Results 121 to 130 of about 7,268 (227)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, Volume 19, Issue 8, Page 2412-2430, August 2025.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers.

PLoS ONE, 2020
Loss of retinoblastoma (RB) function in the cone cells during retina development is necessary but not sufficient for retinoblastoma development. It has been reported that in the absence of RB activity, a retinoma is generated, and the onset of retina ...
Mayra Martínez-Sánchez, Mariana Moctezuma-Dávila, Jesús Hernandez-Monge, Martha Rangel-Charqueño, Vanesa Olivares-Illana   +4 more
doaj   +1 more source

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

Frontiers in Pharmacology, 2017
The MDM2 and MDMX oncogenes are overexpressed in various types of human cancer and are highly associated with the initiation, progression, metastasis and chemotherapeutic resistance of these diseases, including prostate cancer.
Jiang-Jiang Qin, Jiang-Jiang Qin, Xin Li, Xin Li, Wei Wang, Wei Wang, Wei Wang, Xiaolin Zi, Xiaolin Zi, Ruiwen Zhang, Ruiwen Zhang, Ruiwen Zhang   +11 more
doaj   +1 more source

Study on the design, synthesis, and activity of anti-tumor staple peptides targeting MDM2/MDMX

Frontiers in Chemistry
Staple peptides, which have a significantly enhanced pharmacological profile, are promising therapeutic molecules due to their remarkable resistance to proteolysis and cell-penetrating properties.
Jian Yang, Xiufei Liao, Damin Hu, Jinqiu Mo, Xiurong Gao, Hong-Li Liao   +5 more
semanticscholar   +1 more source

Focused Library Generator: case of Mdmx inhibitors

Journal of Computer-Aided Molecular Design, 2019
We present a Focused Library Generator that is able to create from scratch new molecules with desired properties. After training the Generator on the ChEMBL database, transfer learning was used to switch the generator to producing new Mdmx inhibitors that are a promising class of anticancer drugs.
Zhonghua Xia, Pavel Karpov, Grzegorz M. Popowicz, Igor V. Tetko   +3 more
openaire   +5 more sources

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

Journal of Hematology & Oncology, 2017
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of cancer.
Veronica Tisato, Rebecca Voltan, Arianna Gonelli, Paola Secchiero, Giorgio Zauli   +4 more
doaj   +1 more source

Structure of MDM2-MDMX-UbcH5B-ubiquitin complex

, 2017
Crystal structure reveal how MDM2-MDMX complex recriuits E2~ubiquitin ...
Vousden, Karen, Huang, Danny, Sibbet, Gary, Hock, Andreas, Nomura, Koji, Kowalczyk, Dominika, Klejnot, Marta, M. Klejnot, D.T. Huang   +8 more
core   +1 more source

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2) [PDF]

, 2017
Mouse double minute 2 (Mdm2) and MdmX dimerize in response to low levels of genotoxic stress to function in a ubiquitinating complex, which signals for destabilization of p53.
David J. Olivos, McAtarsney, Ciaran P., Eric R. Wolf, Paula M. Hauck, Hauck, Paula M., Lindsey D. Mayo, Ciaran P. McAtarsney, Olivos, David J., Mayo, Lindsey D., Wolf, Eric R.   +9 more
core   +1 more source

Regulation of MDMX Nuclear Import and Degradation by Chk2 and 14-3-3

, 2007
The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and degradation by MDM2.
LeBron, Cynthia
core  

Structural Studies on the MDM2-MDMX Heterodimer / [PDF]

, 2013
MDM2 is a protein that regulates p53 to prevent it from performing its tumor suppressor functions. In normal cells, MDM2 acts as an ubiquitin ligase to promote p53 degradation by attaching ubiquitin and sending it to the proteasome.
Sano, Eleanor Shoko
core