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Strategies for p53 Activation and Targeted Inhibitors of the p53-Mdm2/MdmX Interaction [PDF]

Cells
p53 is a tumor suppressor gene and is regarded as one of the most crucial genes in protecting humans against cancer. The protein Mdm2 and its homolog MdmX serve as negative regulators of p53.
Ye Huang, Wang Li, Yuke Zhou, Jinping Bai, Ning Li, Zhengding Su, Xiyao Cheng   +6 more
doaj   +4 more sources

MDMX in Cancer: A Partner of p53 and a p53-Independent Effector

Biologics: Targets and Therapy
Wu Lin,1,* Yuxiang Yan,2,* Qingling Huang,1 Dali Zheng2 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People’s Republic of China; 2Fujian Key Laboratory of Oral Diseases ...
Dali Zheng, Yuxiang Yan
exaly   +5 more sources

Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53 [PDF]

Biomolecules
p53 functions as a critical guardian of the genome, orchestrating tumor suppression pathways and ensuring the integrity of chromosomal stability. Mdm2 and MdmX, homologous proteins, serve as negative feedback regulators of p53.
Qiuyin Wei, Chenqi Li, Yibing Tang, Jinping Bai, Wang Li, Jidong Liu, Zhengding Su, Xiyao Cheng   +7 more
doaj   +4 more sources

MDMX reprograms glycolysis of hepatocellular carcinoma via 14-3-3γ/FOXO1 [PDF]

Cell Death Discovery
MDMX serves as a significant regulator of p53, which is a crucial tumor suppressor protein. However, the biological functions and underlying mechanism of MDMX in hepatocellular carcinoma (HCC) remain inadequately understood. In this study, we demonstrate
Han Chen, Qilong Pan, Meiqi Mao, Wu Lin, Sisi Yan, Jie Liu, Shuoqi Lin, Qin Li, Sihui Xue, Yixuan Xie, Lincan Ding, Dali Zheng, Jie You, Qingling Huang   +13 more
doaj   +3 more sources

Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway [PDF]

Cell Death Discovery
The lymphotoxin β receptor (LTβR), a key activator of non-canonical NF-κB signaling, is expressed in various cells, including cancer cells. Although high expression of LTβR has been associated with poor patient prognosis and drug resistance, conflicting ...
So Young Kim, Bin Lee, Je-Jung Lee, Man Sup Kwak, Woo Joong Rhee, In Ho Park, Jeon-Soo Shin   +6 more
doaj   +3 more sources

FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53 [PDF]

Oncogenesis
Aberrant Receptor Tyrosine Kinase (RTK) signaling allows cancer cells to modulate survival, proliferation, and death, leading to tumorigenesis and chemoresistance.
Djazia Haferssas, Marion Dubuissez, Jonatan Barrera-Chimal, Clémence Messmer, El Bachir Affar, Bruno Larrivée, Xue-Song Liu, Casimiro Gerarduzzi   +7 more
doaj   +3 more sources

Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA. [PDF]

Biosci Rep
The two murine double minute (MDM) family members, MDM2 and MDMX, are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX)
Kucerikova M, Bonczek O, Olivares-Illana V, Rodriguez-Rodriguez A, Sampedro JG, Hernychova L, Hrabal V, Zatloukalova P, Krejcir R, Fahraeus R, Coates PJ, Vojtesek B, Martinkova L.   +12 more
europepmc   +3 more sources

Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling [PDF]

Proteomes
Background: We utilized data-independent acquisition (DIA) to study the poorly understood biology of Mdm2 and MdmX in a p53-null context. Mdm2 and MdmX form an E3-ligase complex that has as its most well-studied function the negative regulation of the ...
Anu Jain, Rafaela Muniz de Queiroz, Jayanta K. Chakrabarty, Karl A. T. Makepeace, Carol Prives, Lewis M. Brown   +5 more
doaj   +3 more sources

Study on the design, synthesis and activity of MDM2/MDMX anti-tumor stapled peptide PROTAC [PDF]

Scientific Reports
PROTAC is a drug development technology that uses the Ubiquitin-Proteasome System (UPS) to degrade target proteins, and enhances the degradation ability of target proteins through E3 ubiquitin ligase, which can further enhance the anti-tumor effect of ...
Xiufei Liao, Mao Guo, Damin Hu, Chunli Su, Hongli Liao   +4 more
doaj   +3 more sources

An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway [PDF]

Cells
Mdmx (Mdm4) is established as an oncogene mainly through repression of the p53 tumour suppressor. On the other hand, anti-oncogenic functions for Mdmx have also been proposed, but the underlying regulatory pathways remain unknown. Investigations into the
Lara J. Bou Malhab, Susanne Schmidt, Christine Fagotto-Kaufmann, Emmanuelle Pion, Gilles Gadea, Pierre Roux, Francois Fagotto, Anne Debant, Dimitris P. Xirodimas   +8 more
doaj   +3 more sources