Results 81 to 90 of about 40,945 (273)

Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects [PDF]

, 2017
In vitro studies showed that CYP2C19, CYP2B6, and CYP1A2 contribute to the metabolism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to 3,4-methylenedioxyamphetamine (MDA).
Liechti, Matthias E., Meyer Zu Schwabedissen, Henriette E., Prestin, Katharina, Schmid, Yasmin, Vizeli, Patrick   +4 more
core   +1 more source

Integrating the Gestalt Model of Self With Psychedelic‐Assisted Psychotherapy

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT This theoretical integration paper employs a conceptual analysis methodology to synthesize the Gestalt model of self‐as‐process with Psychedelic Somatic Interactional Psychotherapy (PSIP). Unlike traditional psychedelic therapy models that defer therapeutic engagement to postsession integration, PSIP emphasizes an active, directive therapeutic
Travis R. Fox
wiley   +1 more source

Chronic exposure to MDMA (Ecstasy) elicits behavioral sensitization in rats but fails to induce cross-sensitization to other psychostimulants

Behavioral and Brain Functions, 2006
Background The recreational use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) among adolescents and young adults has become increasingly prevalent in recent years.
Swann Alan C, Yang Pamela B, Modi Gunjan M, Dafny Nachum   +3 more
doaj   +1 more source

Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats [PDF]

, 2018
MDMA causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-HT may, inter alia, increase impulsivity. To study the effects of MDMA upon brain function, the behaviour of male Dark Agouti rats
Andó Rómeó, Bagd, György, Benko A, Ferrington L, Kelly PAT, Kirilly Eszter   +5 more
core   +1 more source

RETRACTED ARTICLE: Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy

Psychopharmacology, 2020
MDMA-assisted psychotherapy is under investigation as a novel treatment for posttraumatic stress disorder (PTSD). The primary mechanism of action of MDMA involves the same reuptake transporters targeted by antidepressant medications commonly prescribed ...
A. Feduccia, L. Jerome, M. Mithoefer, Julie A. Holland   +3 more
semanticscholar   +1 more source

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD

Brain, Behavior, & Immunity - Health, 2022
Post-traumatic stress disorder (PTSD) is a devastating disorder that involves maladaptive changes in immune status. Using the stress-enhanced fear learning (SEFL) paradigm, an animal model of PTSD, our laboratory has demonstrated increased pro ...
Shveta V. Parekh, Lydia O. Adams, Gillian A. Barkell, Donald T. Lysle   +3 more
doaj   +1 more source

Temporal and visual source memory deficits among ecstasy/polydrug users [PDF]

, 2014
Objectives: The present paper seeks to investigate whether source memory judgements are adversely affected by recreational illicit drug use. Method: Sixty-two ecstasy/polydrug users and 75 non ecstasy users completed a source memory task, in which they ...
Beatty, Bedi, Benjamini, Berry, Burke, Chalfonte, Davis, Duarte, Ferguson, Green, Halpern, Indlekofer, Johnson, Johnson, Johnson, Kahn, Kausler, Kausler, Kish, Lindsay, Lindsay, McCann, McCann, Meiser, Mitchell, Mitchell, Multhaup, Murphy, Murphy, Narum, Nulsen, Parrott, Raven, Rosselli, Schilt, Scholey, Shimamura, Smith, Strømsø, Thomasius, Tomasi, Unsworth, Vignali, Yacoubian, Zaldívar, Zaragoza   +45 more
core   +2 more sources

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

The Chemical Record, EarlyView.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim, Solpa Lee, Anmo J. Kim, Cong Wang, Yongwoo Jang   +4 more
wiley   +1 more source

Improving drug identification in overdose death surveillance by using clinical natural language processing models

Journal of Forensic Sciences, EarlyView.
Abstract The rising rate of drug‐related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free‐text coroner reports, leading to delays and information loss when coded into ICD (International Classification of Disease)‐10 classifications.
Arthur J. Funnell, Panayiotis Petousis, Fabrice Harel‐Canada, Ruby Romero, Alex A. T. Bui, Adam Koncsol, Hritika Chaturvedi, Chelsea Shover, David Goodman‐Meza   +8 more
wiley   +1 more source