Results 141 to 150 of about 7,268 (227)

Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition

, 2016
MDM2 and MDMX are oncogenic homologue proteins that regulate the activity and stability of p53, a tumor suppressor protein involved in more than 50% of human cancers.
Nicola Giacchè (1871518), Gabriele Cruciani (475267), Massimo Baroni (651295), Roberto Pellicciari (1717273), Andrea Carotti (1828234), Antonio Macchiarulo (182335)   +5 more
core   +1 more source

Multiple modes of Mdmx regulation affect p53 activation

, 2008
MDMX has emerged as a negative regulator of p53 transcriptional activity following DNA damage, loss of ribosomal integrity, and aberrant mitogenic signaling.
Gilkes, Daniele M., Gilkes, Daniele M
core  

Is MDMX the better target?

Aging, 2018
Kon, Ning, Gu, Wei
openaire   +2 more sources

Mdmx: A p53 activator? [PDF]

Cell Cycle, 2012
openaire   +3 more sources

MDM2/X mediates reduced apoptosis in the plateau zokor: a mechanism of high-altitude adaptation. [PDF]

J Zhejiang Univ Sci B
Zhang M, Li Y, Lin H, Yu T, Xia F, Chatoo M, Li K, Yu H, Nevo E, DU J, Zhao Y, Chen X.   +11 more
europepmc   +1 more source

Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer. [PDF]

Pharmaceuticals (Basel)
Nguyen HTN, Le BHN, Van NTH, Tran TTT, Nguyen MT.   +4 more
europepmc   +1 more source

Computational alanine scanning with GBSA and interaction entropy: a review of methodologies and applications in protein-protein and protein-ligand binding. [PDF]

Chem Sci
Liu X, Xu X, Duan LL, Zhang JZH.
europepmc   +1 more source

RING finger E3 ubiquitin ligases: novel therapeutic opportunities in melanoma. [PDF]

Cell Mol Biol Lett
Zhang JF, Li LT, Yang YY, Zhang SC, Gao C, Zhu X, Xin H, Li XY.   +7 more
europepmc   +1 more source

The Structure, Pathogenesis, and Inhibition of the p53-MDM2 Pathway. [PDF]

Cancers (Basel)
Brown AL, Lian X, Wang Q.
europepmc   +1 more source

Completed clinical trials of p53-targeted therapeutic strategies in cancer: A cross-sectional ClinicalTrials.gov registry analysis. [PDF]

Medicine (Baltimore)
Alorfi NM, Alourfi NM.
europepmc   +1 more source