Results 71 to 80 of about 644,957 (254)

Targeting MDM2 in malignancies is a promising strategy for overcoming resistance to anticancer immunotherapy

Journal of Biomedical Science
MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor (ICI) treatment for different malignancies by various pancancer studies.
Dantong Sun, Haili Qian, Junling Li, Puyuan Xing   +3 more
doaj   +1 more source

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

Cancer Cell International, 2019
The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 ubiquitin ligase, and the ubiquitinated p53 can be transferred to the cytoplasm and
Helei Hou, Dantong Sun, Xiaochun Zhang
doaj   +1 more source

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.

, 2013
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth leading cause of cancer death in the western world, with a 5-year survival rate below 5%.
Conradt, Laura;Henrich, Annika;Wirth, Matthias;Reichert, Maximilian;Lesina, Marina;Algül, Hana;Schmid, Roland M;Krämer, Oliver H;Saur, Dieter;Schneider, Günter
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

8-(triazolyl)purine inhibitors of MDM2/p53.

, 2015
8-(triazolyl)purine inhibitors of MDM2/p53.
Jesper R. Nilsson (734942), Jaeki Min (160374), Morten Grøtli (216956), R. Kiplin Guy (160393), Mariell Pettersson (734939), David Bliman (734940), Richard W. Kriwacki (734944), Luigi Iconaru (734943), Joakim Andréasson (734945), Jimmy Jacobsson (734941)   +9 more
core   +1 more source

Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

, 2023
Disruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far.
Bo Wang (86769), Wei Li (7081), Hongmei Wen (748425), Jian Liu (33711), Wenshu Hu (17596899), Keting Li (6273920), Yingjie Wang (354135), Wenxing Chen (352859)   +7 more
core   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

, 2016
Small-molecule inhibitors that block the MDM2-p53 protein–protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment.
Denzil Bernard (1348401), Donna McEachern (573068), Philippe Ochsenbein (1534477), Vincent Ferey (1555249), Wei Sun (93580), Xiaoqin, Li (1958869), Jeffrey R. Deschamps (1331481), Jianfeng Lu (294884), Liu Liu (512237), Shaomeng Wang (88290), Yujun Zhao (216850), Shanghai Yu (1958866), Jean-Christophe Carry (1692826), Duxin Sun (501117)   +13 more
core   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source