Results 71 to 80 of about 57,848 (220)

The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. [PDF]

, 1998
We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK)
Chapin, SJ, Kömüves, LG, Low, SH, Mostov, KE, Weimbs, T, Whiteheart, SW, Wimmer, C   +6 more
core  

Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]

, 2017
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R., Bryant, David M., Gao, Lei, Hiremath, Chitkale, Long, Blake, Luby-Phelps, Katherine, Marciano, Denise K., Mostov, Keith E., Yang, Zhufeng, Zimmerman, Susan E.   +9 more
core   +2 more sources

Nutritional, phytochemical, and potential health benefits of Monostroma spp.: A systematic review

Food Biomacromolecules, EarlyView.
Abstract Monostroma spp., belonging to the green seaweed, has been known to be health‐promoting food items as prophylactic agents worldwide. It has shown wide arrays of bioactivities for the prevention and treatment of various diseases. A total of 47 articles were selected to review following the Preferred Reporting Items for Systematic reviews and ...
Md Shariful Islam
wiley   +1 more source

The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus. [PDF]

, 2013
BackgroundThe current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus.FindingsA/Anhui/1/2013 (H7N9) virus was administered by intranasal instillation to groups of mice and ...
Bao, Linlin, Chen, Ting, Deng, Wei, Gao, Kai, Huang, Lan, Li, Fengdi, Li, Yanhong, Liu, Jiangning, Lv, Qi, Qin, Chuan, Wei, Qiang, Xiang, Zhiguang, Xu, Lili, Xu, Yanfeng, Yao, Yanfeng, Yong, Weidong, Yu, Pin, Yuan, Jing, Zhang, Lianfeng, Zhu, Hua   +19 more
core   +3 more sources

Amino Acids Regulate Transgene Expression in MDCK Cells

PLoS ONE, 2014
Gene expression and cell growth rely on the intracellular concentration of amino acids, which in metazoans depends on extracellular amino acid availability and transmembrane transport. To investigate the impact of extracellular amino acid concentrations on the expression of a concentrative amino acid transporter, we overexpressed the main kidney ...
Torrente M., Guetg A., Sass J., Arps L., Ruckstuhl L., Camargo S.M., Verrey F.   +6 more
openaire   +6 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Effect of size, shape, and surface modification on cytotoxicity of gold nanoparticles to human Hep-2 and canine MDCK cells [PDF]

, 2012
There have been increasing interests in applying gold nanoparticles in biological research, drug delivery, and therapy. As the interaction of gold nanoparticles with cells relies on properties of nanoparticles, the cytotoxicity is complex and still under
Chen, Yu, Li, Wenqin, Xu, Dan, Yu, Jun, Zhang, Yinan   +4 more
core   +3 more sources

Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus

Vaccine, 2019
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of influenza vaccine seed viruses for humans on the basis of primary virus isolation efficiency, growth ability, genetic stability of the hemagglutinin (HA)
Kazuya, Nakamura, Yuichi, Harada, Hitoshi, Takahashi, Heidi, Trusheim, Roth, Bernhard, Itsuki, Hamamoto, Asumi, Hirata-Saito, Teruko, Ogane, Katsumi, Mizuta, Nami, Konomi, Yasushi, Konomi, Hideki, Asanuma, Takato, Odagiri, Masato, Tashiro, Norio, Yamamoto   +14 more
openaire   +2 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

Neurobiology of Disease, 2008
The pathogenesis of Alzheimer’s disease is characterized by aggregation of the amyloid-β protein (Aβ) into neurotoxic plaques. Recent in vivo studies have suggested the non-proteolytic clearance of Aβ via receptor-mediated transport across the blood ...
Babak Nazer, Soyon Hong, Dennis J. Selkoe   +2 more
doaj   +1 more source