Results 41 to 50 of about 33,145 (176)
Ganglioside GM2 is substrate for a sialidase in MDCK cells
FEBS Letters, 1998 GM1 ganglioside carrying a fluorescent fatty acid in substitution of the natural one, has been administered to cultured Madin‐Darby canine kidney (MDCK) cells for different pulse times (0.5–24 h), and its metabolic fate was followed. The fluorescent GM2, asialo‐GM2, asialo‐GM1 and ceramide were the only detectable metabolites.
MARCHESINI, Sergio +4 more
openaire +2 more sources
Mechanisms of RON-mediated epithelial-mesenchymal transition in MDCK cells through the MAPK pathway
Brazilian Journal of Medical and Biological Research, 2011 The epithelial-mesenchymal transition (EMT) is involved in neoplastic metastasis, and the RON protein may be involved. In the present study, we determined the role and the mechanisms of action of RON in EMT in Madin-Darby canine kidney (MDCK) cells by ...
Xu Xiangming +4 more
doaj +1 more source
Shear-induced Volume Decrease in MDCK Cells [PDF]
Cellular Physiology and Biochemistry, 2012 Using a microfluidic cell volume sensor we measured the change in the cell volume of Madin-Darby Canine Kidney (MDCK) cells induced by shear stress. An increase in shear stress from 0.2 to 2.0 dyn/cm(2) resulted in a volume decrease to a steady state volume ∼ 20 - 30 % smaller than the initial resting cell volume.
Jinseok, Heo +3 more
openaire +2 more sources
Higher titers of some H5N1 and recent human H1N1 and H3N2 influenza viruses in Mv1 Lu vs. MDCK cells
Virology Journal, 2011 Background The infectivity of influenza A viruses can differ among the various primary cells and continuous cell lines used for such measurements. Over many years, we observed that all things equal, the cytopathic effects caused by influenza A subtype ...
Daniels Deirdre E +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
FEBS Open Bio, 2019 Nuclear factor of activated T cells 5 (NFAT5) is a transcription factor involved in the regulation of several genes involved in the response to extracellular hyperosmolality. Recently, the uptake of ibuprofen by an as yet unknown carrier was suggested in
Rune Nørgaard Rasmussen +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo +4 more
wiley +1 more source
Evaluation of near infrared dyes as markers of P-glycoprotein activity in tumors
Frontiers in Pharmacology, 2016 Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and poor patient prognosis.
Inessa Semenenko +7 more
doaj +1 more source
Pharmaceutics, 2023 Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmost ...
Bárbara Sánchez-Dengra +4 more
doaj +1 more source