Results 31 to 40 of about 7,268 (227)
Regulation of p53: a collaboration between Mdm2 and Mdmx [PDF]
Oncotarget, 2012 p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 negative regulators.
Zhang, Yanping +2 more
core +4 more sources
Raman active diyne-girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores† [PDF]
RSC Chemical BiologyPeptide stapling is an effective strategy to stabilise α-helical peptides, enhancing their bioactive conformation and improving physiochemical properties. In this study, we apply our novel diyne-girder stapling approach to the MDM2/MDMX α-helical binding
Danielle C. Morgan +8 more
doaj +2 more sources
Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53 [PDF]
Nature CommunicationsAlthough the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that do not involve p53.
Rafaela Muniz de Queiroz +7 more
doaj +2 more sources
Inhibitors of MDM2 and MDMX: a structural perspective
Future Medicinal Chemistry, 2009 p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation and is therefore frequently deleted or mutated in cancer.
Riedinger, Christiane +3 more
core +4 more sources
BMC Molecular and Cell Biology, 2021 Background MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2.
Jack D. Sanford +5 more
doaj +1 more source
MdmX inhibits Smad transactivation [PDF]
Oncogene, 2002 Mdm2 overexpression confers a growth promoting activity upon cells primarily by downregulating the p53 tumor suppressor protein. Nevertheless, Mdm2 deregulation has also been implicated in inhibiting TGF-beta growth repression in a p53 independent manner.
Kadakia, Madhavi +3 more
openaire +4 more sources
Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways. [PDF]
PLoS ONE, 2014 MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essential for maintaining homeostasis within the cell. In response to genotoxic stress and also in several cancer types, MDM2 and MDMX are alternatively spliced ...
Aishwarya G Jacob +6 more
doaj +1 more source
MDMX under stress: the MDMX-MDM2 complex as stress signals hub [PDF]
Translational Cancer Research, 2016 The tumor suppressor p53 plays a central role in safeguarding cellular homeostasis. Upon various types of stress signals such as DNA damage or oncogenic stress, p53 is promptly activated to prevent and repair damages that can threaten the genome stability. The two major negative regulators of p53 are MDM2 and MDMX, two homolog proteins that control p53
Anna, de Polo +3 more
openaire +2 more sources
Mdmx and Mdm2: Brothers in Arms? [PDF]
Cell Cycle, 2004 The p53 tumor suppressor pathway is inactivated in most if not all human tumors. In about 50% of the cases this is accomplished directly by gene mutations. The tumors that retain wild type p53 frequently show defects either in effector target genes, or in the expression of p53 regulatory proteins.
Jean-Christophe, Marine +1 more
openaire +2 more sources
MdmX Represses E2F1 Transactivation [PDF]
Cell Cycle, 2004 Based on knockout mouse studies, Mdm2 and MdmX have been identified as critical regulators of the p53 tumor suppressor protein, at least during early development. While many of the functions attributed to Mdm2 and MdmX involve p53 and overexpression of each gene appears to have oncogenic activities, a number of studies have suggested that each protein ...
Mark, Wunderlich +3 more
openaire +2 more sources