Results 51 to 60 of about 7,268 (227)

Regulation of MDMX Expression by Mitogenic Signaling [PDF]

Molecular and Cellular Biology, 2008
MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene amplification are implicated in p53 inactivation and tumor development. Unlike MDM2, MDMX is not inducible by p53, and little is known about its regulation at the transcriptional level.
Daniele M, Gilkes, Yu, Pan, Domenico, Coppola, Timothy, Yeatman, Gary W, Reuther, Jiandong, Chen   +5 more
openaire   +2 more sources

A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein. [PDF]

PLoS ONE, 2017
MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for ...
Georgios Valianatos, Barbora Valcikova, Katerina Growkova, Amandine Verlande, Jitka Mlcochova, Lenka Radova, Monika Stetkova, Michaela Vyhnakova, Ondrej Slaby, Stjepan Uldrijan   +9 more
doaj   +1 more source

Identification of a Novel Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) Ligand that Disrupts HnRNPA2B1/Nucleic Acid Interactions to Inhibit the MDMX-p53 Axis in Gastric Cancer.

Pharmacological Research, 2023
Gastric carcinoma is a highly malignant tumor that still lacks effective molecular targets. Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is an essential oncogenic driver overexpressed in various cancers.
Lei Hu, Shuqi Liu, Hong-Ying Yao, Yue-Miao Hu, Yingjie Wang, Jing Jiang, Xiaopeng Li, Fenghua Fu, Qi-Kun Yin, Hong-Bo Wang   +9 more
semanticscholar   +1 more source

MdmX is a substrate for the deubiquitinating enzyme USP2a [PDF]

Oncogene, 2009
It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of the Mdm2/p53 pathway. USP2a binds to Mdm2 and can deubiquitinate Mdm2 without reversing Mdm2-mediated p53 ubiquitination. Overexpression of USP2a causes accumulation of Mdm2 and promotes p53 degradation. We now show that MdmX is also a substrate for USP2a.
Allende-Vega, N., Sparks, A., Lane, D. P., Saville, M. K.   +3 more
openaire   +3 more sources

Mdm2 and MdmX as Regulators of Gene Expression [PDF]

Genes & Cancer, 2012
p53 is an important tumor suppressor, functioning as a transcriptional activator and repressor. Upon receiving signals from multiple stress related pathways, p53 regulates numerous activities such as cell cycle arrest, senescence, and cell death. When p53 activities are not required, the protein is held in check by interacting with 2 key homologous ...
Lynn, Biderman, James L, Manley, Carol, Prives   +2 more
openaire   +2 more sources

Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage.

PLoS Computational Biology, 2010
Tumor suppressor protein p53 is regulated by two structurally homologous proteins, Mdm2 and MdmX. In contrast to Mdm2, MdmX lacks ubiquitin ligase activity.
Sohyoung Kim, Mirit I Aladjem, Geoffrey B McFadden, Kurt W Kohn   +3 more
doaj   +1 more source

The roles and regulation of MDM2 and MDMX: it is not just about p53

Genes & Development, 2021
In this review, Klein et al. discuss the p53-independent roles of MDM2 and MDMX. First, they review the structural and functional features of MDM2 and MDMX proteins separately and together that could be relevant to their p53-independent activities ...
Alyssa M. Klein, R. M. de Queiroz, D. Venkatesh, C. Prives   +3 more
semanticscholar   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Unraveling the role of <i>TP53</i> mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation. [PDF]

Hemasphere
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
da Silva-Benedito S, Bernardo PS, Martin JE, Marty C, Plo I, Antony-Debré I, Monte-Mór BDCR.   +6 more
europepmc   +2 more sources

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Frontiers in Cell and Developmental Biology, 2020
The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating cancer cell growth, proliferation, cell cycle progression, apoptosis, senescence ...
Si-Min Qi, Gang Cheng, Xiang-Dong Cheng, Zhiyuan Xu, Beihua Xu, Wei-Dong Zhang, Wei-Dong Zhang, Jiang-Jiang Qin, Jiang-Jiang Qin   +8 more
doaj   +1 more source