Results 81 to 90 of about 7,268 (227)

The p53-MDM2/MDMX axis – A chemotype perspective [PDF]

MedChemComm, 2011
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 consists of the most intense studied PPI with a group of small molecular weight antagonists described and many more disclosed in patent literature. Due to the Å-level structural insight into p53 interaction with MDM2 there is a reasonable understanding of ...
Khoury, K., Popowicz, G., Holak, T., Domling, A.   +3 more
openaire   +3 more sources

Quantitative and Targeted Regulation of Ferroptosis in Bladder Cancer: Preclinical Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT The activation of ferroptosis, a cell death mechanism driven by excessive ferrous ions (Fe2+) and lipid peroxides, has emerged as a promising target for cancer treatment. However, in the case of quantitative regulation of target genes, it remains uncertain whether ferroptosis can be induced in bladder cancer (BCa) cells without affecting ...
Ying Dong, Chaojie Xu, Bing Yan, Shuanzhu Mou, Chen Li, Yuchen Liu   +5 more
wiley   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source

Abstract 1205: Frequent detection of MDMX isoforms in human ovarian carcinomas

, 2010
The p53 tumor suppressor pathway is inactivated in many human tumors either by p53 mutations or through overexpression of negative regulators, such as MDM2 and MDMX.
Julia Richter, Frank Bartel, Claudia Loebel, Anja Wolf, Christoph Thomssen, Steffen Hauptmann   +5 more
core   +1 more source

Mdm2 and MdmX partner to regulate p53

FEBS Letters, 2012
Mdm2 regulates the stability, translation, subcellular localization and transcriptional activity of p53 protein. Mdm2‐dependent p53 inhibition is essential in regulating p53 activity during embryonic development and in adult tissues. MdmX, an Mdm2 homolog, is also essential for p53 inhibition in vivo.
Wang, Xinjiang, Jiang, Xuejun
openaire   +2 more sources

Effects of MdmX on Mdm2‐mediated downregulation of pRB [PDF]

FEBS Letters, 2006
Mdm2, a RING‐finger type ubiquitin ligase, is overexpressed in a variety of human cancers. It promotes ubiquitination of the tumor suppressor p53 and can function as an oncogene by largely downregulating p53. Recently, we reported that Mdm2 degrades retinoblastoma tumor suppressor protein (pRB) via the ubiquitin–proteasome system. In the present study,
Uchida, Chiharu, Miwa, Seiichi, Isobe, Tomoyasu, Kitagawa, Kyoko, Hattori, Takayuki, Oda, Toshiaki, Yasuda, Hideyo, Kitagawa, Masatoshi   +7 more
openaire   +2 more sources

Immunohistochemistry for p16 and p53 Provides Substantial Agreement With Molecular Tests in Penile Cancer

Pathology International, Volume 76, Issue 6, June 2026.
In penile squamous cell carcinoma, p16 and p53 immunohistochemistry showed substantial concordance with molecular testing (Cohen's kappa 0.6–0.7). Aberrant p53 expression profiles (overexpression or null phenotype) were associated with significantly worse survival.
Jan Hrudka, Jan Hojný, Eva Krkavcová, Jiří Dvořák, Zuzana Prouzová, Michaela Kendall Bártů, Nicolette Zavillová, David Čapka, Radoslav Matěj, Petr Waldauf   +9 more
wiley   +1 more source

Therapeutic Strategies to Activate p53

Pharmaceuticals, 2022
The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of ...
Angelo Aguilar, Shaomeng Wang
doaj   +1 more source

Role of Mdm2 and Mdmx in DNA repair [PDF]

Journal of Molecular Cell Biology, 2017
Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex ...
openaire   +2 more sources

USP49 stabilizes MDMX and suppresses PPARα activity to mitigate isoproterenol-induced heart failure in preclinical models

Journal of Radiation Research and Applied Sciences
Background: Ubiquitin-specific peptidase 49 (USP49) has been implicated in cardioprotection, yet its role in heart failure (HF) and the associated mechanism are poorly understood. This study deciphered the function of USP49 in HF and its interaction with
Lushuang Huang, Na Li, Wei Zhang
doaj   +1 more source