Results 71 to 80 of about 15,040 (247)

MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor

Frontiers in Pharmacology, 2017
Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism underlying these psychedelic ...
Drew J. Puxty, Johannes G. Ramaekers, Rafael de la Torre, Rafael de la Torre, Rafael de la Torre, Magí Farré, Magí Farré, Magí Farré, Neus Pizarro, Neus Pizarro, Mitona Pujadas, Mitona Pujadas, Kim P. C. Kuypers   +12 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signalling [PDF]

, 2015
Novel psychoactive substances are newly used designer drugs ("internet drugs", "research chemicals", "legal highs") potentially posing similar health risks to classic illicit substances. Chemically, many novel psychoactive substances can be classified as
Liechti, Matthias E., Matthias Liechti
core   +1 more source

Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat.

PLoS ONE, 2011
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known to produce euphoric states, but may also cause adverse consequences in humans, such as hyperthermia and neurocognitive deficits. Although MDMA consumption has been associated with visual problems,
João Martins, Miguel Castelo-Branco, Ana Batista, Bárbara Oliveiros, Ana Raquel Santiago, Joana Galvão, Eduarda Fernandes, Félix Carvalho, Cláudia Cavadas, António F Ambrósio   +9 more
doaj   +1 more source

Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. [PDF]

PLoS ONE, 2014
Autophagic (type II) cell death, characterized by the massive accumulation of autophagic vacuoles in the cytoplasm of cells, has been suggested to play pathogenetic roles in cerebral ischemia, brain trauma, and neurodegenerative disorders.
I-Hsun Li, Kuo-Hsing Ma, Shao-Ju Weng, Shiang-Suo Huang, Chang-Min Liang, Yuahn-Sieh Huang   +5 more
doaj   +1 more source

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source

Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study

Intensive Care Medicine Experimental, 2020
Background 3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure.
Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied, Achim Lother   +7 more
doaj   +1 more source

Changes over time in hallucinogen‐related emergency department visits in Ontario, Canada

Addiction, EarlyView.
Abstract Background and aims Recent increasing interest in hallucinogens has underscored the critical gaps in our understanding of their adverse health effects and healthcare usage over time. The current study aimed to examine changes in emergency department (ED) visit rates involving hallucinogens, clinical outcomes of visits and the characteristics ...
Daniel T. Myran, Rachael MacDonald‐Spracklin, Alexander R. Levesque, Michael Pugliese, Jess G. Fiedorowicz, André J. McDonald, Joshua D. Rosenblat, Ian Colman, Josephine Zein, Marco Solmi   +9 more
wiley   +1 more source

Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice

Behavioral and Brain Functions, 2010
Background Numerous reports indicate that MDMA users consume other psychoactive drugs, among which cannabis is one of the most common. The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid ...
Miñarro José, Aguilar María A, Maldonado Concepción, Daza-Losada Manuel, Rodríguez-Arias Marta, Manzanedo Carmen   +5 more
doaj   +1 more source

High temporal resolution monitoring of illicit drug consumption across England via wastewater analysis

Addiction, EarlyView.
Abstract Aim To monitor community‐level consumption of 20 illicit drugs across urban areas of England using wastewater‐based epidemiology (WBE) surveillance at high temporal resolution. Design, setting, cases This study was conducted over a 12‐month period in 2022 sampling 24‐hour composite wastewater samples at 15 wastewater treatment plants (WWTPs ...
Helena Rapp‐Wright, Keng Tiong Ng, Derryn Grant, William Francis, Margarita White, Dimitris Evangelopoulos, Yuxing Liu, Konstantina Dimakopoulou, Sofia Zafeiratou, Dylan Wood, Chryshanthi Christy, Stav Friedman, Timothy W. Gant, Klea Katsouyanni, Leon P. Barron   +14 more
wiley   +1 more source