Results 11 to 20 of about 7,268 (227)

Discovery of a Phenylalanine-Derived Natural Compound as a Potential Dual Inhibitor of MDM2 and MDMX. [PDF]

ChemMedChem
Dual inhibition of the negative p53 regulators MDM2 and MDMX has emerged as an effective strategy in p53‐based anticancer therapy. However, dual inhibitors are limited, and many inhibitors exhibit poor pharmacokinetic properties and fast dissociation ...
Cho JY, Park S, Kim T, Eom J, Rho JR, Bai HW.   +5 more
europepmc   +3 more sources

Controlling the Mdm2-Mdmx-p53 Circuit [PDF]

Pharmaceuticals, 2010
The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular stress signals.
David L. Waning, Jason A. Lehman, Christopher N. Batuello, Lindsey D. Mayo   +3 more
doaj   +4 more sources

Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX

Molecules, 2022
A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities.
Yali Wang, Bo Ji, Zhongshui Cheng, Lianghui Zhang, Yingying Cheng, Yingying Li, Jin Ren, Wenbo Liu, Yuanyuan Ma   +8 more
doaj   +2 more sources

MDMX enhances radiosensitivity in lung adenocarcinoma and squamous cell carcinoma by inhibiting P53-mediated autophagy. [PDF]

Cell Oncol (Dordr)
Radioresistance is a common cause of poor radiation therapy effectiveness for non-small cell lung cancer. Finding molecular targets or methods to enhance radiosensitivity or overcome radioresistance is crucial. This study aimed to investigate the effects
Ji NN, Li SN, Shao L, Li Q, Xu JN, Zeng YC.   +5 more
europepmc   +2 more sources

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin. [PDF]

Nucleic Acids Res
DNA damage signaling requires functional interactions between 53BP1 and the wild-type p53 tumor suppressor. Cancer cells often express elevated levels of transcriptionally inactive mutant p53 (mtp53) that maintains MDM2 and MDMX (MDM4) binding partners ...
Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J.   +8 more
europepmc   +2 more sources

Bionic Power Play: Dual-Targeting MDMX/MDM2 to Reboot p53 to Beat Lung Adenocarcinoma's Immune Tricks. [PDF]

Int J Nanomedicine
Background and Aim MDM2 and MDMX are key regulators of the tumor suppressor p53 and are implicated in immune escape mechanisms in lung adenocarcinoma.
Wong S, Xu L, You W, He W, Zheng X, Qi Z.   +5 more
europepmc   +2 more sources

Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Disruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far.
Keting Li, Wenshu Hu, Yingjie Wang, Wenxing Chen, Hongmei Wen, Jian Liu, Wei Li, Bo Wang   +7 more
doaj   +2 more sources

Insight Into the Binding Mechanism of p53/pDIQ-MDMX/MDM2 With the Interaction Entropy Method [PDF]

Frontiers in Chemistry, 2019
The study of the p53-MDMX/MDM2 binding sites is a research hotspot for tumor drug design. The inhibition of p53-targeted MDMX/MDM2 has become an effective approach in anti-tumor drug development.
Mengxin Li, Yalong Cong, Yuchen Li, Susu Zhong, Ran Wang, Hao Li, Hao Li, Lili Duan   +7 more
doaj   +2 more sources

Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis

Scientific Reports, 2023
The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX inhibits cellular p53 activity, which is highly relevant to cancer occurrence. Coiled-coil
Ting Zhou, Zhiqiang Ke, Qianqian Ma, Jiani Xiang, Meng Gao, Yongqi Huang, Xiyao Cheng, Zhengding Su   +7 more
doaj   +2 more sources

The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX

Journal of Molecular Biology, 2022
Autoinhibition of p53 binding to MDMX requires two short-linear motifs (SLiMs) containing adjacent tryptophan (WW) and tryptophan-phenylalanine (WF) residues.
Borcherds, Wade, Chen, Jiandong, Levy, Robin, Wade Borcherds, Asokan Anbanandam, Fenton, Malissa, Malissa Fenton, Chen, Lihong, Anbanandam, Asokan, Gary Daughdrill, Daughdrill, Gary W., Lihong Chen, Jiandong Chen, Robin Levy   +13 more
core   +4 more sources