Results 221 to 230 of about 644,957 (254)

Small-molecule MDM2 inhibitors in clinical trials for cancer therapy

European Journal of Medicinal Chemistry, 2022
Fen-Er Chen
exaly  

Synthetic Design and Biological Evaluation of New p53-MDM2 Interaction Inhibitors Based on Imidazoline Core

Pharmaceuticals, 2022
Kopeina Gelina, Natalia Lozinskaya, Daniil Bazanov   +2 more
exaly  

Synthesis of an MDM2 Inhibitor

Synfacts, 2013
openaire   +1 more source

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

Bioorganic Chemistry, 2021
El Sayed H El Ashry, Mohamed M Said, Marwa Abu-Serie   +2 more
exaly  

Combination of immunotherapies with MDM2 inhibitors

2020
YANG DAJUN, ZHAI YIFAN, FANG DOUGLAS DONG, TANG QIUQIONG   +3 more
openaire   +3 more sources

PROCESSES FOR PREPARING A MDM2 INHIBITOR

2020
CAILLE SEBASTIEN, CORBETT MICHAEL, SMITH AUSTIN   +2 more
openaire   +2 more sources

The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy

European Journal of Medicinal Chemistry, 2018
Guochao Liao, Zhongqiu Liu, Lixin Duan   +2 more
exaly  

SPIROPYRROLIDINES AS MDM2 INHIBITORS

2015
CHEN YI, DING QINGJIE JACK, SUN YANG-SHENG   +2 more
openaire   +4 more sources

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

Journal of Medicinal Chemistry, 2015
Denzil Bernard, Shaomeng Wang, Yujun Zhao   +2 more
exaly  

Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Bioorganic and Medicinal Chemistry Letters, 2016
Sébastien Jeay, Achim Schlapbach, Andrea Vaupel   +2 more
exaly