Results 71 to 80 of about 7,268 (227)
ACS Medicinal Chemistry Letters, 2023 Cyclic peptides have been expected to be one of the modalities of intracellular protein-protein interaction (PPI) inhibitors, but they are generally known to have low cell membrane permeability.
Mai Mizuno-Kaneko +7 more
semanticscholar +1 more source
MDM2-ALT1 and MDMX-ALT2 interact with full-length MDM2 and MDMX.
, 2014 A. Full-length MDM2 is encoded by exons 3 to 12 of the MDM2 gene and consists of the N-terminal p53-binding domain, the nuclear localization (NLS) and export signals (NES), the central ARF binding and Zinc finger domains and the C-terminal RING domain ...
Thomas W. Bebee (611924) +6 more
core +1 more source
MDM2 Promotes Ubiquitination and Degradation of MDMX [PDF]
Molecular and Cellular Biology, 2003 The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation. Mitogenic signals activate p53 by induction of ARF expression, which inhibits p53 ubiquitination by MDM2. Recent studies showed that the MDM2 homolog MDMX is also an important regulator of p53.
Yu, Pan, Jiandong, Chen
openaire +2 more sources
PLoS ONE, 2015 The p53-MDMX interaction has attracted extensive attention of anti-cancer drug development in recent years. This current work adopted molecular dynamics (MD) simulations and cross-correlation analysis to investigate conformation changes of MDMX caused by
Shuhua Shi +2 more
doaj +1 more source
Breast Cancer Research, 2019 Introduction Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive (ERα+) breast cancer and triple-negative breast cancer (TNBC).
Chong Gao +5 more
doaj +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang +6 more
wiley +1 more source
RPL37, RPS15, and RPS20 bind to and regulate MdmX levels.
, 2013 (a–c) Association of RPs and MdmX. H1299 cells were transfected with HA-MdmX (0.5 µg), Myc-RP (1.2 µg), or both. (GFP was added as a control for transfection efficiency.) Ectopic MdmX and RP levels were detected by immunoblotting with α-MdmX and α-Myc ...
Xavier Jacq (433920) +3 more
core +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
rHSA-P53i and rHSA-PMI bind to MDM2 and MDMX.
, 2013 To detect the interaction between MDM2/MDMX and rHSA fusion proteins, 4 µg each of biotinylated rHSA (lane 1), rHSA-P53i (lane 2), or rHSA-PMI (lane 3) were added to 200 µg of SJSA-1 whole cell lysate.
Zhiyu Li (10983) +3 more
core +1 more source
Advanced Science, Volume 13, Issue 60, 28 October 2026.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source