Results 51 to 60 of about 57,848 (220)

Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]

, 2006
PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E., Moon, D.J., Obara, T., Ong, A.C.M., Streets, A.J.   +4 more
core   +2 more sources

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]

, 2008
Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +3 more
core   +2 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Evaluation of near infrared dyes as markers of P-glycoprotein activity in tumors

Frontiers in Pharmacology, 2016
Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and poor patient prognosis.
Inessa Semenenko, Emma Portnoy, Mohammed AbouKaoud, Serge Guzy, Serge Guzy, Miri Shmuel, Gal Itzhak, Sara Eyal   +7 more
doaj   +1 more source

Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood–Brain Barrier in Patients with Glioblastoma

Pharmaceutics, 2023
Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmost ...
Bárbara Sánchez-Dengra, Elena García-Montoya, Isabel González-Álvarez, Marival Bermejo, Marta González-Álvarez   +4 more
doaj   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions

Pharmaceutics, 2012
The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) <em>in vitro</em> drug absorption model.
Balvinder S. Vig, Ronald L. Smith, Teresa N. Faria, Doris A. Wall, Aiqing He, Charles A. Tilford, Yisheng Jin, Yong Quan   +7 more
doaj   +1 more source

A system for production of defective interfering particles in the absence of infectious influenza A virus

, 2019
Influenza A virus (IAV) infection poses a serious health threat and novel antiviral strategies are needed. Defective interfering particles (DIPs) can be generated in IAV infected cells due to errors of the viral polymerase and may suppress spread of wild
Arora, P., Bdeir, N., Gärtner, S., Hoffmann, M., Pöhlmann, S., Reichl, U., Winkler, M.   +6 more
core   +2 more sources

Synthesis of carbohydrate capped silicon nanoparticles and their reduced cytotoxicity, in vivo toxicity, and cellular uptake [PDF]

, 2015
The development of smart targeted nanoparticles (NPs) that can identify and deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. Obtaining knowledge
Ahire, Ahire, Barthel, Buford, Chandrasekaran, Chen, Dai, Danishefsky, Deguchi, dos Santos, Dwek, Erogbogbo, Fako, Foucaud, Fricker, Gerber, Giannaccini, Gliga, Hakomori, Hakomori, Harding, Hu, Jenei, Johannessen, Kayser, Kayser, Kim, Kim, Kirchner, Lee, Lerchen, Lidsky, Lingwood, Liu, Macher, Mahmoudi, Marcon, Mayne, Mercer, Moghimi, Moore, Moros, Murdock, Nangia-Makker, Nazarian, Nieuwkoop, Nilsson, O'Farrell, Pascual, Pastan, Petitou, Pieters, Rabinovich, Raman, Rojo, Rye, Sager, Schrag, Seeberger, Seker, Sherwood, Silverstein, Simanek, Sofer, Straussman, Su, Tjelle, Tseng, Vankuppeveld, Varki, Villanueva, Wang, Wang, Werz, Wick, Willingham, Wilson   +76 more
core   +1 more source