Results 31 to 40 of about 33,449 (240)

The influence of genetic and environmental factors among MDMA users in cognitive performance. [PDF]

PLoS ONE, 2011
This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA.
Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré, Rafael de la Torre   +12 more
doaj   +1 more source

Visuospatial working memory impairment in current and previous ecstasy/polydrug users [PDF]

, 2011
Objective: Previous research suggests that ecstasy users are impaired in processing visuospatial information. However, for the most part, the deficits observed appear to involve the recall and recognition of complex visual and geometric patterns.
Back-Madruga, Bedi, Bhattachary, Bolla, Brown, Brown, Buchert, Cabeza, Chang, Chase, Dafters, Dean, Dickson, Fisk, Fisk, Fisk, Fox, Fox, Gouzoulis-Mayfrank, Halpern, Hanson, Martin, McCann, McCann, McCarthy, Miyake, Montgomery, Oliveri, Raven, Rodgers, Schilt, Semple, Smith-Spark, Sola Llopis, Solowij, Verkes, Wareing, Wareing, Yip   +38 more
core   +1 more source

Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. [PDF]

PLoS ONE, 2016
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) is a commonly abused recreational drug that causes neurotoxic effects in both humans and animals. The mechanism behind MDMA-induced neurotoxicity is suggested to be species-dependent and needs to be ...
Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson   +3 more
doaj   +1 more source

Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder

Frontiers in Psychiatry, 2023
Introduction3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) has demonstrated promise in multiple clinical trials.
S. Parker Singleton, Julie B. Wang, Michael Mithoefer, Michael Mithoefer, Colleen Hanlon, Mark S. George, Mark S. George, Annie Mithoefer, Oliver Mithoefer, Allison R. Coker, Allison R. Coker, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin, Amy Kuceyeski, Amy Kuceyeski   +15 more
doaj   +1 more source

Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA

Journal of Neuroinflammation, 2011
Background Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a ...
Mayado Andrea, Torres Elisa, Gutierrez-Lopez Maria D, Colado Maria I, O'Shea Esther   +4 more
doaj   +1 more source

Effects of ecstasy/polydrug use on memory for associative information [PDF]

, 2012
Rationale Associative learning underpins behaviours that are fundamental to the everyday functioning of the individual. Evidence pointing to learning deficits in recreational drug users merits further examination.
A Klugman, A Miyake, AD Castel, AJ Sankoh, AJ Verdejo-García, BG Tabachnick, C Montgomery, C Montgomery, C Montgomery, Catharine Montgomery, DC Howell, Denis T. Gallagher, E Gouzoulis-Mayfrank, E O’Shea, F Indlekofer, G Jager, GMP Roberts, HC Fox, J Brown, J Cohen, J Lawston, J Raven, J Tanji, JE Fisk, JE Fisk, Jeannie Judge, John E. Fisk, JR Law, K McCardle, KI Bolla, L Messinis, M Moscovitch, M Moscovitch, M Wareing, MJ Morgan, MT Reinitz, MT Reinitz, N Solowij, NEA Kroll, Paul J. Taylor, PM Thompson, PN Murphy, RE Passingham, RH Logie, RJ Croft, RJ Croft, S Darke, Sarita J. Robinson, T Schilt, Y Sekine   +49 more
core   +1 more source

Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.

PLoS ONE, 2018
Methylenedioxymethamphetamine (MDMA) increases oxytocin, empathy, and prosociality. Oxytocin plays a critical role in emotion processing and social behavior and has been shown to mediate the prosocial effects of MDMA in animals. Genetic variants, such as
Patrick Vizeli, Matthias E Liechti
doaj   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]

, 2019
copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria, Chilcott, Robert, Corazza, Ornella, Corkery, John, Guirguis, Amira, Marrinan, Shanna, Martinotti, Giovanni, Zloh, Mire   +7 more
core   +3 more sources

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie International Edition, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +1 more source