Results 131 to 140 of about 7,268 (227)
MdmX regulates transformation and chromosomal stability in p53-deficient cells [PDF]
, 2009 The cellular homologues Mdm2 and MdmX play critical roles in regulating the activity of the p53 tumor suppressor in damaged and non-damaged cells and during development in mice.
Matijasevic, Zdenka +3 more
core +1 more source
Stochastic Modeling and Simulation of the p53-MDM2/MDMX Loop
, 2009 The p53 gene is crucial for effective tumor suppression in humans as supported by its universal inactivation in cancer cells either through mutations affecting the p53 locus directly or through aberration of its normal regulation. The p53 tumor repressor
Cai, Xiaodong +3 more
core +1 more source
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
, 2008 The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human ...
Czarna, Anna (author) +2 more
core +1 more source
Beni-Suef University Journal of Basic and Applied SciencesBackground The MDMX-p53 and MDM2-p53 interactions are critical regulators of the tumor-suppressive functions of p53, often disrupted in cancers through overexpression of murine double minute X (MDMX) and murine double minute 2 (MDM2).
Olanrewaju Ayodeji Durojaye +7 more
doaj +1 more source
ChemMedChemDepletion of the tumor‐suppressor TP53 is known to open the door to cancer and, after 30 years of research, no remedy has been approved. When TP53 depletion is due to trapping by MDM2, a key requisite for non‐covalent inhibitors is high affinity for MDM2
Francesco Pietra
semanticscholar +1 more source
The Regulation Mechanism of MdmX in Axin-p53Signaling Pathway
, 2014 鼠双微体基因X(MdMX)是肿瘤抑制因子P53信号通路中重要的负调控蛋白,它能与P53直接结合,抑制P53的转录活性.体轴发育抑制因子AXIn作为构架蛋白与P53及同源结构域互作蛋白激酶2(HIPk2)等相互作用形成复合物,诱导P53的转录活化,共同促进细胞的凋亡.本研究将MdMX引入AXIn-P53信号通路的调控中,发现MdMX通过竞争AXIn与P53的结合,抑制AXIn诱导P53的转录激活.P53结合区域缺失的MdMX突变体MdMXΔP53则不能抑制AXIn对P53的激活 ...
叶志云, 贺颖
core
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
, 2011 There are currently two distinct models proposed to explain why both MDM2 and MDMX are required in p53 control, with a key difference centered on whether these two p53 inhibitors work together or independently.
Jie Yang +10 more
core +1 more source
, 2007 Mdm2 is a member of the RING finger family of ubiquitin ligases and is best known for its role in targeting the tumor suppressor p53 for ubiquitination and degradation.
Singh, Rajesh K. +2 more
core +1 more source
Efficient Reactivation of p53 in Cancer Cells by a Dual MdmX/Mdm2 Inhibitor
, 2016 The aberrant interaction between p53 and Mdm2/MdmX is an attractive target for cancer drug discovery because the overexpression of Mdm2 and/or MdmX ultimately impairs the function of p53 in approximately half of all human cancers.
Zhengding Su (1697299) +5 more
core +1 more source
The p53/Mdm2 Pathway in Hepatocellular Carcinoma: From Molecular Pathogenesis to Targeted Therapies
LiversHepatocellular carcinoma (HCC) is the most common type of liver cancer, and accounts for over 800,000 deaths worldwide, making it a major global health concern.
Keara Kirkness, Derek A. Mann
doaj +1 more source