Results 21 to 30 of about 7,268 (227)
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling [PDF]
Genes & Development, 2020 Here, Venkatesh et al. investigated the p53-independent roles of MDMX and the MDM2–MDMX complex. They found that MDM2 and MDMX facilitate ferroptosis in cells with or without p53, and that PPARα activity is essential for MDM2 and MDMX to promote ...
D. Venkatesh +16 more
semanticscholar +2 more sources
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
Frontiers in Oncology, 2020 The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is often amplified and highly expressed
Li Yuan, Jiangjiang Qin, Can Hu
exaly +3 more sources
Scientific Reports, 2022 Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation.
Haomin Yan +13 more
doaj +3 more sources
Computational Analysis of the Homologous Mouse Double RINGs Interface for Targeted Anticancer Drug Design [PDF]
BiomedicinesBackground/Objectives: The new yearly 1.1 million cancer cases and considerably increasing mortality, after decades of decline, require urgent and effective therapy.
Adeniyi Thompson Adewumi +4 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2021 Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo, representing a viable therapeutic strategy for cancer treatment.
William D Tolbert, Wangxiao He, Si Chen
exaly +3 more sources
Peli1 Modulates the Subcellular Localization and Activity of Mdmx [PDF]
Cancer Research, 2018 Mdm2 and Mdmx, both major repressors of p53 in human cancers, are predominantly localized to the nucleus and cytoplasm, respectively. The mechanism by which subcellular localization of Mdmx is regulated remains unclear.
Dawei Li +3 more
core +3 more sources
Chemokine CXCL12 Activates CXC Receptor 4 Metastasis Signaling Through the Upregulation of a CXCL12/CXCR4/MDMX (MDM4) Axis. [PDF]
Cancers (Basel)Simple Summary Breast cancer metastasis is promoted by a number of factors, including signaling from the stromal cell-derived factor 1 (SDF-1) to the CXC Receptor 4 (CXCR4), and mutations in the TP53 gene in combination with the upregulation of Mouse ...
Lee R +11 more
europepmc +2 more sources
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells [PDF]
Molecules, 2019 Tumor suppressor p53 is mutated in about 50% of cancers. Most malignant melanomas carry wild-type p53, but p53 activity is often inhibited due to overexpression of its negative regulators Mdm2 or MdmX.
Zuzana Mrkvová +4 more
doaj +3 more sources
Pharmacological Research, 2022 Dysfunction of p53 is observed in many malignant tumors, which is related to cancer susceptibility. In cervical cancer, p53 is primarily degradated through the complex of high-risk human papillomaviruses (HPV) oncoprotein E6 and E6-associated protein ...
Jingwen Zhang +9 more
doaj +2 more sources
Computational-based drug design of novel small molecules targeting p53-MDMX interaction
Journal of Biomolecular Structure and Dynamics, 2023 The regulation of the p53 tumor suppressor pathway is critically dependent on the activity of Murine Double Minute 2 (MDM2) and Murine Double Minute X (MDMX) proteins.
A. Egbemhenghe +15 more
semanticscholar +2 more sources