Results 21 to 30 of about 10,083 (200)

Protective effect of pentoxifylline on male Wistar rat testicular germ cell apoptosis induced by 3,4-methylenedioxymeth amphetamine [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): 3, 4-methylenedioxymethamphetamine (MDMA) one of the methamphetamine derivatives that affect the reproductive system, has not been well understood.
Mahnaz Nouri, Shabnam Movassaghi, Alireza foroumadi, Mansooreh Soleimani, Zahra Nadia Sharifi   +4 more
doaj  

Effects of 3,4-Methylenedioxymethamphetamine on Conditioned Fear Extinction and Retention in a Crossover Study in Healthy Subjects

Frontiers in Pharmacology, 2022
Background: 3,4-Methylenedioxymethamphetamine (MDMA) has shown initial promise as an adjunct in psychotherapy to treat posttraumatic stress disorder (PTSD). Its efficacy and safety have been demonstrated across phase I–III studies. However, the mechanism
Patrick Vizeli, Patrick Vizeli, Patrick Vizeli, Isabelle Straumann, Isabelle Straumann, Urs Duthaler, Urs Duthaler, Nimmy Varghese, Nimmy Varghese, Anne Eckert, Anne Eckert, Martin P. Paulus, Victoria Risbrough, Victoria Risbrough, Matthias E. Liechti, Matthias E. Liechti   +15 more
doaj   +1 more source

MDMA-assisted psychotherapy for people diagnosed with treatment-resistant PTSD: what it is and what it isn’t

Annals of General Psychiatry, 2020
Background PTSD is a chronic condition with high rates of comorbidity, but current treatment options are limited and not always effective. One novel approach is MDMA-assisted psychotherapy for people diagnosed with treatment-resistant PTSD, where MDMA is
Louise Morgan
doaj   +1 more source

Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA

Journal of Neuroinflammation, 2011
Background Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a ...
Mayado Andrea, Torres Elisa, Gutierrez-Lopez Maria D, Colado Maria I, O'Shea Esther   +4 more
doaj   +1 more source

Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.

PLoS ONE, 2018
Methylenedioxymethamphetamine (MDMA) increases oxytocin, empathy, and prosociality. Oxytocin plays a critical role in emotion processing and social behavior and has been shown to mediate the prosocial effects of MDMA in animals. Genetic variants, such as
Patrick Vizeli, Matthias E Liechti
doaj   +1 more source

Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. [PDF]

PLoS ONE, 2016
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) is a commonly abused recreational drug that causes neurotoxic effects in both humans and animals. The mechanism behind MDMA-induced neurotoxicity is suggested to be species-dependent and needs to be ...
Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson   +3 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicit

Basic and Clinical Neuroscience, 2020
N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body’s systems, which its mechanism of action and treatment should be more investigated.
Nor Suliana Mustafa, Nor Hidayah Abu Bakar, Nasir Mohamad, Liyana Hazwani Mohd Adnan, Nurul Farah Aina Md Fauzi, Abdulsoma Thoarlim, Syed Hadzrullathfi Syed Omar, Mohd Shafiee Hamzah, Zawawi Yusoff, Mahdi Jufri, Rashidi Ahmad   +10 more
doaj  

The influence of genetic and environmental factors among MDMA users in cognitive performance. [PDF]

PLoS ONE, 2011
This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA.
Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré, Rafael de la Torre   +12 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source