Results 41 to 50 of about 7,268 (227)

MDMX: from bench to bedside [PDF]

Journal of Cell Science, 2007
The tumor suppressor protein p53 is negatively regulated by Mdm2, a ubiquitin ligase protein that targets p53 for degradation. Mdmx (also known as Mdm4) is a relative of Mdm2 that was identified on the basis of its ability to physically interact with p53.
Marine, Jean-Christophe, DYER, MA, JOCHEMSEN, AG   +2 more
openaire   +3 more sources

A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

Frontiers in Physiology, 2019
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53.
Pavlína Kosztyu, Iva Slaninová, Barbora Valčíková, Barbora Valčíková, Amandine Verlande, Amandine Verlande, Petr Müller, Jan J. Paleček, Jan J. Paleček, Stjepan Uldrijan, Stjepan Uldrijan   +10 more
doaj   +1 more source

MDM4 (MDMX) and its Transcript Variants [PDF]

Current Genomics, 2009
MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family. The human gene is located on chromosome 1 at q32-33 and codes for a protein of 490aa.
Mancini F. 1, 2, Di Conza G. 1, 3, Moretti F. 1   +4 more
openaire   +4 more sources

Functions of MDMX in the Modulation of the p53‐Response [PDF]

BioMed Research International, 2011
The MDM family proteins MDM2 and MDMX are two critical regulators of the p53 tumor suppressor protein. Expression of both proteins is necessary for allowing the embryonal development by keeping the activity of p53 in check. Upon stresses that need to activate p53 to perform its function as guardian of the genome, p53 has to be liberated from these two ...
Lenos, K., Jochemsen, A.G.
openaire   +3 more sources

Detektion und Charakterisierung von MDMX-Isoformen in humanen Ovarialtumoren [PDF]

, 2012
In dieser Arbeit wurde in einem Kollektiv von 34 postoperativ eingefrorenen ovariellen Tumorproben die Expression von MDMX-Transkripten untersucht. In 16 der 34 Tumorproben konnten zusätzlich zur bereits charakterisierten Variante MDMX-S zahlreiche neue ...
Löbel, Claudia
core   +1 more source

Molecular Basis for the Inhibition of p53 by Mdmx [PDF]

Cell Cycle, 2007
The oncoprotein Mdm2, and the recently intensely studied, homologues protein Mdmx, are principal negative regulators of the p53 tumor suppressor. The mechanisms by which they regulate the stability and activity of p53 are not fully established. We have determined the crystal structure of the N-terminal domain of Mdmx bound to a 15-residue p53 peptide ...
Popowicz, G., Czarna, A., Rothweiler, U., Szwagierczak, A., Krajewski, M., Weber, L., Holak, T.   +6 more
openaire   +3 more sources

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Nature Communications, 2022
Peptide fragments derived from the interfaces of protein-protein interactions (PPIs) provide useful templates for designing small molecule PPI inhibitors.
Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su   +8 more
doaj   +1 more source

Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Verbenalin is a major compound in Verbena officinalis L. Verbena officinalis L was first recorded in the 'Supplementary Records of Famous Physicians.' Verbenalin (VE) is its active constituent and has been found to have ...
Jiahui Dong, Chang-Lin Du, Chuanting Xu, Qi Wang, Zhonghao Wang, Qiang Zhu, Xiong-Wen Lv, Lei Zhang, Jun Li, Cheng Huang, Hua Wang, Tao-Tao Ma   +11 more
semanticscholar   +1 more source

Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics [PDF]

BioDiscovery, 2013
Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately half of human cancers, the tumor suppressor function of p53 is inactivated by deletion or mutation of TP53, the gene encoding p53 protein.
Yujun Zhao, Denzil Bernard, Shaomeng Wang   +2 more
doaj   +3 more sources

Untersuchungen zum Spleißvorgang von MDMX nach DNA-Schäden in der Ovarialkarzinomzelllinie OAW-42 [PDF]

, 2014
MDMX ist ein negativer Regulator des Tumorsuppressors p53. Genotoxischer Stress führt zum veränderten Spleißen und vermehrt zur Bildung von MDMX-Isoformen. In OAW-42 Zellen (wt-p53) wurde nach Behandlung mit Cisplatin erhöhtes Exon 6 Skipping detektiert.
Wolf, Anja
core   +1 more source