Results 11 to 20 of about 40,945 (273)

Safety pharmacology of acute MDMA administration in healthy subjects [PDF]

Journal of Psychopharmacology, 2017
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is being investigated in MDMA-assisted psychotherapy. The present study characterized the safety pharmacology of single-dose administrations of MDMA (75 or 125 mg) using data from nine double-blind ...
Patrick Vizeli, Matthias E Liechti
exaly   +4 more sources

Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder

Frontiers in Psychiatry, 2023
Introduction3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) has demonstrated promise in multiple clinical trials.
S. Parker Singleton, Julie B. Wang, Michael Mithoefer, Michael Mithoefer, Colleen Hanlon, Mark S. George, Mark S. George, Annie Mithoefer, Oliver Mithoefer, Allison R. Coker, Allison R. Coker, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin, Amy Kuceyeski, Amy Kuceyeski   +15 more
doaj   +2 more sources

A Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy

Frontiers in Psychiatry, 2019
This paper provides a brief review of the history, proposed pharmacological mechanisms, safety issues, and clinical applications of the medicine 3,4-methylenedioxymethamphetamine (MDMA). Most clinical MDMA research in patients to date has focused on MDMA-
Ben Sessa, Laurie Higbed, David Nutt
doaj   +2 more sources

Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder

European Journal of Psychotraumatology
Background: MDMA-assisted psychotherapy (MDMA-AP) is a combined psychotherapeutic and pharmacologic intervention that shows promise in the treatment of posttraumatic stress disorder (PTSD).
Richard J. Zeifman, Hannes Kettner, Stephen Ross, Brandon Weiss, Michael C. Mithoefer, Ann T. Mithoefer, Anne C. Wagner   +6 more
doaj   +2 more sources

Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study

Intensive Care Medicine Experimental, 2020
Background 3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure.
Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied, Achim Lother   +7 more
doaj   +2 more sources

Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Ecstasy is a popular recreational psychostimulant with side effects on the central nervous system. This study examined the corpus striatum tissue of adult rats that received ecstasy during the embryonic period for histological and molecular
Zahra Nazari, Khadijeh Bahrebar, Mohammad Jafar Golalipour   +2 more
doaj   +1 more source

White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels

NeuroImage: Clinical, 2022
3,4–Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a serotonin- and noradrenaline-releasing substance, currently among the most widely used illicit substances worldwide.
Josua Zimmermann, Nicole Friedli, Francesco Bavato, Philipp Stämpfli, Rebecca Coray, Markus R. Baumgartner, Denis Grandgirard, Stephen L. Leib, Antje Opitz, Erich Seifritz, Ann-Kathrin Stock, Christian Beste, David M. Cole, Boris B. Quednow   +13 more
doaj   +1 more source

MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study.

Focus, 2023
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial ...
Jennifer M. Mitchell, M. Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, K. Parker-Guilbert, M. Ot’alora G., W. Garas, Casey Paleos, I. Gorman, Christopher R. Nicholas, M. Mithoefer, Shannon Carlin, Bruce Poulter, A. Mithoefer, Sylvestre Quevedo, G. Wells, Sukhpreet Klaire, B. A. van der Kolk, Keren Tzarfaty, R. Amiaz, Ray Worthy, Scott M. Shannon, J. Woolley, C. Marta, Yevgeniy Gelfand, Emma Hapke, Simon Amar, Yair Wallach, Randall W. Brown, S. Hamilton, Julie B. Wang, A. Coker, Rebecca Matthews, A. de Boer, B. Yazar-Klosinski, A. Emerson, R. Doblin   +37 more
semanticscholar   +1 more source

Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants

Neuropsychopharmacology, 2023
There is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective effects of LSD are mostly positive, negative subjective effects, including anxiety, may occur.
I. Straumann, L. Ley, F. Holze, A. Becker, A. Klaiber, Kathrin Wey, Urs Duthaler, N. Varghese, A. Eckert, M. Liechti   +9 more
semanticscholar   +1 more source

Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations

Scientific Reports, 2023
MDMA is a stimulant-like drug with distinctive empathogenic effects. Its pro-social effects, such as feelings of connectedness, may contribute to both its popularity as a recreational drug and its apparent value as an adjunct to psychotherapy.
Hanna M Molla, Royce Lee, Sonja Lyubomirsky, Harriet de Wit   +3 more
semanticscholar   +1 more source