Results 91 to 100 of about 7,268 (227)

MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors

iScience
Summary Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune cells,
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W Partridge, Long Jiang, F. Wermeling, David P. Lane, Marika Nestor, D. Spiegelberg   +9 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, Volume 20, Issue 3, Page 804-822, March 2026.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors. [PDF]

, 2018
Targeting the protein-protein interaction between p53 and MDM2/MDMX (MDM4) represents an attractive anticancer strategy for the treatment of p53-competent tumors.
Sébastien RG Galan (24058914), Jakub Stefaniak (5760155), Carole JR Bataille (24058917), Graham M Wynne (24058920), Andrew Lewis (23879073), M Paola Castaldi (24058923), Angela J Russell (24058926), Thomas Lundbäck (762303), Kilian VM Huber (24058929), Daniel Conole (4475164)   +9 more
core   +2 more sources

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Regulation of Mdmx and its role in the p53 pathway [PDF]

, 2006
The p53 protein is an important tumor suppressor that acts as a key regulator of the integrity of the genome. Two essential regulators of the p53 protein are Mdm2 and its homologue Mdmx. Like Mdm2, Mdmx represses p53-induced transcription.
Meulmeester, Erik
core  

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

, 2011
MdmX, also known as Mdm4, is a critical negative regulator of p53, and its overexpression serves to block p53 tumor suppressor function in many cancers.
Matthew R. Warr, Lamorna Brown Swigart, Carla P. Martins, Daniel Garcia, Emmanuelle Passegué, Gerard I. Evan   +5 more
core   +1 more source

THE ION CHANNEL TRPM7 REGULATES ZINC DEPLETION-INDUCED MDMX DEGRADATION [PDF]

, 2021
Zinc deficiency has been linked to human diseases including cancer. p53, a zinc-containing transcription factor, is the most frequently mutated tumor suppressor protein in human cancer.
Wang, Herui
core  

LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX

Cell Death Discovery, 2023
LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism of its action remains largely unknown.
Qingqing Zhao, Wei He, Zhouheng Liu, Liangliang Huang, Xiaoli Yang, Yong Liu, Rui Chen, Xun Min, Yan Yang   +8 more
doaj   +1 more source

Cross-correlation matrices of the fluctuations of the coordinates for C_α atoms of MDMX around their mean positions during the equilibrium phase of simulations.

, 2015
The extents of correlated motions and anticorrelated motions are color-coded for four binding complexes: A for PMI-MDMX, B for pDI-MDMX, C for WK23-MDMX and D for WW8-MDMX.
Qinggang Zhang (819761), Shuhua Shi (418270), Shaolong Zhang (819760)   +2 more
core   +1 more source

A Small-Molecule p53 Activator Induces Apoptosis through Inhibiting MDMX Expression in Breast Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2011
The tumor suppressor p53 is often inactivated in breast cancer cells because the overexpression of its repressors (e.g., MDM2 and MDMX). Restoration of p53 activity by small molecules through counteracting p53 repressors can lead to in vivo tumor ...
Hongbo Wang, Chunhong Yan
doaj   +1 more source