doaj   +1 more source