Results 51 to 60 of about 15,040 (247)

MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicit

Basic and Clinical Neuroscience, 2020
N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body’s systems, which its mechanism of action and treatment should be more investigated.
Nor Suliana Mustafa, Nor Hidayah Abu Bakar, Nasir Mohamad, Liyana Hazwani Mohd Adnan, Nurul Farah Aina Md Fauzi, Abdulsoma Thoarlim, Syed Hadzrullathfi Syed Omar, Mohd Shafiee Hamzah, Zawawi Yusoff, Mahdi Jufri, Rashidi Ahmad   +10 more
doaj  

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Effects of MDMA on body temperature in humans [PDF]

, 2014
Hyperthermia is a severe complication associated with the recreational use of 3,4-methylenedioxymethamphetamine(MDMA, Ecstasy). In this review, the clinical laboratory studies that tested the effects of MDMA on body temperature are summarized.
Liechti, Matthias E.
core  

Hvor farlig er MDMA? [PDF]

, 2022
Jamt og medarbeidere publiserer nå i Tidsskriftet en studie der man har observert en økning i antallet rettslig obduserte dødsfall og antallet pågrepne ruspåvirkede førere med funn av 3,4-metylendioksymetamfetamin (MDMA) i blodet, samtidig som man har ...
Frost, Joachim
core   +1 more source

The influence of genetic and environmental factors among MDMA users in cognitive performance. [PDF]

PLoS ONE, 2011
This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA.
Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré, Rafael de la Torre   +12 more
doaj   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Verbal memory deficits are correlated with prefrontal hypometabolism in (18)FDG PET of recreational MDMA users. [PDF]

PLoS ONE, 2013
INTRODUCTION: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a recreational club drug with supposed neurotoxic effects selectively on the serotonin system. MDMA users consistently exhibit memory dysfunction but there is an ongoing debate if these
Oliver G Bosch, Michael Wagner, Frank Jessen, Kai-Uwe Kühn, Alexius Joe, Erich Seifritz, Wolfgang Maier, Hans-Jürgen Biersack, Boris B Quednow   +8 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Chronic exposure to MDMA (Ecstasy) elicits behavioral sensitization in rats but fails to induce cross-sensitization to other psychostimulants

Behavioral and Brain Functions, 2006
Background The recreational use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) among adolescents and young adults has become increasingly prevalent in recent years.
Swann Alan C, Yang Pamela B, Modi Gunjan M, Dafny Nachum   +3 more
doaj   +1 more source