Results 61 to 70 of about 33,145 (176)

Covalently Immobilized Lignin–Xanthene Conjugates for Persistent Surface Photochemistry and Self‐Sterilizing Interfaces Under Ambient Visible Light

Macromolecular Rapid Communications, EarlyView.
Bio‐derived lignin–Eosin Y macromolecular networks are developed as visible‐light‐responsive self‐sterilizing coatings that generate reactive oxygen species without leaching. The spray‐coated photopolymerized surfaces exhibit durable antibacterial and antiviral activity under ambient light for extended periods, demonstrating a scalable and sustainable ...
Euna Oh, Surjith Kumaran, Sumin Han, Kiseok Lee, Hyerin Shin, Seokmin Oh, Dae‐Hong Ko, Hyo‐Jick Choi   +7 more
wiley   +1 more source

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

Neurobiology of Disease, 2008
The pathogenesis of Alzheimer’s disease is characterized by aggregation of the amyloid-β protein (Aβ) into neurotoxic plaques. Recent in vivo studies have suggested the non-proteolytic clearance of Aβ via receptor-mediated transport across the blood ...
Babak Nazer, Soyon Hong, Dennis J. Selkoe   +2 more
doaj   +1 more source

Comparison of mutation patterns in full-genome A/H3N2 influenza sequences obtained directly from clinical samples and the same samples after a single MDCK passage. [PDF]

PLoS ONE, 2013
Human influenza viruses can be isolated efficiently from clinical samples using Madin-Darby canine kidney (MDCK) cells. However, this process is known to induce mutations in the virus as it adapts to this non-human cell-line.
Hong Kai Lee, Julian Wei-Tze Tang, Debra Han-Lin Kong, Tze Ping Loh, Donald Kok-Leong Chiang, Tommy Tsan-Yuk Lam, Evelyn Siew-Chuan Koay   +6 more
doaj   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Properties and regulation of ion channels in MDCK cells

Kidney International, 1995
The MDCK cell has proven to be a useful model cell line for the study of properties and regulation of renal epithelial ion channels. Patch clamp studies disclosed the existence of several K+ channels and of a Cl- channel, and their regulation by hormones, cell volume, trace elements and drugs.
Lang, Florian, Paulmichl, Markus
openaire   +2 more sources

Production, Passaging Stability, and Histological Analysis of Madin–Darby Canine Kidney Cells Cultured in a Low-Serum Medium

Vaccines
Madin–Darby canine kidney (MDCK) cells are commonly used to produce cell-based influenza vaccines. However, the role of the low-serum medium on the proliferation of MDCK cells and the propagation of the influenza virus has not been well studied.
Ming Cai, Yang Le, Zheng Gong, Tianbao Dong, Bo Liu, Minne Su, Xuedan Li, Feixia Peng, Qingda Li, Xuanxuan Nian, Hao Yu, Zheng Wu, Zhegang Zhang, Jiayou Zhang   +13 more
doaj   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Glycosphingolipid synthesis is essential for MDCK cell differentiation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Glycosphingolipids (GSLs), which are highly concentrated at the apical membrane of polarized epithelial cells, are key components of cell membranes and are involved in a large number of processes. Here, we investigated the ability of hypertonicity (high salt medium) to induce Madin-Darby Canine Kidney (MDCK) cell differentiation and found an increase ...
Pescio, Lucila Gisele, Favale, Nicolas Octavio, Marquez, Maria Gabriela, Sterin, Norma Beatriz   +3 more
openaire   +3 more sources

Influenza entry pathways in polarized MDCK cells

Biochemical and Biophysical Research Communications, 2014
In non-polarized cell culture models, influenza virus has been shown to enter host cells via multiple endocytic pathways, including classical clathrin-mediated endocytic routes (CME), clathrin- and caveolae-independent routes and macropinocytosis. However, little is known about the entry route of influenza virus in differentiated epithelia, in vivo ...
Zhang, Yueting, Whittaker, Gary R.
openaire   +2 more sources

Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells [PDF]

The Journal of Cell Biology, 1998
Abstract. We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER. The oligomers become larger, increasingly detergent insoluble, and phosphorylated on caveolin-2 during transport to the cell ...
SCHEIFFELE P, VERKADE P, FRA, Annamaria, VIRTA H, SIMONS K, IKONEN E.   +5 more
openaire   +3 more sources